Clinical trials: High-risk Pregnancy
Hypertension, Cardiovascular Disease
Population Based Strategies for Effective Control of High Blood Pressure in Pakistan
Studies have established that high blood pressure (BP) is the most common risk factor for cardiovascular disease (CVD). Despite a heavy burden of hypertension (33% of all persons aged 45 years and over), there are no reliable…
- Conditions
- Hypertension, Cardiovascular Disease, Obesity, Diabetes
- Trial name
- NCT00327574
- Testing
- Home heath education +/_ GP training
- Where
- Pakistan
- Sponsor
- Aga Khan University
Hydatidiform Mole
RCT on the Efficacy of Methotrexate for the Prevention of GTD
A randomized, controlled trial to evaluate the efficacy of methotrexate for the prevention of postmolar gestational trophoblastic disease among patients with high-risk hydatidiform mole.
- Trial name
- NCT01984099
- Testing
- Methotrexate, Vitamin B Complex
- Where
- Philippines
- Volunteers
- 99 people
- Sponsor
- University of the Philippines
Ovarian Cancer
Short-course HIPEC in Advanced Epithelial Ovarian Cancer
This is an open-label, multicenter, single-arm, feasibility phase 2 trial on safety and efficacy of short-course regimen of intra-operative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at the time of fast-track interval…
- Trial name
- NCT02249013
- Testing
- Cytoreductive Surgery (CRS), Hyperthermic Intraperitoneal Chemotherapy (HIPEC), Neoadjuvant Chemotherapy (NACT)
- Volunteers
- 15 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Neoplasms, Endometrial
A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Recurrent or Advanced Endometrial Cancer (EC)
The goal of this study is to evaluate the safety profile of dostarlimab in Indian adults with recurrent or advanced endometrial cancer.
- Trial name
- NCT06897527
- Testing
- Dostarlimab
- Volunteers
- 100 people
- Sponsor
- GlaxoSmithKline
Cervical Persistent High Risk HPV Infection, Cervical Intraepithelial Neoplasia
Aminolaevulinic Acid Photodynamic Therapy of Cervical Persistent HPV Infection and Cervical Neoplasia
The study will examine the effect of aminolaevulinic acid (ALA) photodynamic therapy (PDT) of cervical precancerous lesions in women.
- Trial name
- NCT02304770
- Testing
- Aminolaevulinic acid photodynamic therapy
- Where
- 4 sites in China
- Volunteers
- 73 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Cervical Cancer, Cervical Intraepithelial Neoplasia
HPV-cytology Testing Versus Cytology Testing for the Detection of High Grade CIN
To compare the effects of conventional cytology testing with concommitant HPV-cytology testing for the detection of high grade cervical lesions in primary cervical cancer screening in Hong Kong Hypotheses: 1.
- Trial name
- COCY (NCT01058460)
- Testing
- HPV-cytology co-testing
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
NMIBC
Immediate Chemotherapy Following Resection for High-Risk Non-Muscle-Invasive Bladder Cancer
Residual tumors after transurethral resection of bladder tumors (TURBT) range from 17-70%, and floating tumor cells from traditional segmental resection may lead to recurrence if they re-implant in the bladder wall.
- Trial name
- HIGCrecur (NCT06889623)
- Testing
- Immediate postoperative chemotherapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Changhai Hospital
Bladder Cancer, Urinary Bladder Neoplasms
A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)
Researchers are looking for new ways to treat high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder and has not spread to the bladder muscle or outside of the…
- Trial name
- NCT07222488
- Testing
- MK-3120
- Where
- 17 sites in United States, Austria and 10 more
- Volunteers
- 45 people
- Sponsor
- Merck Sharp & Dohme LLC
Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
Ruxolitinib Phosphate, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase I/II trial studies the side effects and the best dose of ruxolitinib phosphate when given together with paclitaxel and carboplatin and to see how well they work in treating patients with stage III-IV epithelial…
- Conditions
- Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, FIGO Stage III Ovarian Cancer 2014
- Trial name
- NCT02713386
- Testing
- Carboplatin, Paclitaxel, Ruxolitinib Phosphate
- Where
- 110 sites in United States
- Volunteers
- 147 people
- Sponsor
- NRG Oncology
Gestational Diabetes, Gestational Hypertension
The Effect of High Dose Folic Acid Versus Placebo on the Rate of Gestational Diabetes or Gestational Hypertension in Pregnant Women
The purpose of this study is to determine if higher-than usual doses of daily folic acid has an effect on the rate of gestational diabetes mellitus (GDM) or gestational hypertension in pregnant women while determining status of…
- Trial name
- NCT01302756
- Testing
- Folic Acid
- Sponsor
- Mike O'Callaghan Military Hospital
Renal Stones, Calculus
Comparison of ESWL and Mini-PCNL for High-Density Renal Stones in Children
Pediatric nephrolithiasis is an increasing health problem, with rising prevalence particularly in certain geographic regions. Management options for pediatric renal stones include extracorporeal shockwave lithotripsy (SWL)…
- Conditions
- Renal Stones, Calculus, Pediatric, Endoscopy
- Trial name
- NCT07360041
- Testing
- Miniaturized Percutaneous Nephrolithotomy (mini-PNL), Shock Wave Lithotripsy (SWL)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Pregnancy Complicated by Low Implantation
Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial
Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept.
- Trial name
- ILRIFRM (NCT01679561)
- Testing
- intralipid
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Cervical Cancers
Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).
This is a prospective non-randomized clinical trial to evaluate the feasibility of 3 fraction versus a standard 4 fraction high dose rate brachytherapy regimen in patients with locally advanced cervical cancer.
- Trial name
- NCT07022470
- Testing
- 3-Fraction HDR Brachytherapy, 4-Fraction HDR Brachytherapy
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Preterm Birth
Effect of Probiotics on the Preterm Delivery Rate in Pregnant Women at High Risk for Preterm Birth
Preterm birth (PB) continues to be the main cause of perinatal morbidity and mortality, with emotional and economic consequences.
- Trial name
- PROPEV (NCT03689166)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Chronic Kidney Failure
Efficacy and Safety Study of Magnesium Iron Hydroxycarbonate for the Reduction of High Blood Phosphate in Hemodialysis Patients
Magnesium iron hydroxycarbonate is a phosphate binder that absorbs phosphate from food, reducing the amount that the body can absorb.
- Trial name
- NCT00317694
- Testing
- Fermagate
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 111 people
- Sponsor
- Ineos Healthcare Limited
Ovarian Cancer, Fallopian Tube Cancer
Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer
This is a phase II study in patients with recurrent platinum resistant or refractory C5 high-grade serous, endometrioid or undifferentiated ovarian, primary peritoneal or fallopian tube cancer.
- Trial name
- NCT03188159
- Testing
- Vinorelbine
- Where
- 2 sites in Australia, Singapore
- Volunteers
- 36 people
- Sponsor
- National University Hospital, Singapore
Atherosclerosis, Chronic Kidney Disease
Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy
The aim of the study is to value, in patients with chronic kidney disease and hypertension, whether medical therapy plus interventional renal artery revascularization is superior to medical therapy alone for the treatment of…
- Conditions
- Atherosclerosis, Chronic Kidney Disease, Hypertension, Renovascular, Ischemic Nephropathy
- Trial name
- NITER (NCT01023373)
- Testing
- Medical treatment, PTRS, renal artery stent
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Non Muscle Invasive Bladder Cancer
A Study Comparing the Necessity of a Second Transurethral Resection in High-Risk Non-Muscle-Invasive Bladder Cancer Patients With Negative Results From Post-Initial Resection Urine Genome-Wide Low-Depth Sequencing
This study is a prospective, randomized, multicenter clinical trial aiming to enroll 428 patients with non-muscle-invasive bladder cancer (NMIBC) from the Department of Urology at Jiangsu Provincial People's Hospital and its…
- Trial name
- NCT07036731
- Testing
- Urine biomarker -Guided without reTURBT
- Where
- China
- Volunteers
- 428 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
PreTerm Birth, PreTerm Neonate
Trial of Immediate vs. Delayed Cord Clamping in the Preterm Neonate
To determine the short and long term effects of placental transfusion at birth by milking and delayed cord clamping of the umbilical cord in neonates born between 24 weeks 0 days and 34 weeks 0 days weeks' gestation.
- Trial name
- NCT00579839
- Testing
- Delayed Cord Clamping, Immediate Cord Clamping
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma