Clinical trials: Hemodynamic Instability
Orthopedic Disorder, Hemodynamic Instability
Hypotension Prediction Index Based Perioperative Protocolized Hemodynamic Management in Geriatric Orthopedic Surgery
Blood pressure optimization has been considered as a crucial factor to avoid perioperative vital organ hypoperfusion, and perioperative hypotension has been addressed as a risk factor for complications and adverse clinical…
- Trial name
- NCT05274412
- Testing
- hypotension prediction index(HPI), ordinary goal-directed hemodynamic therapy
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- National Taiwan University Hospital
Blood Pressure, Prediction Models
Prediction of Hemodynamic Instability in Patients Undergoing Surgery
Intraoperative hypotension occurs often and is associated with adverse patient outcomes such as stroke, myocardial infarction and renal injury.
- Conditions
- Blood Pressure, Prediction Models, Machine Learning, Hemodynamic Instability
- Trial name
- NCT03533205
- Testing
- Hypotension Probability Indicator
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hemodynamic Instability
Observational Prospective Transesophageal Myocardial Ultrasound Survey
The gold standard in hemodynamic evaluation has been the combined use of echocardiography and right heart catheterization. Fall backs to echocardiography are its time consumption and requirement for specialist interpretation…
- Trial name
- OPTEMUS (NCT02927041)
- Testing
- transesophageal echocardiography (hTEE)
- Sponsor
- The University of Texas Health Science Center, Houston
Intubation; Difficult or Failed, Intubation Complication
Expert Consensus Statements for the Management of a Physiologically Difficult Airway Using the Delphi Method (PDADelphi)
The aim of this study is to review/identify the existing definition and management strategies for a physiologically difficult airway (PDA), to generate expert consensus on the various aspects of managing a patient with a PDA…
- Conditions
- Intubation; Difficult or Failed, Intubation Complication, Hemodynamic Instability, Critical Illness
- Trial name
- PDADelphi (NCT05762068)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sepsis, Abdominal Sepsis
Personalised Real-time Interoperable Sepsis Monitoring (PRISM)
The goal of this prospective observational study is to develop and utilize an Artificial Intelligence (AI) model for the prediction of postoperative sepsis in patients undergoing abdominal surgery.
- Conditions
- Sepsis, Abdominal Sepsis, Infections, Clinical Deterioration
- Trial name
- PRISM (NCT06238180)
- Testing
- PRISM Tool
- Where
- Greece
- Sponsor
- Aisthesis Medical P.C.
Single-ventricle, Fontan Procedure
Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Procedure
After the Fontan procedure applied in patients with a functional or anatomical single ventricle, patients are faced with significant morbidity and mortality risk.
- Conditions
- Single-ventricle, Fontan Procedure, Hemodynamic Instability, Arterial Stiffness
- Trial name
- NCT05011565
- Testing
- Demographic and Clinical Characteristics, Maximal Exercise Capacity, Submaximal Exercise Capacity, Hemodynamic Parameters, Muscle Strength, Muscle Oxygenation, Vascular Function
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Shock, Hemodynamic Instability
Hemodynamic Instability Index: The Impact to Care With a New Predictive Indicator
Philips has developed a new algorithm, called Hemodynamic Instability Rules Based Advisor (HIRBA 2.0) system, for the prediction of hemodynamic instability in critically ill patients, who were not previously known to be at risk.
- Trial name
- HII (NCT02185521)
- Testing
- patient assessment
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- Philips Healthcare
Septic Shock, Hemodynamic Instability
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients
Assessment of fluid responsiveness (FR) is to detect whether patient could benefit from fluid therapy. Mini fluid challenge has been widely used in clinical practice to prevent patients from volume overload.
- Conditions
- Septic Shock, Hemodynamic Instability, Fluid Therapy
- Trial name
- NCT04515511
- Testing
- 4% gelatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Hemodynamic Instability, Hypovolemia
Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness
Hemodynamic instability remains one of the leading causes of morbidity and mortality among critically ill patients in intensive care units. One major contributor to this instability is intravascular fluid deficit.
- Conditions
- Hemodynamic Instability, Hypovolemia, Critical Illness, Pulse Pressure Variation
- Trial name
- NCT07304661
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Izmir Katip Celebi University
Esophagectomy, Epidural; Anesthesia
Erasme Randomized Controlled Trial Surveys Hemodynamic Excursions During Esophagectomy
In our high volume center, the majority of esophagectomy procedures are performed with minimally invasive techniques. The thoracic epidural technique remains the gold standard and homolateral paravertebral catheter is strongly…
- Conditions
- Esophagectomy, Epidural; Anesthesia, Paravertebral Anesthesia, Hemodynamic Instability
- Trial name
- ERASME ULB (NCT06563557)
- Testing
- Hemodynamic changes between epidural and paravertebral during esophagectomy
- Volunteers
- 75 people
- Sponsor
- Erasme University Hospital
Vascular Access, Elevated Jugular Venous Pressure
Ultrasound Assessment of Internal Jugular Vein for Cannulation and Venous Pressure Prediction
This prospective observational study aims to evaluate the diagnostic utility of vascular ultrasound for internal jugular vein (IJV) assessment in adult patients undergoing clinically indicated IJV cannulation.
- Conditions
- Vascular Access, Elevated Jugular Venous Pressure, Hemodynamic Instability
- Trial name
- NCT07773506
- Volunteers
- 100 people
- Sponsor
- Assiut University
CPAP Ventilation, Sedation
Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit
Continuous positive airway pressure (CPAP) is a type of positive airway pressure, where the air flow is introduced into the airways to maintain a continuous pressure to constantly stent the airways open, in people who are…
- Conditions
- CPAP Ventilation, Sedation, Hemodynamics Instability
- Trial name
- CPAP (NCT07888192)
- Testing
- Group DK will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and ketamine (0.5 mg/kg/hr)., Group KP will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and propofol (2-4 mg/kg/hr).(
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Atrial Fibrillation
Atrial Fibrillation Without Hemodynamic Instability in the Intensive Care Unit
Atrial fibrillation (AF) is an abnormal heart rhythm that is common among patients who are admitted to an intensive care unit (ICU) of a hospital.
- Trial name
- AFIB (NCT01461733)
- Testing
- amiodarone
- Volunteers
- 25 people
- Sponsor
- Ottawa Hospital Research Institute
Hemodynamics Instability
Cardiac Output and Other Hemodynamic Changes With Prone Position in Cervical Myelopathy Patients Undergoing Surgery
Positioning a patient in prone position under anaesthesia significantly alters cardiovascular physiology. Cervical myelopathy patients are known to have autonomic dysfunction.
- Trial name
- NCT03027817
- Testing
- Prone Positioning
- Volunteers
- 30 people
- Sponsor
- Dhritiman Chakrabarti
Hemodynamic Instability, Intubation Complication
Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope
The 50% effective concentration of remifentanil by target controlled infusion was not determined for inhibiting the haemodynamic response during double-lumen tube (DLT) intubation.
- Trial name
- NCT03653910
- Testing
- Airtraq, Macintosh
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Traumatic Brain Injury, Blunt Abdominal Trauma
Impact of Traumatic Brain Injury on Hemodynamic Instability in Patients With Blunt Bowel and Mesenteric Injuries
This retrospective cohort study aims to evaluate the impact of traumatic brain injury (TBI) on hemodynamic status in trauma patients with surgically confirmed blunt bowel and mesenteric injuries (BBMI).
- Conditions
- Traumatic Brain Injury, Blunt Abdominal Trauma, Hemodynamic Instability, Shock
- Trial name
- NCT06942091
- Testing
- Traumatic Brain Injury (TBI)
- Volunteers
- 169 people
- Sponsor
- Chang Gung Memorial Hospital
Hemodynamic Instability
Descending Aorta Blood Flow to Guide Fluid Therapy During Surgery
The investigators will perform a clinical observational study of patients undergoing abdominal surgery. The study will be performed at Sykehuset Telemark, Skien.
- Trial name
- NCT05227729
- Testing
- Measurement of blood flow in descending aorta by suprasternal ultrasound Doppler technique, Measurement of blood flow in descending aorta by transoesophageal ultrasound Doppler technique
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Sykehuset Telemark
Acute Kidney Injury (AKI)
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
Renal replacement therapy is a life-saving treatment for patients who have sudden and severe kidney failure. However, some of these patients blood pressure who receive this treatment could become unstable, thus resulting in more…
- Trial name
- MitoHIRRT (NCT05264285)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Hemodynamic Instability
An Optical Neuro-monitor of Cerebral Oxygen Metabolism and Blood Flow for Neonatology
Feasibility trial on the use of a hybrid optical device integrating time-resolved near-infrared spectroscopy (TRS) and diffuse correlation spectroscopy (DCS) for measurement of cerebral oxygen metabolism and blood flow in…
- Trial name
- BabyLux (NCT02815618)
- Testing
- BabyLux Neuro-monitor
- Where
- 2 sites in Denmark, Italy
- Volunteers
- 48 people
- Sponsor
- Gorm Greisen
Hemodynamic Instability, Sepsis
Volemic Resuscitation in Sepsis and Septic Shock
Severe sepsis and septic shock are among the leading causes of morbidity and mortality in patients admitted in the ICU, being responsible for approximately 200000 deaths/year in the USA and 150000 in Europe.
- Conditions
- Hemodynamic Instability, Sepsis, Septic Shock
- Trial name
- NCT02565251
- Testing
- Flotrac/Ev1000, Standard ICU monitorisation, VolumeView/Ev1000
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy