Clinical trials: High-risk Cardiac Patients
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Myocardial Infarction
Feasibility of High Frequency QRS Analysis in Patients With Acute Myocardial Infarction
The primary objective of this study is to characterize the morphological patterns of high frequency QRS components (HFQRS) in patients with acute myocardial infarction (AMI), including STEMI and NSTEMI, compared to patients…
- Trial name
- NCT01150825
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- BSP Biological Signal Processing Ltd.
Chronic Heart Failure, High Blood B-type (or Brain) Natriuretic Peptide (BNP) Level
Study to Demonstrate the Non-inferiority of Olmesartan Medoxomil Versus Candesartan Cilexetil in Reducing Blood B-type (or Brain) Natriuretic Peptide Levels at Week 24
This study will compare olmesartan medoxomil to candesartan cilexetil in reducing BNP, a prognostic biomarker of heart failure, at week 24
- Trial name
- OLMEBNP (NCT00679484)
- Where
- 11 sites in France, Germany and 1 more
- Volunteers
- 400 people
- Sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Atherosclerotic Cardiovascular Disease
A Research Study Looking at How NNC0385-0434 Tablets Work to Lower Blood Cholesterol in People With Heart Disease or a High Risk of Heart Disease
This study looks at how well a new medicine, NNC0385-0434, works to lower blood cholesterol levels. Participants will either get NNC0385-0434 as a tablet (a potential new medicine), or placebo as a tablet (a dummy medicine that…
- Trial name
- NCT04992065
- Testing
- NNC0385-0434 A 15 mg, NNC0385-0434 A 40 mg, NNC0385-0434 A 100 mg
- Where
- 44 sites in United States, Belgium and 5 more
- Volunteers
- 267 people
- Sponsor
- Novo Nordisk A/S
Hyperlipemia, Coronary Heart Disease
Effect of Rosuvastatin Therapy on HDL2 Level
In many large trials, reducing low density lipoprotein (LDL) levels with rosuvastatin decreased the incidence of major cardiovascular events，but little attention to the effects of rosuvastatin on HDL level，especially on HDL…
- Trial name
- NCT02593487
- Testing
- Rosuvastatin 10mg/d group, Rosuvastatin 20mg/d group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
ST-elevation Myocardial Infarction
Evaluation of Myocardial Reperfusion After Primary PCI in Patients With High Platelet Reactivity Treated by Cangrelor or Not
This study aims to evaluate the impact on myocardial reperfusion and residual thrombotic burden of adding Cangrelor -a potent and immediate P2Y12 inhibitor- to ticagrelor in primary PCI patients with high on ticagrelor platelet…
- Trial name
- ERMIT (NCT04927949)
- Testing
- cangrelor perfusion during PCI, standard PCI
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Caen
Heart Failure, Congestive
Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).
The purpose of this study is to evaluate the safety of KW-3902IV compared to placebo and to determine the diuretic effect of KW-3902IV compared to placebo in patients hospitalized with volume overload due to CHF who are…
- Trial name
- NCT00159627
- Testing
- KW-3902IV
- Where
- 10 sites in United States
- Volunteers
- 52 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Coronary Stenosis
EluNIR Ridaforolimus Eluting Coronary Stent System in Patients at High Bleeding Risk (HBR)- EluNIR HBR Study
The study will enroll approximately 316 subjects with a wide spectrum of PCI indications (stable angina as well as ACS), who are considered to be at high risk of bleeding.
- Trial name
- NCT03877848
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- Israel
- Volunteers
- 319 people
- Sponsor
- Medinol Ltd.
Major Coronary Event, Cerebrovascular Accident
CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events
A study to assess the efficacy of once daily atorvastatin 10 mg versus placebo on cardiovascular endpoints in patients with non-insulin-dependent diabetes mellitus (NIDDM) who have a history of either hypertension, retinopathy…
- Conditions
- Major Coronary Event, Cerebrovascular Accident, Coronary Artery Bypass Graft, Angina, Unstable
- Trial name
- CARDS (NCT00327418)
- Testing
- Atorvastatin
- Where
- 135 sites in United Kingdom
- Volunteers
- 2,800 people
- Sponsor
- Pfizer
Coronary Artery Disease
Feasibility of High-Intensity Interval Nordic Walking in Patients With Coronary Artery Disease
Coronary revascularization, such as heart bypass surgery (CABG) and percutaneous coronary intervention (PCI [inserting a stent to open up blood vessels]) improve survival for people with coronary artery disease.
- Trial name
- HIIT-NoW (NCT05434117)
- Testing
- High-intensity interval Nordic walking, Standard cardiovascular rehabilitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Coronary Syndrome, Chest Pain
Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin
The broad, long-term objective is to improve outcomes by optimizing healthcare delivery processes for patients with detectable to elevated serum troponin.
- Trial name
- CMR-IMPACT (NCT01931852)
- Testing
- Cardiac MRI, ACC/AHA Guideline adherent care
- Where
- 4 sites in United States
- Volunteers
- 312 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Artery Disease
The Study to Evaluate the Safety and Efficacy of the Onyx Family
Observation of the safety and efficacy of 1-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention using Onyx family stents in elderly patients aged 75 years or older
- Trial name
- NCT06577896
- Testing
- Onyx family
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Pusan National University Yangsan Hospital
Chronic Kidney Disease, Stable Angina
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease
Impaired renal function is associated with reduced responsiveness to clopidogrel. There are no studies which have shown a means by which to overcome platelet hyporesponsiveness in patients with chronic kidney disease (CKD).
- Trial name
- CKD (NCT01328470)
- Testing
- Clopidogrel, cilostazol
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Kyunghee University Medical Center
Cardiovascular Disease, Coronary Heart Disease, Dyslipidemia, Peripheral Arterial Disease (PAD)
A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease…
- Trial name
- NCT01516541
- Testing
- Background care, dalcetrapib
- Where
- 241 sites in United States, Australia and 11 more
- Volunteers
- 2,220 people
- Sponsor
- Hoffmann-La Roche
Coronary Artery Disease
High Definition CT Coronary Angiography Accuracy Trial
CT technology is evolving at a rapid pace, with introduction of multidetector row CT scanners (MDCT) and electrocardiographic (ECG) gating resulting in increasing numbers of heart scans CTCA (CT Coronary Angiography).
- Trial name
- NCT01946737
- Testing
- HD-CTCA with Adaptive statistical iterative reconstruction (ASIR), Active Comparator: Invasive coronary angiography (ICA)
- Where
- United Kingdom
- Volunteers
- 302 people
- Sponsor
- University Hospital Plymouth NHS Trust
Myocardial Infarction, Heart Failure
Effect of Exercise Training on Left Ventricular Function in Patients Post Myocardial Infarction
Patients who have suffered a heart attack are at risk of developing worsening heart function and heart failure. Exercise training has a beneficial effect on heart function and prevents heart failure.
- Conditions
- Myocardial Infarction, Heart Failure, Coronary Artery Disease
- Trial name
- EXIT-V (NCT02048696)
- Testing
- Secondary prevention and cardiac rehabilitation clinic
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute