Clinical trials: Hemodynamics Instability
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Haemodynamic Instability
To Determine the Effectiveness of Saddle Block vs Spinal Anesthesia in TURP
To determine the effectiveness of saddle block vs spinal anesthesia in TURP.
- Trial name
- NCT05285800
- Testing
- 0.5% Hyperbaric Bupivacaine
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hamdard University
Orthopedic Disorder, Hemodynamic Instability
Evaluating The Cardiovascular Effects of Tourniquet Application
The goal of this prospective observational study is to investigate the impact of tourniquet application on cardiac efficiency through the cardiac cycle efficiency parameter and to explore how central regional technique alters…
- Trial name
- NCT06158165
- Testing
- Mostcare (Vytech, Vygon, Padua, Italy)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Merve Şeker
Hemodynamic Instability
The Colder Fluids - Intravenous Infusion of 10 Degrees Celsius Fluids and Its Effects on Circulation and Hemostasis
The aim of this study is to investigate the effect of respectively 10 and 22 degrees Celsius Ringer's lactate solution on the physiological response in healthy adults.
- Trial name
- NCT06622499
- Testing
- Ringer's Lactate
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Out-of-Hospital Cardiac Arrest, Blood Pressure
Blood Pressure and OXygenation Targets After OHCA
This study compares two blood pressure targets and two oxygenation targets in the post-resuscitation care of comatose out-of-hospital cardiac arrets patients.
- Conditions
- Out-of-Hospital Cardiac Arrest, Blood Pressure, Hemodynamic Instability
- Trial name
- BOX (NCT03141099)
- Testing
- Low normal MAP, High normal MAP, Low normal PaO2.
- Where
- 2 sites in Denmark
- Volunteers
- 802 people
- Sponsor
- Jesper Kjaergaard
BPD - Bronchopulmonary Dysplasia, Apnea of Prematurity
Early Caffeine in Preterm Neonates
This is a clinical trial which will investigate whether administration of caffeine, a respiratory stimulant, to preterm babies soon after birth can prevent the need for a breathing tube, or intubation.
- Conditions
- BPD - Bronchopulmonary Dysplasia, Apnea of Prematurity, Hemodynamic Instability, Intubation
- Trial name
- NCT03086473
- Testing
- Caffeine Citrate
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Jennifer Shepherd
Complications; Cesarean Section, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Hemodynamic Effects of Low Dose Spinal Anesthesia for Cesarean Section
We propose to study the effects on hemodynamics (blood pressure, cardiac output, and central venous pressure) of two doses of bupivacaine for spinal anesthesia during cesarean section: a higher dose of 12 mg to a lower dose of…
- Conditions
- Complications; Cesarean Section, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy, Hemodynamic Instability, Personal Satisfaction
- Trial name
- NCT02036697
- Testing
- Bupivacaine 4.5, Bupivacaine 9, Morphine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Hemodynamic Monitoring
Effect of Cardiorespiratory Changes on Carotid Flow Time During Lung Resection Surgery
Cardiorespiratory changes during lung resection surgery, even though generally well tolerated, may lead to hemodynamic compromise, reducing venous return to the heart and hence cardiac output.
- Trial name
- NCT07808749
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Cesarean Section, Hemodynamic Instability
Low-Doses Of Isobaric Bupivacaine On Intraoperative Hemodynamics In Spinal Anesthesia During Cesarean Section
The primary aim of this study was to compare the effects of two different low-dose bupivacaine used in spinal anesthesia on intraoperative hemodynamics in cesarean section operations.Investigators think that low-dose bupivacaine…
- Trial name
- NCT05136040
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Hypotension, Cesarean Section
"Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section"
Spinal anesthesia-induced hypotension is one of the most frequent and clinically significant complications of obstetric anesthesia, occurring in up to 50-80% of parturients undergoing elective cesarean section.
- Conditions
- Hypotension, Cesarean Section, Hemodynamic Instability, Anxiety, Anticipatory
- Trial name
- BREATHE-CS (NCT07494955)
- Testing
- Mindfulness-Based Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aysenur Dostbil
Brain Death
Etiology and Hemodynamic Instability in Brain Death
Brain death is a complex and irreversible condition marked by the cessation of all brain activity. This retrospective study analyzes ICU patients who progressed from initial brain injury to brain death.
- Trial name
- NCT06569992
- Testing
- VIS, TIES
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people
- Sponsor
- Antalya Training and Research Hospital
Trigemino-Cardiac Reflex, Impacted Third Molar Tooth
The Frequency of Trigeminocardiac Reflex During the Extraction of Impacted Mandibular Wisdom Teeth
The goal of this clinical trial is to investigate trigeminocardiac reflex (TCR) formation during surgical extraction of mandibular impacted wisdom teeth in healthy adults.
- Trial name
- NCT06499532
- Testing
- Monitoring and Surgical removal of mandibular impacted wisdom teeth, using Gow-Gates anesthesia technique, Monitoring and Surgical removal of mandibular impacted wisdom teeth, using inferior alveolar nerve block anesthesia technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Hemodialysis Complication, Hemodynamic Instability
MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)
This proposal will measure the effects of mannitol administration versus placebo in hypotensive-prone, adult, maintenance hemodialysis patients with respect to changes in patient symptoms and blood pressure stability.
- Trial name
- NCT04428372
- Testing
- Mannitol, 0.9% saline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Brigham and Women's Hospital
Intraoperative Hypotension, Hemodynamic Instability
AI-Assisted Blood Pressure Control During Anesthesia
This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.
- Trial name
- RL-PRAIS PoC (NCT07123675)
- Testing
- Device: AI Clinical Decision Support System, Procedure: Standard of Care Anesthesia
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Pheochromocytoma, Non-Secretory Adrenal Adenoma
Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma
Pheochromocytomas are tumors of the adrenal gland that develop from cells producing adrenaline and noradrenaline. Consequently, intraoperative blood pressure variations (hypertensive and hypotensive episodes) are characteristic…
- Trial name
- HEMODADRE (NCT06062082)
- Testing
- adrenalectomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Hypovolemia, Fluid Loss
Acetated Ringer´s Solution in Experimental Hypovolemia
Intravenous fluids are often given to increase stroke volume and thereby improve global oxygen delivery. The effect is however often transient, but the effect of a fluid bolus on stroke volume and other hemodynamic variables over…
- Conditions
- Hypovolemia, Fluid Loss, Hemodynamic Instability
- Trial name
- Volu-Flow (NCT05705115)
- Testing
- Ringer acetate, Lower body negative pressure
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Hemodynamic Instability, Surgery
End-expiratory Occlusion Test and Lung Recruitment Maneuver to Assess Fluid responsiVeness In Surgical Patients
The functional hemodynamic test (FHT) called passive leg raising (PLR) has been successfully used for assessing the fluid responsiveness in ICU patients since 2009 and its reliability has been confirmed by three large…
- Conditions
- Hemodynamic Instability, Surgery, Fluid Overload
- Trial name
- ELVIS (NCT03820440)
- Testing
- End-expiratory occlusion test (EEOT), Lung recruitment manovre (LRM)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Humanitas Clinical and Research Center
Delirium, Hemodynamic Instability
Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery
For patients requiring the heart valve replacement surgery, heart function is injured in different degree.Thus, minimizing the impact of the anesthesia drug on the cardiovascular system has important clinical meanings.
- Trial name
- NCT02644980
- Testing
- Propofol, Etomidate, Bispectral Index Monitor
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
Hemodynamic Instability
Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia
The purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean…
- Trial name
- NCT05035485
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Acute Kidney Injury, Hemodynamic Instability
Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
Robotic-assisted laparoscopic prostatectomy (RALP) is the gold standard surgical technique in prostate surgery. Many Robotic-laparoscopic surgical techniques also require the intraoperative deep Trendelenburg position and…
- Trial name
- NCT06000098
- Testing
- Restrictive fluid therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Acibadem University