Clinical trials: Histamine
Histamine, Cowhage
Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals
This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies…
- Trial name
- NCT06340438
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus
Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin Prick
To determine the effective dose and the time course, the dermal blood flow response to histamine will be evaluated at different doses (5 µg, 15 µg and 50 µg).
- Trial name
- NCT04399213
- Testing
- 50 µg Histamine, 15 µg Histamine, 5 µg Histamine
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rhinitis, Allergic, Seasonal
Investigation Of a New Oral Anti-Histamine in Healthy Male Subjects
This study is designed to assess the safety and tolerability of single, escalating oral doses and repeat oral doses (7 days, once daily) of GSK835726 in healthy male subjects
- Trial name
- NCT00605852
- Testing
- GSK835726
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Itch
Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% As a New Surrogate Model of Itch
The aim of this research project is to design a new model of human itch by application of Zyclara cream. Further, the aim is to characterize the model and to verify if the mechanism of action of imiquimod follows the…
- Trial name
- NCT03943407
- Testing
- Zyclara 3.75 % Topical Cream, Prudoxin, Histamine
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aalborg University
GI Health
Radicle GI Health™ RFY: A Study Assessing the Impact of DAO Supplementation on Gastrointestinal and Other Histamine Intolerance Symptoms
Radicle GI Health™ RFY: A Randomized, Double-Blind, Placebo-Controlled Study Assessing the Impact of DAO Supplementation on Gastrointestinal and other Histamine Intolerance Symptoms.
- Trial name
- NCT07835776
- Testing
- Active GI Health Product 1
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Persons With Mild to Moderate Knee Osteoarthritis
Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis
Study wishes to determine if the use of injectable bee venom is a safe and effective treatment for persons with mild to moderate knee Osteoarthritis and would result in decreased report of pain and discomfort, increased function…
- Trial name
- NCT00253942
- Testing
- Injecting bee venom as a treatment for OA
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rheumatology Therapeutics Medical Center
Lymphedema
Validation of the MoistureMeterD in Local Edema by Histamine
In lymphedema there is increase in water content of the tissue. We studied a device (MoistureMeterD) which is suitable to detect water contact in the tissue.
- Trial name
- NCT01833156
- Testing
- MoistureMeterD
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Nij Smellinghe Hosptial
Histamine, Cowhage
Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)
In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of…
- Trial name
- NCT06328530
- Testing
- Cowhage, Histamine
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Asthma
XC8 Safety, Tolerability and Pharmacokinetics in Healthy Volunteers
A double-blind, randomized, placebo-controlled, Phase I clinical study of the safety and tolerability of increasing doses of XC8 after single and repeated oral administration in healthy volunteers.
- Trial name
- NCT03441815
- Testing
- XC8
- Where
- Russia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PHARMENTERPRISES LLC
Exercise, Histamine
Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on…
- Trial name
- NCT05131555
- Testing
- H1 blockade: H1 receptor antagonist + exercise training, H2 Blockade: H2 receptor antagonist + exercise training
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Ghent
Exercise Training, Physical Activity
Histamine H1/H2 Receptors and Training Adaptations
Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response.
- Trial name
- NCT04450134
- Testing
- Lactose, Fexofenadine Hydrochloride, Famotidine
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Ghent
Migraine, Sinusitis
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers
The primary objective of this study is to evaluate histamine, CGRP and VIP levels in saliva as biological markers for activation of trigeminal and parasympathetic nerve fibers in various clinical presentations of primary…
- Trial name
- NCT00208065
- Testing
- almotriptan or pseudoephedrine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinvest
Cognitive Disorders
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects
The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of SUVN-G3031 in healthy male subjects following single or multiple ascending doses.
- Trial name
- NCT02342041
- Testing
- SUVN-G3031
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Pruritus
Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
In order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the…
- Trial name
- NCT04399525
- Testing
- Desloratadine Single Dose, Levocetirizine Single Dose, Desloratadine Fourfold Dose
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Subjects
A Human Trial to Evaluate the Effects of Chungkookjang on Histamine-induced Wheal Size in Healthy Subjects
The investigators investigate the effect of Chungkookjang on histamine-induced skin reaction in a double-blind, randomized, placebo-controlled, human trial
- Trial name
- NCT01402141
- Testing
- Chungkookjang
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Wounds and Injuries
Alpha-Bisabolol Gel With Antihistamine Action
It will be developed and evaluated the antihistamine potential of a gel containing alpha-bisabolol. Method: Interventional and cross-sectional study, with convenience sampling, conducted with 20 volunteers.
- Trial name
- NCT05022108
- Testing
- Alpha bisabolol gel
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Migraine
A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults
PF-05180999 is a phosphodiesterase-2 inhibitor that is hypothesized to be able to reduce vascular permeability. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and effects on histamine-induced…
- Trial name
- NCT01981499
- Testing
- PF-05180999, 120 mg MR PF-05180999, 360 mg MR PF-05180999
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pruritus
Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch
The purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage.
- Trial name
- NCT02769910
- Testing
- Capsaicin 24 Hours, Capsaicin 1 Hour, Qutenza Demo Patch
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hjalte Holm Andersen
Migraine
Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin
The involvement of calcitonin gene-related peptide (CGRP) in the cinnamaldehyde-induced dermal blood flow increase and in the mechanism of action of triptans will be investigated.
- Trial name
- NCT05654298
- Testing
- Sumatriptan, Ubrogepant
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
A Comparison of Scalp Blood Flow and Hair Shaft In Premenopausal Women Versus Postmenopausal Women
The purpose of this study is to compare the differences in various chemical and biologic parameters of scalp and and hair parameters between young and old Caucasian females.
- Trial name
- NCT01831180
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wake Forest University