Clinical trials: High Cholesterol
Hypercholesterolemia
PMMHRI-Pitavastatin Registry
The PMMHRI-Pitavastatin Registry is a non-interventional, single-center registry conducted at the Polish Mother's Memorial Hospital Research Institute (PMMHRI).
- Trial name
- NCT06858982
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Hypercholesterolemia
Safety and Efficacy of Propionate for Reduction of LDL Cholesterol
The objective of the trial is to evaluate a potential impact of food supplements with the short chain fatty acid propionate on blood LDL cholesterol level.
- Trial name
- PROPER-LDL (NCT03590496)
- Testing
- Calcium-Propionate 500mg
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Charite University, Berlin, Germany
Myalgia, Hypercholesterolemia
Study of the Safety and Tolerability Associated With PPD10558 Versus Atorvastatin in Patients Previously Intolerant to Statins Due to Statin-associated Myalgia (SAM)
The purpose of this study is to assess the incidence of statin-associated myalgia (SAM) with treatment with PPD10558 versus atorvastatin in patients previously intolerant to statins.
- Conditions
- Myalgia, Hypercholesterolemia, Hyperlipidemia
- Trial name
- NCT01279590
- Testing
- PPD10558, Atorvastatin
- Where
- 67 sites in United States
- Volunteers
- 282 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Hypercholesterolemia, Cardiovascular Diseases
Trial to Evaluate Efficacy and Safety of LIB003, Evolocumab and Alirocumab in High-risk CVD Patients
Comparison of LDL-C reductions at Week 12 of monthly (Q4W[≤ 31 days]) dosing of LIB003 300 mg administered subcutaneously (SC) to Q4W dosing of evolocumab (Repatha) 420 mg and alirocumab (Praluent) 300 mg in patients with CVD or…
- Trial name
- LIBerate-H2H (NCT04790513)
- Testing
- lerodalcibep, evolocumab, alirocumab
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- LIB Therapeutics LLC
LDL Cholesterol, Triglycerides
Safety and Efficacy of a Natural Health Product in Reducing Cholesterol and Triglyceride Levels.
The purpose of this study is to assess the safety and efficacy of a natural health product among participants with elevated LDL cholesterol and triglyceride levels.
- Trial name
- NCT01028274
- Testing
- Investigational Product 1, Investigational Product 2
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Nordic Pharma, USA
Hypercholesterolaemia
The Effect of a Red Rice and Olive Extract Nutrition Supplement on Cholesterol Levels in Patients With Metabolic Syndrome
This randomised controlled trial studies the effect of a commercially available nutritional supplement on cholesterol levels in people with metabolic syndrome and elevated cholesterol levels.
- Trial name
- NCT02065180
- Testing
- commercially available nutrition supplement
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Type 2 Diabetes, Hypercholesterolemia
The Potential Effects and Mechanisms of Flax Lignans on Type 2 Diabetes Mellitus
The purpose of the study is to improving the lipid profile and glucose control in type 2 diabetic patients with supplementation of flax lignans.
- Trial name
- NCT00363233
- Testing
- flax lignans
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese Academy of Sciences
Ischemia, Cardiac Insufficiency
Detection and Treatment of Somatic Disease in Patients With Severe Mental Disease
In Denmark, around 2 % of the population live with severe mental disease. People with severe mental disease live 15-20 years less than the general population.
- Conditions
- Ischemia, Cardiac Insufficiency, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NCT03428308
- Testing
- Screening, Treatment
- Volunteers
- 90 people
- Sponsor
- Intersectoral Research Unit for Health Services
Hypercholesterolemia
RCT for the Chinese Medicine in Treating Hypercholesterolemia
This is a randomized, double-blind, placebo-controlled clinical trial. Eligible subjects will randomized into a treatment group or placebo group.
- Trial name
- NCT06700408
- Testing
- Dachaihu Decoction combined Erzhiwan with variation
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Low-Moderate Hypercholesterolemia
Clinical Trial to Demonstrate the Efficacy of a Dietary Supplement in Decreasing Cardiovascular Risk
This clinical trial seeks to verify the efficacy of a red rice yeast dietary supplement in the decrease of cardiovascular risk, by assessing variables related with cardiovascular risk as levels of cholesterol, triglycerides and…
- Trial name
- NCT03828006
- Testing
- Red Rice Yeast
- Where
- 3 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Bioksan
Familial Hypercholesterolemia
Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. Therapy
The objectives of this post-surveillance study are to continue to evaluate the safety and effectiveness of the H.E.L.P. System. The safety and effectiveness will be assessed by evaluating the occurrence of death, cardiovascular…
- Trial name
- Secura (NCT00916643)
- Testing
- HELP Secura (apheresis treatment)
- Volunteers
- 113 people
- Sponsor
- B. Braun Medical Inc.
Familial Hypercholesterolemia, Atherosclerosis
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia
Familial hypercholesterolaemia (FH) is a genetic disorder characterised by elevated plasma LDLC levels. The causal role of low-density lipoprotein cholesterol (LDLC) in the progression of cardiovascular disease (CVD) is…
- Trial name
- CARDIOMET (NCT05066932)
- Testing
- Additionnal blood samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HDL Cholesterol
Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)
Summary: Background: There is a lot of interest in the function and role of HDL to prevent and mitigate atherosclerosis in patients who are at or near LDLc targets.
- Trial name
- NCT00736463
- Testing
- Simvastatin, Atorvastatin 80 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Hypertension, Type 2 Diabetes
Project WHADE: A Partner-Based Physical Activity Program for Women
This study is designed to test the feasibility and acceptability of a new method for supporting physical activity among women ages 40-65 who have risk factors for cardiovascular disease.
- Conditions
- Hypertension, Type 2 Diabetes, Metabolic Syndrome, Smoking
- Trial name
- NCT06350604
- Testing
- Project WHADE: A Partner-Based Physical Activity Program for Women
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Rowan University
Homozygous Familial Hypercholesterolemia
Evaluate the Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial Hypercholesterolemia
This is a single-arm, open-label study to assess the reduction of low-density lipoprotein cholesterol (LDL-C) by SHR-1918 in patients with homozygous familial hypercholesterolemia (HoFH).
- Trial name
- NCT06009393
- Testing
- SHR-1918
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Hypercholesterolemia
Combination of AB-LIFE Probiotic Plus Monacolin K to Reduce Blood Cholesterol
This randomized study evaluates the effectiveness of a nutraceutical combining billion colony forming units (cfu) of three L. plantarum strains (CECT7527, CECT7528 and CECT7529) and 10 mg of monacolin K in reducing blood…
- Trial name
- NCT04677335
- Testing
- AB-LIFE with Monacolin K
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Hypercholesterolemia, Coronary Heart Disease
Addition of Phytosterols to a Low Phytosterol Diet
Studies have shown that phytosterols will lower LDL cholesterol. Typical diets can contain between 250 to 500 mg of naturally-occurring phytosterols.
- Trial name
- phyteaux-I (NCT00860054)
- Testing
- Different amount of phytosterols are added into diets
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Hypercholesterolemia
Cholesterol Lowering Effect of Cardio-Complement, an Ayurveda Formulation
The aim of this feasibility study was to assess the lipid-lowering effects and safety of a Ayurveda formulation containing Terminalia Arjuna, Withania Sominifera, Garcinia Cambogia and piperine (as bioenhancer)
- Trial name
- NCT04974853
- Testing
- Cardio-complement
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NMP Medical Research Institute
Normal and Mild Hypercholesterolemic Subjects
Long-term Effectiveness Study on Cholesterol-reducing Activity
The purpose of this study is to investigate the effect of consumption of a drinkable low fat fermented milk enriched with 0,8g or 1,6g of plant sterols on reducing plasma cholesterol (LDL-cholesterol) concentration during 12…
- Trial name
- NCT01521169
- Testing
- 1 - low-fat dairy fermented product (drinkable) enriched with plant sterols (0,8g /day equivalent as free sterols)., 2 - low-fat dairy fermented product (drinkable) enriched with plant sterols (1,6g /day equivalent as free sterols)., 3 - low-fat dairy fermented product (drinkable) without plant sterols.
- Where
- Japan
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Danone Japan
Peripheral Arterial Disease, Hypercholesterolemia
Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease
The purpose of this study was to evaluate whether an intensified multifactorial intervention program about cardiovascular risk factors in subjects with peripheral arterial disease (with and without diabetes mellitus), can improve…
- Conditions
- Peripheral Arterial Disease, Hypercholesterolemia, Hypertension, Diabetes Mellitus
- Trial name
- NCT00144937
- Testing
- Stepwise therapy for dyslipidemia, hypertension and diabetes, Dietary recommendations, Increase in physical activity
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital de Sabadell