Clinical trials: High Blood Pressure
Glaucoma
24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol
The proposed crossover study will compare for the first time the quality of 24-hour intraocular pressure control with the combination of travoprost and brinzolamide/timolol compared with travoprost and brimonidine/timolol in…
- Trial name
- NCT00981786
- Testing
- Brimonidine/timolol fixed combination drops added to travoprost, Brinzolamide/timolol fixed combination drops added to travoprost
- Volunteers
- 51 people
- Sponsor
- Aristotle University Of Thessaloniki
Arterial Hypertension
Echocardiographic Analysis by Artificial Intelligence in Hypertension
The objective of this study is to develop artificial intelligence (AI) tools to characterize cardiac remodelling in arterial hypertension through the analysis of routine imaging data (echocardiography) coupled with patient data.
- Trial name
- CARDINAL (NCT06680986)
- Testing
- Clinical cardiac parameters (Arterial pressure, number of anti-hypertensive medications, and the NT-proBNP measurements)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Renal Artery Obstruction, Hypertension, Renal
The HERCULES Trial - A Safety and Effectiveness Study of the Herculink Elite Renal Stent to Treat Renal Artery Stenosis
The purpose of this study is to determine whether the Herculink Elite Renal Stent System is safe and effective in the treatment of renal artery stenosis in patients with less than optimal angioplasty results and uncontrolled…
- Trial name
- HERCULES (NCT00490841)
- Testing
- Herculink Elite Renal Stent System
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Abbott Medical Devices
Gastric Varices Bleeding, Gastric Varices
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices
This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix.
- Conditions
- Gastric Varices Bleeding, Gastric Varices, Portal Hypertension
- Trial name
- CoAGS-GV (NCT07699354)
- Testing
- EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol, EUS-Guided Coil Embolization With Absorbable Gelatin Sponge
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Unity Health Toronto
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension
To investigate the dose-response relationship of DE-104 ophthalmic solution in lowering intraocular pressure (IOP) in subjects with Primary Open-Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT00657579
- Testing
- DE-104 ophthalmic solution, low concentration, DE-104 ophthalmic solution, medium concentration, DE-104 ophthalmic solution, high concentration
- Where
- Japan
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Pulmonary Arterial Hypertension
Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)
To evaluate the change from baseline in pulmonary vascular resistance (PVR), and other hemodynamic parameters, following the addition of ambrisentan to background phosphodiesterase type-5 inhibitor (PDE-5i) therapy in subjects…
- Trial name
- ATHENA-1 (NCT00617305)
- Testing
- Ambrisentan, Sildenafil, Tadalafil
- Where
- 30 sites in United States
- Volunteers
- 38 people
- Sponsor
- Gilead Sciences
Hypertension
Home Blood Pressure SMS Telemonitoring in the Primary Care Setting
Hypertension is a public health problem worldwide, being responsible for 9.4 million deaths worldwide each year, as well as contributing to the burden of coronary, cerebrovascular, renal diseases, among others.
- Trial name
- NCT03524456
- Testing
- Home blood pressure monitoring
- Where
- Peru
- Volunteers
- 40 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Uncontrolled Hypertension
A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension
The main purpose of this study is to assess the serum free cortisol response after ACTH stimulation test at baseline and at Week 8 in participants with uncontrolled hypertension.
- Trial name
- NCT06336356
- Testing
- Baxdrostat
- Where
- 10 sites in United States
- Volunteers
- 48 people
- Sponsor
- AstraZeneca
Hypertension, Aging
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased…
- Trial name
- NCT03821623
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Douglas Seals
Hypertension
Clinical Response of EXTOR (Amlodipine/Valsartan) in Newly Diagnosed Hypertensive Patients.
The American College of Cardiology/American Heart Association hypertension guidelines recommend treatment initiation with dual antihypertensive therapy in adults with stage 2 hypertension (corresponding to grade 1 and 2 in the…
- Trial name
- HELP (NCT06625346)
- Testing
- Fixed-Dose Combination of Amlodipine/Valsartan
- Where
- 2 sites in Pakistan
- Volunteers
- 420 people
- Sponsor
- The Searle Company Limited Pakistan
Hypertension
Rheos® Pivotal Trial
The purpose of this clinical trial is to demonstrate the efficacy and safety of the Rheos system in subjects with hypertension that are resistant to treatment with at least three anti-hypertension agents, one of which is a…
- Trial name
- NCT00442286
- Testing
- Rheos® Baroreflex Hypertension System
- Where
- 44 sites in United States, Germany and 1 more
- Volunteers
- 591 people
- Sponsor
- CVRx, Inc.
Elevated Blood Pressure, Hypertension
The Effects of Pumpkin Seed Oil Supplementation on Cardiovascular Function in Postmenopausal Women.
Postmenopausal women have a higher prevalence of cardiovascular (CV) disease than age-match men. Growing evidence from rat studies have demonstrated CV-protective effects of pumpkin seed oil (PSO).
- Trial name
- NCT03716960
- Testing
- Pumpkin Seed Oil
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Marymount University
Hypertension
An Observational Study to Describe the Effectiveness of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker Combination in the Management of Hypertensive Patients With Elevated Heart Rate and Type 2 Diabetes
To describe the effectiveness of angiotensin-converting enzyme inhibitor and non-dihydropyridine calcium channel blocker single pill combination on systolic blood pressure (SBP) lowering in hypertensive patients with elevated…
- Trial name
- HARVEST-TR (NCT02298556)
- Where
- 23 sites in Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Abbott
Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR
New Taipei City 888 Digital Medical AI Platform for Prevention and Care of the Three Highs and Cardio-Renal-Vascular Diseases
Non-communicable diseases (NCDs), or chronic diseases, are a major public health burden globally and in Taiwan, and control of the "three highs" (hypertension, dyslipidemia, and hyperglycemia) is a national priority.
- Conditions
- Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR, Cardiovascular Disease Risk Factor, Cardiovascular Disease Prevention
- Trial name
- DIGICARE-DREAM (NCT07588256)
- Testing
- Interactive digital modules, Antihypertensive Medication Management
- Where
- Taiwan
- Volunteers
- 4,162 people
- Sponsor
- New Taipei City Medical Association
Portal Hypertension, Cirrhosis, Liver
Perioperative Care of HVPG Measurement (CHESS1904): An International Multicenter Survey
Hepatic venous pressure gradient (HVPG) is an invasive test and requires technical skills of the operator and specialized instruments.
- Trial name
- NCT04121520
- Testing
- Questionnaire
- Where
- 10 sites in Brazil, China and 5 more
- Volunteers
- 200 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Primary Open Angle Glaucoma (POAG), Istent Inject W
Trabecular Microbypass IStent in Patients with Glaucoma
The goal of this clinical trial is to assess the safety and efficacy of phacoemulsification combined with one trabecular micro-bypass stent implantation (phaco-iStent) versus phacoemulsification alone in a Taiwanese population…
- Conditions
- Primary Open Angle Glaucoma (POAG), Istent Inject W, Normal Tension Glaucoma (NTG)
- Trial name
- NCT06630546
- Testing
- first generation iStent (Glaukos, San Clemente, CA, USA) insertion, phacoemulsification
- Where
- Taiwan
- Volunteers
- 71 people
- Sponsor
- Yu-Ting Tsao
Hepatocellular Carcinoma(HCC), Cirrhotic Portal Hypertension
Optimal Treatment on Hepatocellular Carcinoma (HCC) With Cirrhotic Portal Hypertension
There is no consensus about the optimal treatment of hepatocellular carcinoma (HCC) with cirrhotic portal hypertension, While this group of patients are classified as hepatectomy contraindication according to guidelines from…
- Trial name
- NCT01642446
- Testing
- Precise hepatectomy, Combined intervention (chemoembolization/ablation)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-sen University
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Open-Angle Glaucoma, Ocular Hypertension
Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-70
To compare intraocular pressure lowering effectiveness of a combination drug vs. two individual drugs dosed alone.
- Trial name
- NCT00047541
- Testing
- Alcon Investigational Agent
- Where
- United States
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
Brimonidine 0.1% Versus Brinzolamide 1% as Adjunctive Therapy to Latanoprost 0.005%
Patients with glaucoma or ocular hypertension currently being treated with latanoprost 0.005%, and in need of additional IOP lowering will be randomized to receive either brimonidine 0.1% or brinzolamide 1% three-times daily as…
- Trial name
- NCT00440141
- Testing
- latanoprost 0.005% eye drops and brimonidine 0.1% eye drops, latanoprost 0.005% eye drops and brinzolamide 1.0% eye drops
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Allergan