Clinical trials: Heart Surgery
Thromboses, Deep Vein, Tranexamic Acid Adverse Reaction
Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery
In recent years, the lysine analogs tranexamic acid (TXA) has gained wide use in cardiac surgery as a blood-sparing agent. However, the safety of the drug and its impact on overall outcomes of cardiac surgery remains debated.
- Trial name
- NCT03838328
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 360 people
- Sponsor
- SHI Jia
Congenital Heart Disease, Post Cardiac Surgery
Transitional Telehealth Home Care: REACH
The investigators want to determine if additional, increased contact with infants and families discharged to home after cardiac surgery improves infant and parent outcomes as compared to usual care.
- Trial name
- NCT01941667
- Testing
- Daily Messages, Virtual Home Visits, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiac Surgery, Adult
Erector Spinae Plane Block and Pain Management in Cardiac Surgery
Evaluation of the benefit effects of Peri-Operative analgesia by Continuous Bilateral Erector Spinae Plane block(ESP) for Open Cardiac Surgery: A case series prospective study with a comparison a retrospective case series (Before…
- Trial name
- ESPCATHEART (NCT03541837)
- Testing
- Ropivacaine
- Where
- Vietnam
- Volunteers
- 40 people
- Sponsor
- Vinmec Healthcare System
Coronary Artery Bypass Surgery, Stable Angina
Optimal Dose of Acetylsalicylic Acid After Coronary Artery Bypass Grafting
This is a single-center, open-label, randomized controlled trial. Patients with stable angina pectoris without use of dual antiplatelet therapy or anticoagulation therapy scheduled for coronary artery bypass grafting (CABG) at…
- Trial name
- NCT02482857
- Testing
- Acetylsalicylic acid
- Volunteers
- 45 people
- Sponsor
- Karolinska University Hospital
Moderate or Severe Mitral Regurgitation
Novel 3-dimensional Echocardiographic Quantification of Mitral Regurgitant Volume
The goal of this observational study is demonstrate that a novel artificial intelligence based software for the quantification of the mitral regurgitation on 3-dimensional transesophageal echocardiography (3D CFQ) is more…
- Trial name
- AIM_3D (NCT07528781)
- Testing
- analysis of the performance of an artificial intelligenced based software for analysis of 3D tranesophageal echocardiography data
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Germans Trias i Pujol Hospital
Cardiac Surgery Subjects, Pressure Ulcer Prevention
Polyurethane Foam-Pink Pad (RCT) Use in OR
King Abdullah medical city has a cardiac center, and a lot of open-heart surgeries are performed there, and both polyurethane foam (pink Pad) and Mepilex dressing are applied to those patients.
- Conditions
- Cardiac Surgery Subjects, Pressure Ulcer Prevention, Pressure Ulcer of Skin, Pressure Ulcer
- Trial name
- pink-pad (NCT06790277)
- Testing
- Mepilex Border Sacrum dressings, Polyurethane foams (Pink Pad)
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Abdullah Medical City
Pediatric Cardiac Surgery
Influence of Inotropic Choice on Morbidity and Mortality in Complex Pediatric Heart Surgery
Our study is based on the observation that management of the cardiopulmonary by-pass withdrawal in pediatric heart surgery is quite variable between medical teams.
- Trial name
- CHUBpedCSino (NCT04380181)
- Testing
- dobu
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Brugmann University Hospital
Cardiac Surgery
Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%.
- Trial name
- NCT05885230
- Testing
- pecto intercostal fascial block using bupivacaine 0.25%, lidocaine infusion
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Coronary Artery Bypass Graft With or Without ECC
Study Of Factors Favoring The Onset Of Novo Atrial Fibrillation In The Immediate Aftermath Of Coronary Artery Bypass Surgery
Before la surgery: Transthoracic cardiac echography will be done systematically, to measure among other things the size of the left atrium.
- Trial name
- NCT02042547
- Testing
- Tissue samples from the right atrium, Blood samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Heart Failure
Stimulation of the Diaphragm in Patients With Severe Heart Failure Following Heart Surgery
This study examines whether a permanent stimulation of the diaphragm improves left ventricular function in patients with severe heart failure following heart surgery.
- Trial name
- NCT00769678
- Testing
- Stimulation of the diaphragm
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Luzerner Kantonsspital
Aortic Valve Stenosis, Symptomatic Aortic Stenosis
Structured Shared Decision Making for Patients Undergoing SAVR or TAVR
Transcatheter aortic valve replacement (TAVR) is a well-established alternative to surgical aortic valve replacement (SAVR) for the treatment of patients with severe aortic stenosis regardless of surgical risk.
- Trial name
- TOGETHER (NCT05711186)
- Testing
- Structured SDM, Usual Care
- Where
- 2 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Congenital Heart Disease
Fresh Frozen Plasma and Plasmalyte ® for Priming Cardiopulmonary Bypass in Infants and Children
Coagulation abnormalities after pediatric open-heart surgery are complex and very often multifactorial. Besides the cardiopulmonary bypass (CPB), the congenital pathology and the coagulation tests during CPB, the younger age has…
- Trial name
- NCT02567786
- Testing
- Surgery with CPB, Fresh Frozen Plasma, Plasmalyte
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Femur Fracture, Spinal Anesthesia
Echocardiography Examination Of The Cardiac Effects Of Different Regional Anesthesia Methods
Nerve blocks applied with neuraxial anesthesia and ultrasonography are used for many operations today. Neuraxial blocks cause varying degrees of decrease in the blood pressure level of the patients.
- Conditions
- Femur Fracture, Spinal Anesthesia, Lumbar Plexus Block
- Trial name
- NCT04975386
- Testing
- Transthoracic echocardiogram
- Volunteers
- 62 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Three Vessel Coronary Artery Disease
Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery
This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients…
- Trial name
- NCT01840969
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Yonsei University
Bypass Surgery, Arrythmia
Parasternal Intercostal Plane Catheter for Pain Control After CABG Surgery
Coronary artery bypass graft (CABG) surgery performed via sternotomy (incision of the breastbone) can cause severe pain after surgery; this can slow recovery and increase the need for opioid pain relievers.
- Conditions
- Bypass Surgery, Arrythmia, Postoperative Pain
- Trial name
- PIP-PAIN (NCT07759570)
- Testing
- Parasternal blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Koc University Hospital
Continuous Lactate Measurements, Cardiosurgery
Lactate in High-risk Cardiac Surgery
The major combined interventions are between challenging and high-risk aspects of current cardiosurgical practice. The results of operation may be hampered by unexpected anatomic and technical features influencing the surgical…
- Trial name
- CLM-CARD (NCT02568969)
- Testing
- Eirus continuous lactate monitor
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Northern State Medical University
Thoracic, Surgery
Non Invasive Cardiac Output Evaluation With Starling SV for Lung Elective Surgery
Intraoperative hemodynamic optimization decreases postoperative complications and length of stay in high risk patient. Therefore, continuous monitoring of cardiac output (Qc) is recommended to guide fluid management.
- Trial name
- NICOLE (NCT04251637)
- Testing
- Cardiac output monitoring with Starling SV.
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Disease
Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery
The goal of this project is to determine whether the use of tranexamic acid, a clot-promoting drug, applied topically over the heart in coronary artery bypass graft surgery (CABG) will reduce post operative blood loss.
- Trial name
- NCT01519245
- Testing
- Tranexamic Acid, normal saline
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Acute Kidney Injury
Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery
This is a randomized, open label study to investigate vasopressin versus phenylephrine as a first line pressor in cardiac surgery.
- Trial name
- NCT04602767
- Testing
- Vasopressin, Phenylephrine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
Coronary Artery Disease, Stable Angina
The Effect Of Ticagrelor On Saphenous Vein Graft Patency In Patients Undergoing Coronary Artery Bypass Grafting Surgery
In the POPular CABG study we investigate if the addition of ticagrelor, a drug that inhibits blood platelets from clotting, to treatment with aspirin will reduce the rate of saphenous vein graft occlusion as assessed with…
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- POPular CABG (NCT02352402)
- Testing
- Ticagrelor
- Where
- 6 sites in Netherlands
- Volunteers
- 487 people
- Sponsor
- J.M. ten Berg