Clinical trials: Heartburn
Dental Plaque
Effect of a Propolis Tablet on the Saliva and the Amount of Adolescent Dental Plaque Microbes
The aim of the present study was to evaluate the effect of a xylitol containing propolis tablet on the salivary pH, total microorganisms count and soluble and insoluble extracellular polysaccharide concentration of the dental…
- Trial name
- NCT03394729
- Testing
- Propolis tablet to limit dental biofilm, Xilytol tablet to limit dental biofilm
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Gastroesophageal Reflux Disease
Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD
Gastroesophageal reflux disease (GERD) is a chronic condition, which may significantly decrease patients' quality of life due to the typical symptoms - heartburn and regurgitation.
- Trial name
- OGIG-130-1 (NCT01882088)
- Testing
- Mucofalk
- Where
- Russia
- Volunteers
- 36 people
- Sponsor
- Russian Academy of Medical Sciences
Heartburn
Efficacy and Safety of Itopride vs Placebo in Heartburn
The purpose of this study is to evaluate the effects of itopride in patients with heartburn.
- Trial name
- NCT00382577
- Testing
- Itopride
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Forest Laboratories
Chronic Hepatitis b
An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Entecavir or Tenofovir in Patients With Chronic Hepatitis b Who Have Received Nucleoside (Acid) Therapy
This is an open label, randomized, multi-center, comparative study. Subjects will be screened prior to study entry to establish eligibility.
- Trial name
- NCT04157257
- Testing
- TDF tablet, Entecavir Tablet, QL-007
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Gastroesophageal Reflux, Heartburn
Open Label Study Evaluating Different Dosing Regimens of Rabeprazole in Gastro-esophageal Reflux Disease (GERD) Patients With Night-time Heartburn Symptoms.
The purpose of this study is to evaluate the effect of each of the rabeprazole treatment regimens on nocturnal heartburn symptoms.
- Trial name
- NCT00553449
- Testing
- rabeprazole
- Volunteers
- 48 people
- Sponsor
- Janssen-Ortho Inc., Canada
Gastroesophageal Reflux, Regurgitation
A Study of Breath Testing for Small Intestinal Bacterial Overgrowth
Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Heartburn
- Trial name
- NCT05976165
- Testing
- Breath Testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Caffeine Dependence, Anxiety
Remote Guided Caffeine Reduction
The purpose of this online research study is to determine whether or not a gradual caffeine reduction program developed at Johns Hopkins can help people reduce their caffeine use.
- Conditions
- Caffeine Dependence, Anxiety, Sleep Disturbance, Gastrointestinal Dysfunction
- Trial name
- NCT04560595
- Testing
- Caffeine Reduction Manual
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
GERD
Image-Enhanced Endoscopy (IEE) for Diagnosis of Non-Erosive Reflux Disease
When treating persistent heartburn from gastroesophageal reflux disease (GERD) that does not respond to conventional treatment (a class of medications called proton pump inhibitors), it is important to be able to distinguish…
- Trial name
- NCT02629081
- Testing
- Controls & Cases
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Loren Laine
GERD
PPI Versus Placebo in Severe Functional Heartburn
Proton Pump Inhibitors are no better than placebo in relieving GERD symptoms in patients with functional Heartburn.
- Trial name
- NCT00222989
- Testing
- PPI
- Where
- United States
- Sponsor
- University of Southern California
Gastroesophageal Reflux
A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn
The purpose of this study is to determine whether Dexlansoprazole once daily (QD) is effective in treating patients with night heartburn.
- Trial name
- NCT00627016
- Testing
- Dexlansoprazole
- Where
- 43 sites in United States
- Volunteers
- 305 people
- Sponsor
- Takeda
Bladder Cancer
Ethacrynic Acid Elimination in Non-Muscle Invasive Bladder Cancer Patients Undergoing Transurethral Resection
Phase 1 study to provide quantitative characterization of the renal elimination of ethacrynic acid and metabolites in patients with non-muscle invasive bladder cancer (NMIBC) at the time of transurethral resection of bladder tumor
- Trial name
- NCT02852564
- Testing
- Ethacrynic Acid
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eugene Lee, MD
Erosive Reflux Disease
Study to Evaluate the Efficacy and Safety of Tegoprazan in ERD Patients With Nighttime Heartburn and Sleep Disturbance
This study aims to compare the nighttime heartburn and sleep disturbance improvement effect of Tegoprazan 50mg and Eomeprazole 40mg in patients with ERD patients.
- Trial name
- NCT04309916
- Testing
- Tegoprazan, Esomeprazole
- Where
- South Korea
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Heartburn
Efficacy of Esomeprazole in Patients With Frequent Heartburn
This study will investigate the efficacy of esomeprazole 20 mg once a day in the treatment of frequent heartburn
- Trial name
- NEXT1 (NCT01370525)
- Testing
- Esomeprazole
- Where
- 10 sites in United States
- Volunteers
- 340 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease, Esophageal Cancer
Decision Aid for Gastroesophageal Reflux Disease Management
The study is to test a decision aid that is designed to help patients make decision regarding management of their gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease, Esophageal Cancer, Barrett's Esophagus
- Trial name
- NCT01641887
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Heartburn
Symptom Control Satisfaction With Proton Pump Inhibitor Regimen
The overall aim of this study is to assess if patients with persistent gastroesophageal reflux disease (GERD) symptoms receiving sub-optimal omeprazole dosing experience improvement in GERD symptoms when prescribed an optimal…
- Trial name
- NCT02623816
- Testing
- Optimal Dosing of Omeprazole
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Non-erosive Reflux Disease
Comparing Omeprazole With Fluoxetine for Treatment of Non Erosive Reflux Disease and Its Subgroups: a Double-blind Placebo-controlled Clinical Trial
Gastro-esophageal reflux disease (GERD) is highly prevalent, affecting up to 20% of the adult population in North America. Up to 70% of GERD patients have non-erosive reflux disease (NERD), a term used to describe symptoms…
- Trial name
- NCT01269788
- Testing
- Fluoxetine, Omeprazole
- Where
- Iran
- Volunteers
- 144 people
- Sponsor
- Tehran University of Medical Sciences
Erosive Esophagitis, Heartburn
A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily
The primary objective is to determine the pharmacokinetics (PK) of vonoprazan in breast milk of healthy lactating women who have received vonoprazan administered once daily or vonoprazan 20 mg administered twice daily for 4…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Nonerosive Gasroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06391177
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Phathom Pharmaceuticals, Inc.
GERD, Barretts Esophagus
In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter
The purpose of this study is: To study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure profile generated by the smooth…
- Trial name
- NCT00737802
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Malignant Neoplasm
Extended Use of Sodium Bicarbonate in Patients With Cancer
This pilot phase I trial studies the safety of long-term use of sodium bicarbonate in patients with cancer. Sodium bicarbonate may neutralize tumor acidity and as a result may inhibit the spread of the tumor to other parts of the…
- Trial name
- NCT02531919
- Testing
- Sodium Bicarbonate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arizona
Chronic Hepatitis b
A Cohort Study on Long-term Clinical Outcomes of Antiviral Therapy in Patients With Chronic Hepatitis B and Cirrhosis
This was a retrospective observational cohort study. The patients with chronic hepatitis B and cirrhosis who were treated with antiviral therapy in the Second Department of Liver Disease, Beijing Ditan Hospital, Capital Medical…
- Trial name
- NCT04301908
- Testing
- interferon
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Ditan Hospital