Clinical trials: Heavy Drinking, open to volunteers
MBSR, Young Adults
A Reinforced Mindfulness-Based Intervention to Reduce Problematic Drinking Among Hispanic Emerging Adults
This study is a trial to evaluate a mindfulness program designed for Hispanic young adults. Participants will be randomly assigned to one of two groups: (1) an in-person, 8-week mindfulness program (one 1.5-hour session per week…
- Conditions
- MBSR, Young Adults, Heavy Episodic Drinking
- Trial name
- Mindfulness (NCT07192094)
- Testing
- Mindfulness Sessions - 8 Week Program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Florida International University
Heavy Drinking, Metabolic Syndrome
Aerobic Exercise Addition to Cognitive Behavioural Treatment in Impotence Metabolic-syndrome Drinkers
Cognitive Behavioural Treatment is used as treatment for Heavy Drinking, Impotence, and Metabolic Syndrome. The efficacy of adding aerobic training to this treatment is not tested till now.
- Conditions
- Heavy Drinking, Metabolic Syndrome, Impotence
- Trial name
- NCT07277673
- Testing
- aerobci physical training and cognitive behavioural treatment, Cognitive behavioural treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Alcohol Use Disorder
Pilot Study: Effects of Nimodipine on Alcohol Drinking
This is an open label trial aiming to recruit 5 non-treatment seeking adults with Alcohol Use Disorder. All will participate in an alcohol drinking paradigm (ADP) lab session at the Hospital Research Unit (HRU) at Yale-New Haven…
- Trial name
- NCT06900998
- Testing
- Nimodipine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Heavy Drinking
Study of Nitrate-Rich Juice on Cognitive Function in Heavy Alcohol Drinkers: a Two-Stage Adaptive Design Real-World Clinical Trial
It is known that alcohol consumption can lead to cognitive impairment and dysregulation of inflammatory responses. A preliminary randomized controlled trial conducted by our research team has suggested that nitrate may improve…
- Trial name
- NCT06777459
- Testing
- Nitrate-rich beetroot juice
- Volunteers
- 43 people
- Sponsor
- Peking University Sixth Hospital
Alcohol Consumption, Heavy Drinker
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
- Conditions
- Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
- Trial name
- NCT06136195
- Testing
- Mavoglurant
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Heavy Drinking
Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers
The present study will assess the acceptability and feasibility of a brief intervention designed to help young heavy drinkers reduce their alcohol consumption.
- Trial name
- NCT07516873
- Testing
- Active RAVANS, Brief Mindfulness-Based Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cambridge Health Alliance
Bipolar Disorder, Alcohol Use Disorder
N-Acetylcysteine for Bipolar and Alcohol Use Disorders
This study will evaluate N-acetylcysteine (NAC) in adults with bipolar disorder and alcohol use disorder. Participants will be randomly assigned to receive NAC or matched placebo for 28 days.
- Trial name
- NCT07913542
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Imaging CRF X NOP Interactions in Alcohol Use Disorder
This positron emission tomography imaging study uses [C-11]NOP-1A and hydrocortisone to image stress-modulating proteins in heavy drinking alcohol use disorder (AUD) subjects and healthy controls (HC).
- Trial name
- NCT07612631
- Testing
- Baseline [C-11]NOP-1A PET scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET scan
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University
Alcohol Use Disorder
Effects of Nimodipine on Alcohol Drinking
This is a randomized placebo-controlled trial (RCT). Participants will be non-treatment seeking adults, 21-50 years of age, with Alcohol Use Disorders.
- Trial name
- NCT07681869
- Testing
- Nimodipine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Binge Eating, Binge Drinking
Brief Binge Eating and Drinking Online Intervention
This pilot project targets both binge drinking and binge eating behavior in college students through a mobile-based online program that provides students with evidence-based intervention material designed to reduce the incidence…
- Trial name
- NCT06326099
- Testing
- Brief Online Binge Eating and Drinking Intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Heavy Drinking, Mental Health Issue
Affirmative Psychotherapy for Sexual Minority Women's Mental and Behavioral Health
The purpose of this 2-arm randomized controlled trial is to assess the efficacy of a 10-session lesbian, gay, bisexual, transgender, and queer (LGBTQ)-affirmative cognitive-behavioral psychotherapy (CBT) delivered via telehealth…
- Trial name
- EQuIP (NCT05509166)
- Testing
- LGBTQ-affirmative Cognitive Behavioral Therapy, LGBTQ-affirmative Treatment-As-Usual
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy Volunteer, Alcohol Consumption
Phosphatidylethanol and Other Ethanol Consumption Markers
This study is intended to help the investigators understand how a biomarker found in the blood may be used to better identify the quantity and different patterns of alcohol use.
- Trial name
- NCT06747364
- Testing
- Alcohol (Ethanol)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alcohol Use Disorder
Cerebellar Involvement in Alcohol Use Disorder (AUD)
The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1.
- Trial name
- NCT05732207
- Testing
- cerebellar transcranial direct current stimulation
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder, Alcohol Use, Unspecified
Drinking, Acetate, and Stress
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry.
- Conditions
- Alcohol Use Disorder, Alcohol Use, Unspecified, Heavy Drinker, Alcohol Use Disorder, Moderate, in Sustained Remission
- Trial name
- NCT06584448
- Testing
- Deuterium Metabolic Imaging with deuterated acetate tracer
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Heavy Drinking
Helpline Pilot Factorial Trial
The pilot factorial trial will (1) evaluate feasibility, acceptability, and fidelity of the intervention components (Aim 2.1), and (2) collect proof-of-concept data on the impact of the components on the proximal (motivation…
- Trial name
- NCT06591026
- Testing
- Standard Helpline (SH), Motivational Interviewing (MI), Coping Skills Training (CST)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Opioid Use Disorder, Alcohol Intoxication
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
The goal of this clinical trial is to examine whether individuals with co-occurring opioid use disorder and alcohol use (OUD+ALC) experience heightened pain sensitivity, pain-related negative affect, and greater alcohol…
- Conditions
- Opioid Use Disorder, Alcohol Intoxication, Pain
- Trial name
- NCT07894276
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Insomnia, Alcohol; Harmful Use
Sleep as a Mechanism of Change in Alcohol Use
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
- Trial name
- ReTRAIN (NCT06286774)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Alcohol Use Disorder
A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder
The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and/or TMS intervention in individuals seeking treatment for Alcohol Use Disorder.
- Trial name
- CNT (NCT05621538)
- Testing
- Realtime fMRI Neurofeedback - Active, TMS - Active
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Auburn University
Alcohol Use Disorder, Alcoholism
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)
The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT07216872
- Testing
- Deep TMS (DTMS)
- Where
- 11 sites in United States, Israel and 1 more
- Volunteers
- 186 people
- Sponsor
- Brainsway