Clinical trials: Hemodynamic Management
Cardiovascular Risk Factors
Echocardiography Management for Patients Requiring Care for Non-Cardiac Surgery
The growing population of institution patients with heart failure combined with the increasing number of surgical procedures performed each year supports the need for a critical analysis of how to most appropriately manage these…
- Trial name
- EGHEM (NCT01050361)
- Testing
- Transthoracic Echocardiogram (TTE)/Transesophageal Echocardiogram (TEE)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Fluid Management
Hemodynamic Optimization Based on a Dynamic Elastance Protocol
In this study investigators explore the effects of a dynamic elastance guided protocol compared to a stroke volume variation fluid therapy on lactate levels during major abdominal surgery.
- Trial name
- NCT05187273
- Testing
- Elastance Group
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hemodynamic MAP Stability
Closed-loop Control of Vasopressor Administration in Cardiac Surgery
Intraoperative hypotension and blood pressure variability are associated with postoperative complications in surgical patients. The investigators have developed a closed-loop vasopressor (CLV) controller that titrates…
- Trial name
- NCT04232007
- Testing
- closed-loop system for vasopressor administration
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- Erasme University Hospital
Chronic Heart Failure
Effects of Amlodipine in the Management of Chronic Heart Failure
Patients with congestive heart failure are usually treated with a combination of an ACE inhibitor (or an AT1 blocking agent), a diuretic and a beta-blocker.
- Trial name
- NCT00151619
- Testing
- Amlodipine
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Rennes University Hospital
Ischemic Stroke, Revascularization
Cerebral Autoregulation Guiding Blood Pressure Management After Revascularization
This clinical trial aims to learn whether blood pressure (BP) guided by individualized cerebral autoregulation (CA) is safe and provides a better prognosis than a fixed target in patients with ischemic stroke after endovascular…
- Conditions
- Ischemic Stroke, Revascularization, Blood Pressure, Cerebrovascular Insufficiency
- Trial name
- RESCUE-CA (NCT05670028)
- Testing
- Hypotensive Drugs and/or Vasoactive Drugs
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia
Closed-loop Fluid Administration System: Pilot Study to Evaluate Feasibility
The investigators want to test during anesthesia the feasibility of a closed-loop automated fluid replacement system using cardiac output monitoring as the input value.
- Trial name
- NCT01882075
- Testing
- Open loop, Closed-loop
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Hopital Foch
Hemodynamic Instability
Hemodynamic Monitoring During Abdominal Aortic Surgery
This trial investigates the ability of our istitutional algorithm in maintaining a safe hemodynamics during abdominal aorta open surgery, in terms of limitation of intraoperative hypotension incidence
- Trial name
- HEMAS (NCT05478564)
- Testing
- Intraoperative fluids and vasoactive drugs management protocol
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- Humanitas Clinical and Research Center
Anesthesia, Spinal
The Effect of Spinal Anesthesia on Hemodynamics
In this study, it was planned to provide more stable hemodynamics in geriatric patients with low-dose spinal anesthesia. We will compare 7.5mg hyperbaric bupivacaine with 5mg hyperbaric bupivacaine.
- Trial name
- NCT05896631
- Testing
- 7.5 mg hyperbaric bupivacaine, 5 mg hyperbaric bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Central Venous Pressure, Hepatectomy
Preoperative Sildenafil Administration for Hepatectomy
Hepatectomy is an important treatment for liver diseases, and bleeding is one of the most common complications during dissection of the liver parenchyma.
- Conditions
- Central Venous Pressure, Hepatectomy, Hemodynamics Instability, Sildenafil
- Trial name
- NCT06237751
- Testing
- Sildenafil 100 MG
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Surgery Complications
Effects of GDHT (Goal Directed Hemodynamic Therapy) Using a Non-invasive Hemodynamic Monitoring in Elective Neurosurgery
This study aims to assess the safety and efficacy of GDHT using the non-invasive Starling™ SV System in elective neurosurgery. The tested group of patients (n=70) will be compared with a control group (n=70), where hemodynamic…
- Trial name
- NCHGDT (NCT07101991)
- Testing
- Standard monitoring, Goal-Directed Therapy
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Brno University Hospital
Hemodynamic
Use of the Aortic Time-velocity Integral Via Suprasternal Ultrasound to Search Preload Dependence in Paediatric Surgery : Kid's Fluid Management (FM)
After major surgery, fluid overload is associated with an increase of morbidity and mortality. Fluid administration should therefore be given wisely.
- Trial name
- Kid's FM (NCT07099664)
- Testing
- Measurement of aortic Vmax and VTI with suprasternal doppler.
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Hemodynamic Instability During Anesthesia, High Risk Surgery
Focused TTE for Hemodynamic Instable High Risk Patients
Focused transthoracic echocardiography (TTE) is a technique, which allows quick and non-invasive diagnosis and monitoring in hemodynamic instable patients.
- Trial name
- NCT01811914
- Testing
- intraoperative TTE
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Philipps University Marburg
Inotropy, Fluid Management
RESIPI for Reducing Perioperative Major Adverse Cardiac Events
This study aims to evaluate the effect of a novel hemodynamic management and monitoring strategy for reducing cardiac bio marker elevations and major adverse cardiac events.
- Conditions
- Inotropy, Fluid Management, Cardiac Event, Perioperative Cardiac Risk
- Trial name
- RESIPI (NCT03208023)
- Testing
- RESIPI Management Strategy, No intervention
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Vanderbilt University Medical Center
Intraoperative Fluid Management
Advanced Monitoring to Inform and Guide Perioperative Hemodynamic Optimization 1 (AMIGO-1) Study
Serious complications occur in about 16% of major surgeries. Episode of hypotension during surgery may be a leading cause of these complications.
- Trial name
- AMIGO-1 (NCT03477617)
- Testing
- Intraoperative Hemodynamic Algorithm, Usual hemodynamic management
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Aging, Autonomic Nervous System
Effects of a Smart Circuit Exercise Program on Health Outcomes in Community-Dwelling Older Adults
This study was conducted in collaboration with a community-based retirement facility to evaluate the clinical effectiveness of a smart, technology-assisted circuit exercise intervention for community-dwelling older adults.
- Conditions
- Aging, Autonomic Nervous System, Hemodynamics
- Trial name
- NCT07790263
- Testing
- Smart Circuit Exercise Program
- Where
- Taiwan
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Liver Transplantation (LT), End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL)
The goal of the REFIL-2 study is to evaluate the effectiveness of a low splanchnic blood volume restrictive fluid management strategy (a strategy that involves limiting fluid administration and prioritizing the use of medications…
- Trial name
- REFIL-2 (NCT07695363)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Phlebotomy, Optimized cardiac output liberal fluid management strategy
- Where
- 4 sites in Canada
- Volunteers
- 866 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Perioperative Fluid Management, Hemodynamic Monitoring
Study Of Ultrasound Windows For Measuring Inferior Vena Cava Changes Before Cardiac Surgery
This research study will compare two ultrasound methods for assessing the inferior vena cava (IVC), a major vein that reflects intravascular fluid status and cardiac function before and after surgery.
- Conditions
- Perioperative Fluid Management, Hemodynamic Monitoring, Inferior Vena Cava Collapsibility Index, Cardiac Surgery Patients
- Trial name
- THRIVE-CARD (NCT07305051)
- Where
- Canada
- Volunteers
- 283 people
- Sponsor
- Sunnybrook Health Sciences Centre
Septic Shock
Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration
The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient.
- Trial name
- ECHO-VEVA (NCT07438301)
- Testing
- Echocardiogram
- Where
- Thailand
- Volunteers
- 180 people
- Sponsor
- Mahidol University
Heart Failure With Severe Tricuspid Regurgitation
TRICuspid Intervention and Invasive Hemodynamic Monitoring in Heart Failure
Tricuspid regurgitation (TR) is a severe and highly prevalent disease that leads to right-sided heart failure. The severity of TR is associated with increasing morbidity and mortality.
- Trial name
- TRIC-I-HF 2 (NCT07442903)
- Testing
- Pulmonary artery sensor system
- Where
- 2 sites in Germany
- Volunteers
- 45 people
- Sponsor
- LMU Klinikum
Cardiac Surgery
Goal Directed Hemodynamic Management of Acute Heart Failure After Cardiac Surgery in Children
Goal directed therapy (GDT) utilises various monitoring techniques to assess cardiovascular performance and allows for timely interventions based on predetermined algorithms.
- Trial name
- NCT02617602
- Testing
- Goal directed therapy, Control
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation