Clinical trials: High Risk Pregnancy
Cardiac Surgery
Evaluation of Renal Function in Subjects Who Had Undergone Cardiac Surgery
To evaluate the differences between serum cystatin C based estimated glomerular filtration rate (eGFRcys), serum creatinine based eGFR (eGFRcreat) and measured glomerular filtration rate (mGFR) in subjects at high risk for acute…
- Trial name
- NCT04654221
- Testing
- mGFR by iohexol clearance
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- Quark Pharmaceuticals
Unspecified Adult Solid Tumor, Protocol Specific
Phase 1/2 Clinical Trial of CP-506 (HAP) in Monotherapy or With Carboplatin or ICI
A modular, first time in human, open label, multiple dose, accelerated escalation with cohort expansion study of the safety and pharmacokinetics of intravenous infusion of CP-506, a tumor agnostic Hypoxia Activated Prodrug in…
- Trial name
- NCT04954599
- Testing
- CP-506, Carboplatin, Immune checkpoint inhibitor
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 126 people
- Sponsor
- Maastricht University Medical Center
Recurrent Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8
Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy
This phase III trial compares the effect of adding gemcitabine to intravesical Bacillus Calmette Guerin (BCG) versus intravesical BCG alone in patients with non-muscle invasive bladder cancer that has come back after a period of…
- Conditions
- Recurrent Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8, Stage I Bladder Cancer AJCC v8
- Trial name
- GAIN-BCG (NCT07000084)
- Testing
- BCG Solution, Biopsy of Bladder, Cystoscopy
- Where
- 60 sites in United States
- Volunteers
- 330 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cervical Cancer, Cervical Cancer Screening
Human Papillomavirus Self-sampling for Enhancing Cervical Screening During the War in Ukraine
In 2020, a cervical screening center was established in Zaporizhzhia (Ukraine), initiating a pilot project to evaluate the prevalence of HPV among women in Eastern Ukraine.
- Conditions
- Cervical Cancer, Cervical Cancer Screening, Human Papillomavirus (HPV) Infection, Cervical Intraepithelial Neoplasia
- Trial name
- NCT07275333
- Testing
- HPV Self-Sampling Kit
- Where
- Ukraine
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Gestational Diabetes Mellitus in Pregnancy, Pregnancy, High Risk
Early Detection of Gestational Diabetes Mellitus in Pregnancy
The purpose of this study is to develop an implementation protocol and test the feasibility and acceptability of a first trimester screening protocol for the early detection of gestational diabetes mellitus (GDM).
- Trial name
- NCT05388643
- Testing
- Enhanced First Trimester GDM Screening, Routine Gestational Diabetes Screening
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Massachusetts, Worcester
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Acute Kidney Injury
Early Prediction of Acute Kidney Injury in High Risk Patients After Non-cardiac Surgery
Acute kidney injury (AKI) is a common complication after non-cardiac surgery with adverse short and long term morbidity and mortality.
- Trial name
- NCT03880110
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University First Hospital
Telemedicine, Digital Health
Development of an International Remote Digital Care System for Accessible, Inclusive and Sustainable Pregnancy Care
Pregnancy care is under increasing pressure due to a rising number of women needing medical care, a shortage of obstetric healthcare professionals, and growing healthcare costs.
- Conditions
- Telemedicine, Digital Health, Pregnancy Complications
- Trial name
- PregnaDigit EU (NCT07191236)
- Where
- 4 sites in Netherlands, Spain and 1 more
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
High Risk Pregnancy
Guided Imagery on the Perceived Stress Level in High-Risk Pregnancies
This research was conducted to identify the effect of the practice of Guided Imagery on the perceived stress level in high-risk pregnancies.
- Trial name
- NCT05021289
- Testing
- guided imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Nursel Alp Dal
Acute Kidney Failure Stage 3, Continuous Renal Replacement Therapy (CRRT)
Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
During critical illness, patients experience a hypercatabolic state. This hypercatabolic state causes muscle wasting in patients, resulting in intensive care unit acquired weakness (ICU-AW).
- Trial name
- PROTEIN-CRRT (NCT07596043)
- Testing
- High protein group, Standard protein group
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Chulalongkorn University
Preeclampsia
The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia
This study is prospective, single arm group ,open label, and multicenter trial (with two parallel-group [Hydroxychloroquine 200mg with Aspirin 100mg or Aspirin 100mg])
- Trial name
- HUGS (NCT05287321)
- Testing
- Hydroxychloroquine
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Yoo-min Kim
Pelvic Floor Disorders
Botox for Chronic Pelvic Pain
The purpose of this research study is to find out if precise, targeted injection of botulinum neurotoxin (commonly known as Botox) provides better relief of pelvic floor hypertonicity and pain than the standard method being used.
- Trial name
- NCT06796985
- Testing
- Botulinum neurotoxin, High Density Surface Electromyographic, precision botulinum neurotoxin injection guidance medical device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Cesarean Section
Antepartum Cardiotocography With and Without Computer Analysis in High Risk Pregnancies
Electronic fetal hear rate monitoring (EFM), or cardiotocography (CTG), records changes in fetal heart rate and their temporal relationship to uterine contraction.
- Trial name
- NCT03862976
- Testing
- computerized cardiotocography
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Federico II University
Precancerous Lesions, Conization
A Cohort Study for the Following up of Conization
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital.
- Conditions
- Precancerous Lesions, Conization, High Grade Intraepithelial Neoplasia, Uterine Cervical Cancer
- Trial name
- NCT03961178
- Testing
- High-risk HPV, TCT
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Melanoma, Non-small Cell Lung Cancer
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
- Conditions
- Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma (Skin), Renal Cell Carcinoma
- Trial name
- NCT07115043
- Testing
- AZD6750, rilvegostomig
- Where
- 13 sites in United States, Australia and 2 more
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Smoking Cessation
Interventions of Smoking Cessation During Pregnancy
The aim of this clinical trial is to test whether offering pregnant smokers a high intensity intervention for smoking cessation increases the rate of smoking cessation at the third trimester of pregnancy, compared to low…
- Trial name
- NCT01210118
- Testing
- Low intensity intervention, Higher intensity intervention
- Where
- 2 sites in Greece
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hellenic Anticancer Society
Chronic Kidney Disease, Diabetes
Improving Chronic Disease Management With Pieces
ICD-Pieces (Parkland Intelligent e-Coordination and Evaluation System) trial is a National Institutes of Health (NIH) Healthcare Systems(HCS) Collaboratory demonstration project to improve management of patients with a triad of…
- Conditions
- Chronic Kidney Disease, Diabetes, Hypertension, High BP
- Trial name
- ICD-Pieces (NCT02587936)
- Testing
- Collaborative Model of Primary care and Subspecialty care
- Where
- 4 sites in United States
- Volunteers
- 18,268 people
- Sponsor
- University of Texas Southwestern Medical Center
Preeclampsia, Neutrophil
Aspirin and Neutrophils in Preeclampsia
The exact mechanisms by which aspirin prevents the development of preeclampsia in high-risk patients are currently not fully known.
- Conditions
- Preeclampsia, Neutrophil, Immunology, Pregnancy
- Trial name
- NCT04974892
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Queen Mary University of London
Ovarian Cancer, High Grade Ovarian Serous
Using Advanced Imaging Studies to Develop a Profile of High-grade Serous Ovarian Cancer
The researchers are doing this study to find out whether the researchers can combine information provided by PET/MRI scans with information from tests on blood and tissue samples to develop a very detailed description (profile)…
- Trial name
- NCT04454450
- Testing
- PET/MRI, Contrast enhanced CT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
High Risk Infant, Neurodevelopmental Disorder (Diagnosis)
SAFE Early Intervention for At-Risk Infants
This randomized controlled study aims to investigate the effects of the SAFE early intervention approach on upper extremity function, fine motor skills, and developmental outcomes in high-risk infants aged 3-12 months.
- Conditions
- High Risk Infant, Neurodevelopmental Disorder (Diagnosis), Preterm
- Trial name
- SAFE-EFFECT (NCT07596147)
- Testing
- SAFE Early Intervention Program, NDT TREATMENT
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Gazi University
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