Clinical trials: Helminth Infections
Onchocerciasis
Safety and Efficacy of IDA for Onchocerciasis
This DOLF study will investigate the safety and effectiveness of IDA treatment in persons with onchocerciasis when it is administered after pre-treatment with ivermectin to clear or greatly reduce microfilariae from the skin and…
- Trial name
- DOLF IDA/Oncho (NCT04188301)
- Testing
- IVM w/ ALB, Single dose of IDA, Three daily doses of IDA
- Where
- Ghana
- Volunteers
- 154 people
- Sponsor
- Washington University School of Medicine
Healthy Volunteers
First in Man Clinical Trial of Emodepside (BAY 44-4400)
This study will investigate the safety, tolerability, and pharmacokinetics of single ascending doses of emodepside (BAY 44-4400) in healthy male volunteers.
- Trial name
- NCT02661178
- Testing
- emodepside (BAY 44-4400)
- Where
- United Kingdom
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Celiac Disease
Desensitising Celiac Disease Patients With the Human Hookworm
We have established that the hookworm Necator americanus (Na) dramatically alters the local and systemic immune landscape of the infected human host.
- Trial name
- NaCeD (NCT01661933)
- Testing
- Necator americanus
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- The Prince Charles Hospital
Hookworm
Efficacy and Safety of a Multi-dose Regimen of Mebendazole Against Hookworm in Children
This study is a double-blind randomized clinical trial which aims at providing evidence on the efficacy and safety of two regimens of mebendazole in school-aged children.
- Trial name
- NCT03245398
- Testing
- Treatment with one of the two regimens of mebendazole
- Where
- Tanzania
- Volunteers
- 186 people
- Sponsor
- Jennifer Keiser
Fascioliasis
Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).
The study evaluated safety and tolerability along with clinical outcomes of Egaten administered as per the FDA approved dosing regimen of 2 doses of 10 mg/kg (given approximately 12 hours apart) in Fascioliasis participants (≥ 6…
- Trial name
- NCT04230148
- Testing
- Egaten (Triclabendazole) 250 mg tablets
- Where
- 10 sites in Colombia, Egypt and 3 more
- Volunteers
- 301 people
- Sponsor
- Novartis Pharmaceuticals
Hookworm Infection, Allergy
Development of a Skin Test for the Na-ASP-2 Hookworm Antigen
Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. In a clinical study in previously hookworm-infected adults in Brazil, this protein induced urticarial reactions (rash) in a subset…
- Trial name
- NCT00603889
- Testing
- Na-ASP-2 Skin Test Reagent
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Helminthiasis
Bioequivalence Study of Albendazole 400 mg Tablets in Chinese Population
The purpose of the study is to compare the pharmacokinetic profiles of two Albendazole tablet formulations manufactured under the different granulation processes in healthy Chinese adult males.
- Trial name
- NCT01755637
- Testing
- Albendazole
- Where
- 2 sites in China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hookworm Infection
Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Brazil
Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. In a clinical study in previously hookworm-infected adults in Brazil, this protein induced urticarial reactions (rash) in a subset…
- Trial name
- NCT00939198
- Testing
- Na-ASP-2 Skin Test Reagent
- Where
- Brazil
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Strongyloides Stercoralis Infection, Strongyloidiasis
Treatment of Strongyloides Infection
The aim of this study is to evaluate the serologic response in patients with S. stercoralis infection after treatment with a regimen of two single doses of 200 µg/kg of ivermectin given 2 weeks apart versus a regimen of two…
- Trial name
- TSSI (NCT03605758)
- Testing
- Ivermectin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Albert Einstein College of Medicine
Trichuriasis
Efficacy and Safety of IVM/ALB Co-administration
This study is a double-blind randomized clinical trial conducted with two settings in Africa and one in Asia, namely Côte d'Ivoire, Pemba (Zanzibar, Tanzania) and Lao PDR.
- Trial name
- NCT03527732
- Testing
- Albendazole, Albendazole and Ivermectin
- Where
- 3 sites in Côte d’Ivoire, Laos and 1 more
- Volunteers
- 1,673 people
- Sponsor
- Jennifer Keiser
Hookworm Infections
Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm
The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.
- Trial name
- CHEW_MEB_PEMBA (NCT03995680)
- Testing
- Mebendazole
- Where
- Tanzania
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Trichuris Infection, Helminthiasis
Albendazole Plus High Dose Ivermectin for Trichuriasis in Pediatric Patients
There are four species of intestinal worms collectively known as soil-transmitted helminthiasis (STH): Ancylostoma duodenale and Necator americanus (hookworms), Ascaris lumbricoides (roundworms), and Trichuris trichiura…
- Trial name
- HI4T (NCT04041453)
- Testing
- Ivermectin, Albendazole
- Where
- 2 sites in Argentina, Honduras
- Volunteers
- 176 people
- Sponsor
- Alejandro Krolewiecki
Helminthes; Infestation, Intestinal
Evaluation of Effectiveness of ALBENDAZOLIVERMECTIN Coformulation vs ALBENDAZOLE for Treatment of Intestinal Worms
The purpose of this clinical trial is to evaluate a fixed-dose co-formulation (FDC) of ivermectin and albendazole for the treatment of all Soil Transmitted helminths (STH).
- Trial name
- ALIVE (NCT05124691)
- Testing
- Albendazole and Ivermectin fixed dose coformulation, Albendazole
- Where
- 3 sites in Ethiopia, Kenya and 1 more
- Volunteers
- 1,001 people
- Sponsor
- Barcelona Institute for Global Health
Trichuriasis, Ascariasis
Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC
This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole compared to albendazole monotherapy in school-aged…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- Moxiped (NCT06188715)
- Testing
- Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet
- Where
- Tanzania
- Volunteers
- 224 people
- Sponsor
- Jennifer Keiser
Neurocysticercosis, Epilepsy
Neurocysticercosis: Combined Treatment With Praziquantel (PZQ) and Albendazole (ABZ)
The purpose of this study is to determine if combination drug therapy of praziquantel and albendazole is safe and effective to cure neurocysticercosis.
- Trial name
- NCT00441285
- Testing
- Praziquantel, Albendazole
- Where
- 5 sites in Peru
- Volunteers
- 156 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant
This study is designed to evaluate the safety, reactogenicity, and immunogenicity of Na-GST-1 adsorbed to Alhydrogel® with or without two different dose concentrations of a novel adjuvant, GLA-AF (1 µg or 5 μg) among healthy…
- Trial name
- NCT01385189
- Testing
- 10 μg Na-GST-1/Alhydrogel, 30 μg Na-GST-1/Alhydrogel, 100 μg Na-GST-1/Alhydrogel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Trichuriasis, Hookworm Infections
Albendazole Dose Finding and Pharmacokinetics in Children and Adults
This study is a single-blind randomized clinical trial conducted in rural Côte d'Ivoire. This study aims at providing evidence on the dose-response of increasing oral albendazole dosages against whipworm (T.
- Trial name
- NCT03527745
- Testing
- Albendazole
- Where
- Côte d’Ivoire
- Volunteers
- 700 people
- Sponsor
- Jennifer Keiser
Lymphatic Filariasis
Moxidectin for LF, Cote d'Ivoire (DOLF)
The purpose of this study is to determine whether moxidectin (Mox) will be more effective than ivermectin (IVM) when used in single-dose combination therapies for lymphatic filariasis (LF).
- Trial name
- NCT04410406
- Testing
- Ivermectin, Diethylcarbamazine, Albendazole
- Where
- Côte d’Ivoire
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Schistosomiasis
An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)
The Phase II study consisted of two parts, part 1 is open label, randomized, controlled and exploratory dose finding in children aged between 2 and 6 years infected with S. mansoni.
- Trial name
- NCT02806232
- Testing
- Biltricide (racemate praziquantel) oral tablets, Racemate Praziquantel ODT, Levo Praziquantel ODT
- Where
- Germany
- Volunteers
- 444 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Lymphatic Filariasis
Efficacy of Higher Albendazole and Ivermectin Doses on Wuchereria Bancrofti Microfilarial Clearance in Malawi
Albendazole and ivermectin are currently used in combination for annual mass treatment of lymphatic filariasis in Africa. Although the drugs have been donated, the cost of such programmes is very high and has proven to be a major…
- Trial name
- FED (NCT01213576)
- Testing
- Albendazole 400mg and ivermectin 200mcg/kg, Albendazole and ivermectin, albendazole 800mg and ivermectin 400mcg/kg bi-annually
- Where
- Malawi
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine