Clinical trials: Hepatic Transplantation
Liver Transplant, Liver Failure
Hypothermic Machine Perfusion for Liver Graft Preservation
The goal of this clinical trial is to evaluate whether hypothermic machine perfusion improves liver graft preservation and post-transplant outcomes compared to conventional static cold storage in adult patients undergoing liver…
- Trial name
- HOPE-Liver (NCT07595627)
- Testing
- Hypothermic Machine Perfusion, Static Cold Storage
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Liver Transplant Surgery
Fibrinogen in Liver Transplant Subjects
The study is a prospective, multi-centered, unblinded, randomized controlled pilot study. The primary objective is to compare functional hemostatic capacity of Investigational Cryoprecipitate Intercept Fibrinogen Complex (IFC) to…
- Trial name
- FITS (NCT06764927)
- Testing
- Cryoprecipitate Intercept Fibrinogen Complex (IFC), Cryoprecipitate Antihemophilic Factor (AHF)
- Where
- 3 sites in United States
- Sponsor
- Ezeldeen Abuelkasem
Liver Transplantation
Post-Operative Use of Salt Poor Albumin Solution in Resuscitation of Orthotopic Liver Transplant
The purpose of the study is to examine if outcome after liver transplantation is improved by using albumin infusion post-transplantation.
- Trial name
- NCT00842803
- Testing
- Albumin infusion (25% albumin)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hepatectomy
The Use of Technical Vessel Sealing Devices for Recipient Hepatectomy in Liver Transplantation
The surgical technique used in liver transplantation has undergone constant Evolution in an effort towards towards a safe, highly standardized procedure.
- Trial name
- SEALIVE (NCT03323242)
- Testing
- LigaSure, Harmonic Ultrasonic dissector
- Volunteers
- 69 people
- Sponsor
- University Hospital Heidelberg
Incisional Hernia of Anterior Abdominal Wall
Study on the Efficacy of Prophylactic on Lay Mesh in Preventing Post-operative Hernia in Liver Transplant Patients
Study Design: Single-blinded, randomized, prospective clinical trial. Study Population: End-stage liver disease patients' candidates for liver transplantation.
- Trial name
- NCT04512469
- Testing
- Low molecular weight mesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetes, Liver Transplant; Complications
Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Major cardiovascular events are greatest in liver transplant recipients with sustained post-transplantation diabetes1. However, the optimal A1c target after transplantation has not been studied.
- Conditions
- Diabetes, Liver Transplant; Complications, Kidney Transplant Failure
- Trial name
- NCT04216303
- Testing
- hemoglobin A1c
- Where
- United States
- Sponsor
- Methodist Health System
Liver Transplant Disorder
Incentive Spirometer in Liver Transplant Recipients
This study evaluated the effect of adjunctive incentive spirometer on arterial blood gases (ABGs) and early postoperative recovery in liver transplant recipients.
- Trial name
- LT (NCT07318766)
- Testing
- Incentive Spirometry
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Coagulopathy, Liver Transplantation
Clinical Evaluation of the Hemosonics Quantra® Coagulation Monitor in Liver and Multivisceral Transplantation
Severe coagulopathy and operative bleeding are common in liver and multivisceral transplant recipients. This is related to reduced synthesis and function of clotting proteins in end-stage liver disease, thrombocytopaenia…
- Trial name
- NCT04274699
- Testing
- Hemosonics Quantra coagulation monitor
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Recurrent Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8
Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant
This phase II trial evaluates lenvatinib for the treatment of hepatocellular carcinoma (HCC) that has come back (recurrent) after a liver transplant.
- Conditions
- Recurrent Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8
- Trial name
- NCT05103904
- Testing
- Laboratory Biomarker Analysis, Lenvatinib
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Transplant; Complications, Immunosuppression
Effect of Cognitive Therapy on Immunosuppressive Treatment Compliance and Motivation
The study aims to analyze the effects of Mindfulness-Based Cognitive Therapy (MBCT) on the motivation levels and compliance with immunosuppressive therapy of post-liver transplant recipients.
- Conditions
- Liver Transplant; Complications, Immunosuppression, Compliance, Treatment
- Trial name
- NCT06879106
- Testing
- Intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Bitlis Eren University
Liver Cirrhosis, Liver
SALT for Patients With Hepatic Cirrhosis
Hepatitis B virus (HBV) infection is a very difficult public health problem in the world. Patients often experience the trilogy of "hepatitis-cirrhosis-liver cancer".
- Trial name
- NCT06153914
- Testing
- Sequential Adult Left Lateral Liver Transplantation
- Volunteers
- 47 people
- Sponsor
- RenJi Hospital
Hepatitis C Recurrence
A Pilot Study to Examine the Role of Nitazoxanide to Prevent Recurrence of Hepatitis C After Transplantation
Recurrence of Hepatitis C virus infection (HCV) is universal after orthotopic liver transplantation (LTx) and is associated with allograft failure, death and need for re-transplantation.
- Trial name
- NCT01074203
- Testing
- Nitazoxanide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Liver Transplant
Hepato-duodenal Ligament Occlusion and Classic Technique in Liver Transplant
Liver transplantation was historically associated with massive blood loss. Many factors have contributed to the decline in bleeding and transfusion in the past two decades including refinement of surgical techniques, anesthetics…
- Trial name
- NCT04265157
- Testing
- Surgical technique surgical occlusion
- Volunteers
- 50 people
- Sponsor
- Assiut University
Gene Expression, Immunosuppression Conversion
Search for Transcriptional Biomarkers in a Conversion Protocol From Calcineurin Inhibitors to Mycophenolate Mofetil
As is well known, immunosuppressive treatment (IS) after liver transplantation has several and frequents adverse effects that limit the survival of the graft and recipients.
- Conditions
- Gene Expression, Immunosuppression Conversion, Liver Transplantation
- Trial name
- TBCP (NCT01321112)
- Testing
- conversion from CNI to MMF
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Chronic Liver Disease and Cirrhosis
Influence of Donor and Recipient Genetic Polymorphisms on Graft Steatosis After Liver Transplant
MASH (Metabolic Dysfunction-associated Steatohepatitis) is among the most common indications for liver transplantation.The metabolic syndrome persists after liver transplant and is often further exacerbated among MAFLD patients…
- Trial name
- NCT07685353
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis C
Orthotopic Liver Transplant (OLT) Recipients With Hepatitis C Virus (HCV) Under Preemptive Treatment
After a liver transplant, the hepatitis C virus (which destroyed one's own liver) eventually comes back. In many patients, this will eventually cause the loss of the new liver and can also confuse the doctors taking care of them…
- Trial name
- NCT00167557
- Testing
- Pegylated Interferon, Ribavirin, Liver Biopsy
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Liver Transplantation
Efficacy and Safety of Concentration-controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de Novo Liver Transplant Recipients
This trial was designed to address important issues that impact recipients of liver allografts as well as clinicians, ie, renal function, reduction or discontinuation of tacrolimus early post-transplantation, and progression rate…
- Trial name
- RAD (NCT00622869)
- Testing
- Tacrolimus (reduced tacrolimus), Tacrolimus (tacrolimus elimination), Tacrolimus (tacrolimus control)
- Where
- 91 sites in United States, Argentina and 17 more
- Volunteers
- 719 people
- Sponsor
- Novartis Pharmaceuticals
Blood Loss, Surgical
QStat in Liver Transplant
This study will assess the clinical performance of the Quantra System with the QStat Cartridge in the liver transplant population.
- Trial name
- NCT04114253
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Living Donor Liver Transplantation, Liver Transplantation
Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma
This study is supposed to make liver transplantation available for treatment in well selected patients suffering from non-resectable intrahepatic cholangiocarcinoma.
- Conditions
- Living Donor Liver Transplantation, Liver Transplantation, Neoadjuvant Therapy
- Trial name
- LIVINCA (NCT06539377)
- Testing
- Living donor liver transplantation
- Volunteers
- 6 people
- Sponsor
- Jena University Hospital