Clinical trials: Hospital Acquired Condition
Pneumonia Ventilator Associated
Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment
The duration of treatment of community acquired pulmonary infection varies between 5 and 14 days according to the authors (22), or even 3 days with new drugs having long half-life (2).
- Trial name
- NCT01559753
- Testing
- Augmentin, Ceftriaxone, Cefotaxime, netilmycin, tobramycin, compare 8 to15 days of antibiotic treatment
- Volunteers
- 225 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator Associated Pneumonia
Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia
The purpose of this study is to determine if oral mucosal application of chlorhexidine gel will prevent the development of ventilator associated pneumonia in children.
- Trial name
- NCT00597688
- Testing
- Chlorhexidine gel
- Where
- India
- Volunteers
- 86 people
- Sponsor
- All India Institute of Medical Sciences
Ventilator-Associated Pneumonia (VAP), Inha'le'd
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation is as high as 20% -71%, which…
- Trial name
- NCT06819462
- Testing
- Inhaled colistin, Inhaled 0.9% sodium chloride
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Southeast University, China
Ventilator Associated Pneumonia
Diagnostic Stewardship for Ventilator Associated Pneumonia
The goal of this pragmatic cluster-randomized crossover trial is to test if less unnecessary antibiotics are prescribed when the lab reports respiratory culture test results in a specific way for patients who have respiratory…
- Trial name
- NCT05989269
- Testing
- Modified lab reporting
- Where
- 3 sites in United States
- Volunteers
- 161 people
- Sponsor
- University of Maryland, Baltimore
Ventilator Associated Pneumonia
Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care
Increasing emergence of multidrug resistant (MDR) bacteria worldwide is now considered one of the most urgent threats to global health.
- Trial name
- ASPIC (NCT05124977)
- Testing
- Antimicrobial Stewardship, Standard management
- Where
- France
- Volunteers
- 590 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator-Associated Pneumonia
Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates
comparing the effect of oral care with colostrum, chlorohexidine and sodium bicarbonate in prevention of ventilator-associated pneumonia in preterm neonates.
- Trial name
- NCT07482007
- Testing
- Oropharyngeal Care with Colostrum, Chlorhexidine Oral Care, Sodium Bicarbonate oral care
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Hospital-Acquired Infection, Influenza
Nosocomial Influenza Surveillance 2018 - 2022
Hospital-acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Furthermore, it is also associated with a large economic impact for the hospitals.
- Trial name
- NOSOGRIPPE (NCT03413228)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Hospices Civils de Lyon
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between…
- Trial name
- HOMI-LUNG-HAP (NCT06602934)
- Testing
- Blood samples, Oropharyngeal swabs, ECG
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Ventilator Associated Pneumonia ( VAP)
VAP Identification by AI
Ventilator-associated pneumonia (VAP) is the most frequent infection in the intensive care setting. For VAP there is currently no reliable diagnostic criteria.
- Trial name
- AI-VAP (NCT06917521)
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Ventilator-Associated Pneumonia, Mechanical Ventilation
Prevention of Ventilator-Associated Pneumonia by Automatic Control of the Tracheal Tube Cuff Pressure
Background: The aspiration of contaminated secretions pooled above the endotracheal tube cuff secondary to inadvertent falls of cuff pressure is the main pathogenic mechanism of ventilator-associated pneumonia (VAP).
- Trial name
- NCT00364299
- Testing
- Automatic control of tracheal tube cuff pressure
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Clinic of Barcelona
Intubation Complication, Stroke, Ischemic
Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning
Adults who are unconscious or severely ill and need a breathing tube connected to a ventilator are at high risk of developing a lung infection (pneumonia) within the first few days in the intensive care unit.
- Conditions
- Intubation Complication, Stroke, Ischemic, Stroke Hemorrhagic, Head Trauma
- Trial name
- PIRAMIDES (NCT06113939)
- Testing
- airway clearance, subglottic secretion aspiration, Ceftriaxone 2 grams daily
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital San Carlos, Madrid
Ventilator Associated Pneumonia, Aspiration
Ventilator Aspiration With PneuX (PneuX vs Standard Care Feasibility RCT)
This is a single centre, open-label, feasibility randomised controlled trial. The study aims to assess the feasibility of conducting an RCT to compare the PneuX ETT with standard care in hospitalised patients requiring mechanical…
- Conditions
- Ventilator Associated Pneumonia, Aspiration, Infections, Ventilator Lung
- Trial name
- VAP-X (NCT05410106)
- Testing
- PneuX Endotracheal Tube, Standard care (Taperguard, Covidien)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Mechanical Ventilation Complication
Effect of Intermittent Versus Continuous Subglottic Secretion Drainage on Tracheal Mucosa Damages
Endotracheal tubes with subglottic secretion drainage (incorporating a suction port above the cuff) have been shown to reduce the incidence of ventilator-associated pneumonia.
- Trial name
- ASPIRE (NCT01555229)
- Testing
- Intermittent subglottic secretion drainage, Continuous subglottic secretion drainage
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Ventilator Associated Pneumonia
Antibiotic Therapy Practices for Ventilator-Associated Pneumonia (PETUNIA)
The French Society of Intensive Care conducts a comprehensive assessment of current antibiotic therapy practices in critically ill patients suspected of Ventilator-Associated Pneumonia (VAP).
- Trial name
- PETUNIA (NCT06243094)
- Testing
- Antibiotic
- Where
- France
- Volunteers
- 1,060 people
- Sponsor
- French Society for Intensive Care
Hospital Acquired Infection
The Impact of Bedside Wipes in Multi-patient Rooms: a Prospective, Crossover Trial Evaluating Infections and Survival
Multidrug resistant organisms (MDRO) are prevalent in hospitals and are associated with hospital-acquired infections (HAI). High-touch surfaces serve as reservoirs and fomites for MDRO transmission.
- Trial name
- NCT05522725
- Testing
- Single-use wipes installed at the bedside
- Where
- Israel
- Volunteers
- 7,725 people
- Sponsor
- Assaf-Harofeh Medical Center
Community-associated Infections, Health-care Acquired Infections
Optimal Antibiotic Treatment of Moderate to Severe Bacterial Infections
Severe bacterial infections are associated with mortality of about 30%. Patients with moderate to severe bacterial infections given early and appropriate empirical antibiotic treatment are at a lesser risk for a fatal outcome…
- Conditions
- Community-associated Infections, Health-care Acquired Infections, Nosocomial Infections
- Trial name
- CDSS (NCT01338116)
- Testing
- antibiotic treatment of by TREAT/PCR
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Rabin Medical Center
Microbial Colonization, COVID-19 Respiratory Infection
Impact of Teeth Brushing in Ventilated COVID-19 Patients.
The aims of this study were: 1. Observation of dynamics in oral microbiota and its association with the incidence of HAIs and VAP in mechanically ventilated COVID-19 patients in an ICU setting 2.
- Conditions
- Microbial Colonization, COVID-19 Respiratory Infection, Dysbiosis, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT05575050
- Testing
- Oral Procedure
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- University Hospital in Krakow