Clinical trials: High Altitude
Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia
Altitude and Outcomes in Pediatric ARDS: A Multicenter Study
This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome…
- Conditions
- Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia, High Altitude Effects
- Trial name
- LARed-ALT (NCT07193771)
- Testing
- Geographic Altitude
- Where
- 20 sites in Bolivia, Chile and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Latin American Pediatric Collaborative Network
Hypoxia-Induced Pulmonary Artery Hypertension
Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
Excessive rise in pulmonary artery pressure induced by low oxygen tension (hypoxia) is one of the factors implicated in high-altitude pulmonary oedema.
- Trial name
- NCT00260819
- Testing
- Bosentan, Bosentam TRACLEER
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Altitude Pulmonary Edema
Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia.
- Trial name
- NCT00559442
- Testing
- Altitude Exposure:
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Pulmonary Edema
Pulmonary Function at High-Altitude
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE).
- Trial name
- NCT00604227
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Cerebral Autoregulation in Lowlanders
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on cerebral autoregulation
- Trial name
- NCT02829255
- Testing
- altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Pulmonary Hypertension
Acute Exposure to High Altitude on Exercise Capacity
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in constant loaded exercise capacity.
- Trial name
- NCT03637153
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Healthy
Hypoxia Impairs Endothelial Function in HAPEs
Aim of the study is to investigate the function of the systemic vascular endothelium in individuals susceptible to high-altitude pulmonary oedema during normoxia and normobaric hypoxia.
- Trial name
- NCT00176007
- Testing
- Hypoxia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Heidelberg University
Altitude, Hypoxia
Tübingen High Altitude Ophthalmology Study
Tuebingen High Altitude Ophthalmology Study to investigate the effects of high altitude on retinal structure and function as well as anterior chamber in regard to acute mountain sickness.
- Trial name
- THAO (NCT01245114)
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
High Altitude Pulmonary Hypertension
The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of aminophylline and ambrisentan in healthy human…
- Trial name
- GQ01 (NCT01530464)
- Testing
- Aminophylline, Ambrisentan, Aminophylline plus ambrisentan
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Thies Schroeder
Orthopedic Surgery, Postoperative Complications
Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions
This study will focus on orthopedic surgery patients from high-altitude regions, utilizing smart wearables and monitoring tools to gather perioperative data, including heart rate, oxygen saturation, sleep quality, stress levels…
- Conditions
- Orthopedic Surgery, Postoperative Complications, High Altitude
- Trial name
- NCT06638658
- Volunteers
- 400 people
- Sponsor
- West China Hospital
High Altitude Pulmonary Edema
Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography
The overall goal of this study is to detect preclinical signs of HAPE by lung ultrasonography and evaluate the effectiveness of acetazolamide at decreasing pulmonary edema by using ultrasound.
- Trial name
- NCT03490916
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vincent Kan
Sleep-Disordered Breathing, Glucose Intolerance
Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing
Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance.
- Trial name
- NCT05462834
- Testing
- Compressed Air, Supplemental Oxygen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
High Altitude Pulmonary Hypertension
The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hypertension
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of theophylline and bambuterol in healthy human…
- Trial name
- NCT01566565
- Testing
- Theophylline and Bambuterol
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Norwegian Armed Forces Medical Service
Gut Microbiota
Temporal Changes in the Gut Microbiota Before and After Migrating to High Altitude
This prospective observational cohort study aims to learn about temporal changes in the gut microbiota before and after migrating to high altitudes in healthy participants.
- Trial name
- NCT05901896
- Testing
- there are no intervention
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
High-altitude Training Adaptations in Adolescent Male Rowers
Effects of a 4-Week Altitude Training on Sport-Specific Performance, Body Composition, and Cardiac and Pulmonary Function in Adolescent Male Rowers
This study aims to investigate the effects of a 4-week altitude training program on adolescent male rowers. The research will examine changes in athletic performance, athletic body composition, athletic cardiac function, athletic…
- Trial name
- NCT07612956
- Testing
- 4-Week Altitude Training
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
Aortic Stenosis, Altitude
Short-term Exposure to High Altitude in Patients With Asymptomatic Aortic Stenosis
Aortic stenosis is a common disease with increasing prevalence due to an aging population. Aortic valve replacement is indicated for symptomatic severe aortic stenosis.
- Trial name
- ASALT (NCT06894550)
- Testing
- Participants will be escorted to high altitude and undergo a series of test
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pulmonary Disease, Cardiovascular Disease
Cardio-Respiratory Health and Indoor Pollution
The aim of this study is to assess in the sample of population resident in the KHUMBU valley (NEPAL): 1. the respiratory function decline by means of spirometry and the respiratory health by means of questionnaire and six-minute…
- Trial name
- NCT01329159
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Ferrara
Diabetes
Protocol for the Evaluation of Dario™ BGMS Performance at Elevated Altitude
The purpose of this study is to assess the performance of the Dario Blood Glucose Monitor (BGMS), at elevated altitudes, by obtaining whole blood fingerstick samples from individuals and analyzing the blood on the Dario Blood…
- Trial name
- NCT02352298
- Testing
- Dario Blood Glucose Monitoring System, YSI Analyzer
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- LabStyle Innovations Ltd.
Covid19, SARS-CoV2 Infection
Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19
In this study, the investigators will examine the extent to which having suffered coronavirus disease 2019 (COVID19) impacts one's sensibility to hypoxia by means of the 'Richalet test'.
- Conditions
- Covid19, SARS-CoV2 Infection, Hypoxia, Altitude
- Trial name
- NCT05167357
- Testing
- COVID19
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne