Clinical trials: Histamine, open to volunteers
Irritable Bowel Syndrome (IBS)
Personalized Probiotic Treatments for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is characterized by stomach pain and altered bowel habits. It affects about 5 million people in Canada. Doctors don't fully understand what causes IBS, so treatments often don't work well.
- Trial name
- NCT07872514
- Testing
- Probiotic containing B longum, Probiotic Lactobacillus
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Lymphoma
PPI Versus Histamine Antagnists as Adjuvant to Chemotherapy
The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump I nhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma.
- Trial name
- NCT03647072
- Testing
- CHOP, CHOP Plus Lanzoprazole, CHOP Plus Famotidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sherief Abd-Elsalam
Histamine, Cowhage
Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: To investigate similarity and differences between itch and pain by comparing the effect of sleep…
- Conditions
- Histamine, Cowhage, Sleep Deprivation
- Trial name
- NCT06081998
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Allergic Reactions, Allergic Skin Reaction
Determination of Blomia Tropicalis Allergen Extract in Prick Test Units
The primary objective is to assess the concentration of Blomia tropicalis allergenic extract that induces a wheal of size equivalent to that produced by a 10 mg/mL histamine dihydrochloride solution, in order to be used as…
- Trial name
- NCT07195929
- Testing
- Allergenic Extract
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Inmunotek S.L.
Histamine
The Role of Histamine in Muscle Protein Synthesis Following Resistance Training
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten…
- Trial name
- NCT06152497
- Testing
- H1 blockade: Telfast: 180mg Fexofenadine, Resistance training
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Ghent
Pancreatic Cancer, Surgery
Histamine Dihydrochloride and Interleukin-2 in Primary Resectable Pancreatic Cancer
A key aspect of the trial is that functions of anti-neoplastic T cells and natural killer (NK) cells, may be inhibited by immunosuppressive signals from myeloid cells, in particular reactive oxygen species (ROS) produced by…
- Conditions
- Pancreatic Cancer, Surgery, Metastasis, Immunosuppression
- Trial name
- PANCEP-1 (NCT05810792)
- Testing
- Histamine Dihydrochloride (HDC), Interleukin-2 (IL-2)
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Histamine, Exercise
Histamines and Central Hemodynamics
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with…
- Trial name
- NCT07285031
- Testing
- Diphenhydramine hydrochloride, Exercise Bout
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Histamine, Cowhage
Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals
This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies…
- Trial name
- NCT06340438
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Urticaria Chronic
Mediterranean and Low-Histamine Diets for Pediatric Chronic Spontaneous Urticaria
Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease that can substantially impair quality of life in children and adolescents.
- Trial name
- NCT07765979
- Testing
- Low-Histamine Diet, Mediterranean Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Saglik Bilimleri Universitesi
Histamine, Cowhage
Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)
In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of…
- Trial name
- NCT06328530
- Testing
- Cowhage, Histamine
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Chronic Spontaneous Urticaria (CSU), Chronic Idiopathic Urticaria
A Study to Assess the Efficacy and Safety of THB335 in Adults With Chronic Spontaneous Urticaria (CSU)
THB335-201 is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group, multicenter study in adults with CSU who remain symptomatic despite standard-of-care treatment.
- Trial name
- NCT07766499
- Testing
- THB335 Lower Dose, THB335 Higher Dose
- Where
- 15 sites in United States
- Volunteers
- 81 people
- Sponsor
- Calixis Inc.
Allergic Reaction, Allergic Skin Reaction
Quercus Ilex and Quercus Robur Allergen Extracts Standardisation
The objective of this study is to determine the biological activity of Quercus illex and Quercus robur allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP).
- Conditions
- Allergic Reaction, Allergic Skin Reaction, Allergy Pollen
- Trial name
- NCT05532566
- Testing
- Allergenic extract
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Inmunotek S.L.
Rheumatoid Arthritis
Effect of Some Drugs on Rheumatoid Arithritis Activity
Effect of Some Drugs on Rheumatoid Arithritis Activity.
- Trial name
- NCT03770923
- Testing
- Rupatadine, Montelukast
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Sherief Abd-Elsalam
Breast Cancer
A Trial of Camrelizumab Plus Nab-paclitaxel and Levocetirizine in Metastatic or Recurrent TNBC
This is a phase II, explorative, open-labeled, multi-centered, double-arm, investigator-initiated clinical trial of Camrelizumab (an anti-PD-1 antibody) in combination with Nab-paclitaxel (a chemotherapeutic agent against breast…
- Trial name
- NCT06632405
- Testing
- Camrelizumab, Nab paclitaxel, Levocetirizine Hydrochloride
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Pediatric Chronic Spontaneous Urticaria
Pseudoallergen-Free and Low-Histamine Diet in Adolescents With Chronic Spontaneous Urticaria
The goal of this clinical trial is to learn whether a histamine- and pseudoallergen-restricted diet can help reduce symptoms in people with chronic urticaria.
- Trial name
- PAF-LH-CSU (NCT07632040)
- Testing
- Intervention Name: Low-histamine and pseudoallergen-free diet, General healthy eating advice
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University
GI Health
Radicle GI Health™ RFY: A Study Assessing the Impact of DAO Supplementation on Gastrointestinal and Other Histamine Intolerance Symptoms
Radicle GI Health™ RFY: A Randomized, Double-Blind, Placebo-Controlled Study Assessing the Impact of DAO Supplementation on Gastrointestinal and other Histamine Intolerance Symptoms.
- Trial name
- NCT07835776
- Testing
- Active GI Health Product 1
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University