Clinical trials: Helicobacter Pylori Infection
Duodenal Ulcer
Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants With or Without Helicobacter Pylori Infection
The purpose of this study is to demonstrate the non-inferior efficacy of TAK-438 versus lansoprazole in the treatment of participants with duodenal ulcer.
- Trial name
- NCT03050359
- Testing
- TAK-438, Lansoprazole, Bismuth-Containing Quadruple Therapy
- Where
- 81 sites in China, Philippines and 2 more
- Volunteers
- 533 people
- Sponsor
- Takeda
Helicobacter Pylori Infection
Triple Therapy With Tegoprazan in H. Pylori Positive Patients_PILOT
This study aims to compare safety and efficacy in an exploratory manner between a Tegoprazan triple therapy and a RAPAE01 triple therapy in H. pylori positive patients.
- Trial name
- NCT04128917
- Testing
- Tegoprazan, RAPAE01
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- HK inno.N Corporation
HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome
Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota.
The Role of Gut Microbiota in the Mechanism of Helicobacter pylori Eradication-Induced Amelioration of Metabolic Syndrome-Related Parameters Study Sponsor: Nanjing First Hospital Principal Investigator: Dr.
- Trial name
- NCT07306988
- Testing
- Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection
Helicobacter Pylori Eradication Rates of Bismuth-containing Quadruple Therapy vs Modified Quadruple Therapy in Korea
South Korea has the highest incidence of gastric cancer worldwide and Helicobacter pylori infection is still prevalent. Clarithromycin-containing triple therapy is still the primary therapy approved by the Korean government.
- Trial name
- NCT03665428
- Testing
- PAMB treatment (modified quadruple therapy), PBMT treatment (bismuth-containing quadruple therapy)
- Where
- South Korea
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Helicobacter Pylori Infection
A Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
- Trial name
- NCT05493644
- Testing
- Remedial treatment within 3 months, Remedial treatment within 3 to 6 months, Remedial treatment within 6 to 12 months
- Volunteers
- 660 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Optimization of Minocycline for Helicobacter Pylori Rescue Treatment
The efficacy of bismuth-containing quadruple therapy with minocycline and metronidazole was not inferior to classical bismuth quadruple therapy for refractory H.
- Trial name
- NCT06561711
- Testing
- Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole
- Where
- 4 sites in China
- Volunteers
- 480 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
H Pylori Infection
Effect of Simethicone on Helicobacter Pylori Detection in Routine Endoscopy
Rationale: Although simethicone improves mucosal clarity, in vitro evidence suggests that its surfactant properties may disrupt bacterial adherence or viability.
- Trial name
- NCT07293234
- Testing
- Simeticone
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Gastric Cancer, Dysplasia Stomach
Endoscopic Surveillance on a High-risk Population for Gastric Cancer in Latin America: The ECHOS Cohort Study.
The goal of this observational study is to evaluate the risk factors associated with incident HGD/GA in patients with CAG with or without IM who are enrolled in endoscopic surveillance, as well as to compare GA incidence…
- Conditions
- Gastric Cancer, Dysplasia Stomach, Atrophic Gastritis, Helicobacter Pylori Infection
- Trial name
- ECHOS (NCT05969444)
- Where
- 2 sites in Chile
- Volunteers
- 685 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Helicobacter Pylori Infection
Efficacy and Safety of Tegoprazan Versus Esomeprazole-containing Bismuth Quadruple Therapy for Eradication of Helicobacter Pylori
This study is a multicenter, randomized, double-blind, double-dummy, phase III study to evaluate the efficacy and safety of tegoprazan versus esomeprazole-containing bismuth quadruple therapy in patients infected with…
- Trial name
- NCT05577468
- Testing
- Tegoprazan
- Where
- China
- Volunteers
- 561 people
- Sponsor
- Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
Caries, Periodontitis
The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection
To elucidate the relationship of chewing miswak sticks on the H. Pylori infection in the oral cavity.The study would be conducted at the Faculty of Dentistry, Kuwait University.
- Trial name
- Miswak (NCT02418520)
- Testing
- Miswak
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
POCone-UBiT-IR300 Pediatric Comparison Study
The purpose of this study is to compare between the POCone® to the UBiT®-IR300 in measuring 13CO2/12CO2 ratio in breath samples when used together with the BreathTek® UBT (urea breath test) Kit and the pUHR-CA web-based software…
- Trial name
- NCT01623154
- Testing
- Pranactin citric solution
- Where
- 3 sites in United States
- Volunteers
- 99 people
- Sponsor
- Otsuka America Pharmaceutical
Helicobacter Pylori Infection
Qingre Huashi Granules Combined the Modified Dual Therapy for Helicobacter Pylori Infection
This is an open-label, randomized controlled trial. The aim of the study is to evaluate the efficacy and safety of the Qingre Huashi Granules combined the modified dual therapy (or called high dose dual therapy) for Helicobacter…
- Trial name
- NCT05364619
- Testing
- Qingre Huashi Granules combined the modified dual therapy, Bismuth containing quadruple therapy
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Helicobacter Pylori Infection
Efficacy of 7-day Versus 14-day Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori（SHARE2302)
Helicobacter pylori (H. pylori) infection is a common global infectious disease of the gastrointestinal tract. Helicobacter pylori eradication can effectively prevent the development of gastric cancer.The researchers collect…
- Trial name
- NCT05997433
- Testing
- 7days bismuth quadruple, 14 days bismuth quadruple
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Peptic Ulcer
Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease
The goal of this clinical trial is to learn if including bismuth in the treatment helps heal stomach and duodenal ulcers caused by Helicobacter pylori (H. pylori) in children.
- Trial name
- NCT07260006
- Testing
- Bismuth quadruple therapy, Triple therapy with PPI + Amoxicillin + Metronidazole
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Helicobacter Infections
Efficacy on Helicobacter Pylori Eradication With Two Antibiotic Regimens
Clinical trial to compare efficacy on eradicating Helicobacter pylori with two antibiotic strategies: sequential with amoxicillin and omeprazole 5 days and clarithromycin with metronidazole and omeprazole 5 days or omeprazole…
- Trial name
- NCT02395458
- Testing
- Sequential therapy, Triple therapy
- Volunteers
- 142 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Helicobacter Pylori Infection, Gut Microbiota
Effect of Probiotics on Gut Microbiota During the Helicobacter Pylori Eradication
Helicobacter pylori (H. pylori) is still infecting more than half of the population in many countries, although the prevalence is decreasing. As a main cause of chronic gastritis, peptic ulcer, and malignant gastric tumors, H.
- Trial name
- NCT05662514
- Testing
- Bifidobacterium animalis subsp. lactis BLa80
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Helicobacter Pylori Infection, Premalignant Lesion
Application of Artificial Intelligence on the Diagnosis of Helicobacter Pylori Infection and Premalignant Gastric Lesion
The aim of this study is to evaluate the impact of artificial intelligence (AI) assistance during routine upper endoscopy on gastric cancer-specific mortality.
- Trial name
- NCT05762991
- Testing
- Routine endoscopy with artificial intelligence-assisted interpretation
- Where
- Taiwan
- Volunteers
- 6,000 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection, Gastritis
Comparison Between High-dose Amoxicillin Dual Therapy and Pylera Quadruple Therapy in the Treatment of Helicobacter Pylori Infection
Helicobacter pylori is a pathogenic bacteria transmitted from individual to individual, being scientifically recognized as an agent who causes persistent inflammatory activity on the gastric mucosa.
- Conditions
- Helicobacter Pylori Infection, Gastritis, Gastric Cancer
- Trial name
- NCT05100446
- Testing
- Amoxicillin - high dose dual therapy, Pylera, Esomeprazole 40mg
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde do Alto Ave, EPE
H. Pylori Infection
Establish Epidemiologic Data of H. Pylori Infection in Children and Adolescents-Using C13-UBT
The aims of this prospective study are: (1) to prospectively investigate the "true" prevalence rate, the acquisition and spontaneous clearance of H.
- Trial name
- NCT00155623
- Where
- Taiwan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
The Diagnostic Validity of the Urea Breath Test
1. To compare the diagnostic accuracy of the 13C-Urea breath test between using the citric acid as test meal and controlled group by endoscopic biopsy methods(histology, CLOtest and H. pylori culture). 2.
- Trial name
- NCT02359942
- Testing
- Citric acid
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital