Clinical trials: Heart Failure Chronic
Heart Failure With Reduced Ejection Fraction (HFrEF)
Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure
This is a single-center, randomized, open-label, no-profit interventional trial designed to evaluate the effectiveness of a telemedicine-based follow-up strategy compared with standard ambulatory care in patients with newly…
- Trial name
- TELEHEART (NCT07518030)
- Testing
- Telemedicine-based follow-up, Standard follow-up
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Congestive Heart Failure, Diabetes
Does Access to an EHR Patient Portal Influence Chronic Disease Outcomes?
The purpose of this study is to determine if patients with congestive heart failure, diabetes or secondary cardiovascular diseases, who access HealthMedia's online tailored behavior change programs on the electronic health record…
- Conditions
- Congestive Heart Failure, Diabetes, Cardiovascular Disease
- Trial name
- NCT00147706
- Testing
- Tailored Healthmedia programs on EHR Patient Portal
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Robert Wood Johnson Foundation
Chronic Heart Failure
Improving Knowledge To Efficaciously RAise Level of Contemporary Treatment in Heart Failure (
Heart failure (HF) remains to have a poor outcome. Even though recent advances in HF led to a reduction of morbidity and mortality, improvement in outcome is much less than expected based on large randomized trials.
- Trial name
- INTERACTinHF (NCT02463786)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Maastricht University Medical Center
Congestive Heart Failure
Placebo Controlled, Randomized, Double-blind, Multi-center Study to Investigate the Efficacy and Tolerability of BAY58-2667
The purpose of this study is to assess a dose titration scheme, of a new drug (BAY58-2667) given intravenously, to evaluate if this is safe and can help to improve the well-being, symptoms (e.g.
- Trial name
- NCT00559650
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 72 sites in United States, Canada and 15 more
- Volunteers
- 150 people
- Sponsor
- Bayer
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF
This study was conducted to evaluate the safety and pharmacokinetics of an echocardiographic contrast agent, AI-700, in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and/or congestive heart failure…
- Trial name
- NCT00156780
- Testing
- AI-700
- Where
- United States
- Sponsor
- Acusphere
Atrial Fibrillation, End-stage Kidney Disease
Compare Apixaban and Vitamin-K Antagonists in Patients With Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD)
The Study is an open-labeled, randomized controlled trial, phase IIIb. Its objective is to assess the safety of the factor Xa inhibitor apixaban versus the vitamin-K antagonist (VKA) phenprocoumon in patients with NVAF and ESKD…
- Trial name
- AXADIA (NCT02933697)
- Testing
- Apixaban, Phenprocoumon
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Atrial Fibrillation Network
Heart Failure, Congestive Heart Failure
Evaluation of the Safety and Efficacy of the 2-lead OPTIMIZER® Smart System
This is a multicenter, prospective, single-arm study of the Optimizer Smart System with 2-leads
- Conditions
- Heart Failure, Congestive Heart Failure, Chronic Heart Disease, CHF
- Trial name
- FIX-HF-5C2 (NCT03339310)
- Testing
- Optimizer Smart System with 2-leads
- Where
- 10 sites in United States, Germany
- Volunteers
- 60 people
- Sponsor
- Impulse Dynamics
Heart Failure
Renal Denervation in Patients With Chronic Heart Failure and Resynchronization Therapy
Chronic heart failure is becoming more and more common disease and activation of sympathetic nervous system plays a crucial role in its development.
- Trial name
- NCT02329145
- Testing
- renal denervation
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Jagiellonian University
Cardiovascular Diseases, Chronic Heart Failure
FLOWS-HF : Feasibility of Lymphatic Offloading With Stenting in Heart Failure
The main objective is to evaluate the safety of lymphatic decompression in heart failure. The research hypothesis is that lymphatic decompression is safe and feasible in heart failure patients with recurrent congestion despite on…
- Trial name
- FLOW-HF (NCT06554912)
- Testing
- Lymphatic Decompression
- Sponsor
- University Hospital, Grenoble
Chronic Heart Failure
Telemedical Interventional Monitoring in Heart Failure
Superiority of additional Remote Patient Monitoring in patients with CHF In comparison to usual care in terms of: reduction of mortality rate reduction of hospitalizations increasement of patients' quality of life
- Trial name
- TIM-HF (NCT00543881)
- Testing
- Remote patient monitoring (Partnership for the Heart), Usual care group
- Where
- 2 sites in Germany
- Volunteers
- 710 people
- Sponsor
- Charite University, Berlin, Germany
Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD)
Assessment of Plasma and NGAL for the Early Prediction of Acute Kidney Injury After Cardiac Surgery in Adults Study
The study aims to recruit 156 (54 Acute Kidney Injury (AKI);102 non-AKI) patients undergoing Cardio pulmonary bypass (CPB) surgery, including those with Chronic Kidney Disease (CKD) and multiple co-morbidities.
- Conditions
- Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), Estimated Glomerular Filtration Rate (eGFR)
- Trial name
- NGAL (NCT02733328)
- Testing
- CPB Surgery
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Heart Failure With Preserved Ejection Fraction, End Stage Renal Disease on Dialysis
EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease
The presence of CKD has been linked to the development of HFpEF. Currently, the treatment for HFpEF is limited. SGLT2i are one of the few drug classes that have proven efficacy in HFpEF in randomized controlled trials.
- Trial name
- EMPA-PRED (NCT06249945)
- Testing
- Empagliflozin 25 MG
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Heart Failure, Sleep Apnea
Treatment of Cheyne Stocks Respiration With Adaptive Servo Ventilation and Bilevel Ventilators in Patients With Chronic Heart Failure
The overall purpose of this study is to determine the effects of adaptive servo ventilation (ASV) and bi-level ventilators on Cheyne-Stocks respiration (CSR).
- Trial name
- NCT00725595
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
HF - Heart Failure
A Dynamic Evaluation of Chronic Heart Failure Prognosis: the MECKI Score
The project is dedicated to the improvement of our capability to provide a precise and personalized prognosis in heart failure (HF) patients in stable conditions.
- Trial name
- MECKI (NCT06070519)
- Testing
- CPET and related variables evaluation
- Where
- 4 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Centro Cardiologico Monzino
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Heart Failure, Heart Failure NYHA Class III
Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF)
The Narrative Intervention for Chronic Illness-Heart Failure (NICI-HF) offers an asynchronous interactive text behavioral health intervention to advance behavioral health equity by facilitating access to care for people adjusting…
- Conditions
- Heart Failure, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NICI-HF (NCT06097481)
- Testing
- Narrative Intervention for Chronic Illness-Heart Failure, Attention Control
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Chronic Kidney Diseases, Heart Failure
Patient Education Video to Reduce OTC NSAIDs
The goal of this study is to assess the efficacy of a brief 3 to 5-minute educational video on influencing intent to change behavior regarding potentially harmful over-the-counter (OTC) NSAID use in adults with chronic kidney…
- Conditions
- Chronic Kidney Diseases, Heart Failure, Hypertension
- Trial name
- NCT06575205
- Testing
- Educational video
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- Carilion Clinic
Heart Failure, Chronic Heart Failure
Relationships and Differences Analysis in Heart Failure
This study characterizes heart failure patients who attended the University Hospital Würzburg. The primary aim is a better understanding of the relationships and differences between the subgroups HFrEF (EF < 40%), HFmrEF (EF…
- Conditions
- Heart Failure, Chronic Heart Failure, Chronic Heart Disease
- Trial name
- REDEAL-HF (NCT03966729)
- Testing
- Time (outcome)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- Wuerzburg University Hospital
Chronic Illness, NYHA Class II-IV Heart Failure
Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF)
Using the MOST framework, factorial pilot design, and an iterative, community-based process, the purpose of this study is to pilot test to further develop and refine a palliative care (PC) intervention addressing pain of Black…
- Trial name
- ADAPT HF (NCT06270875)
- Testing
- ADAPT HF
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham