Clinical trials: Heart Failure, completed
Rosuvastatin, Heart Failure
Dutch Sub Study: Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA). PET Sub Study
At one site, patients participating in the Corona main study are asked to participate in the PET-substudy. Before and 6 months after study medication is started a Positron Emission Tomography (PET-scan) is performed to study the…
- Conditions
- Rosuvastatin, Heart Failure, Positron Emission Tomography (PET)
- Trial name
- NCT00228514
- Testing
- Rosuvastatin, Positron emission tomography
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Congestive Heart Failure
Blood Volume and Hemodynamic Analysis in Patients With Chronic Heart Failure
The primary hypothesis is that patients with HFREF (heart failure with reduced ejection fraction) will demonstrate a markedly expanded intravascular volume which will correlate with elevated right heart hemodynamics and increased…
- Trial name
- NCT02120014
- Testing
- blood volume measurement, venous plethysmography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Heart Failure, Tachyarrhythmia
BIO|MASTER.Ilivia Family / Plexa
Post-Market Clinical Follow-up of the new Ilivia ICD Family and the new Plexa right ventricular lead to fulfill requirements by the notified body and to support regulatory approval outside of the CE region
- Trial name
- NCT02774616
- Testing
- Ilivia ICD Family, Plexa ICD lead
- Where
- 25 sites in Australia, Austria and 8 more
- Volunteers
- 292 people
- Sponsor
- Biotronik SE & Co. KG
Heart Failure
Left Ventricular Synchronous Versus Sequential MultiSpot Pacing for Cardiac Resynchronization Therapy (CRT)
The SYNSEQ study intends to assess the positive left ventricular dP/dt max achieved by MultiSpot LV pacing (either simultaneously or sequentially) in comparison to the response achieved by the current (standard) BiV pacing…
- Trial name
- SYNSEQ (NCT02914457)
- Testing
- Electrophysiological Study
- Where
- 7 sites in Poland, Slovakia and 3 more
- Volunteers
- 31 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Sinus Node Dysfunction, Heart Block AV
The Fluoroless-CSP Trial Using Electroanatomic Mapping
The goal of this study is to assess the feasibility, accuracy and safety of performing fluoroless (or low fluoro) conduction system pacing utilizing electro-anatomic mapping (EAM) with the CARTO 3 mapping system (Biosense Webster…
- Conditions
- Sinus Node Dysfunction, Heart Block AV, LBBB, Heart Failure, Systolic
- Trial name
- NCT03903107
- Testing
- Conventional fluoroscopy guided Conduction System Pacing(CSP), Electroanatomic Mapping (Fluoroless) guided Conduction System Pacing(CSP)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rush University Medical Center
Heart Failure
BioTechCOACH-ForALL: Development of Mental and Physical Exercise Systems, Clinical Recording, Supervisory Analytical Large-scale Data and Virtual Guidance of Vulnerable Population Groups
This would be a single center, parallel, two group randomized controlled pilot study that is designed to assess the feasibility and efficacy of the Virtual Coach Program in elderly patients with heart failure.
- Trial name
- NCT03877328
- Testing
- BiotechCoachForAll
- Where
- 2 sites in Greece
- Volunteers
- 13 people
- Sponsor
- Aristotle University Of Thessaloniki
Pulmonary Hypertension, Diastolic Heart Failure
Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure
Prevalence of heart failure (HF) with left ventricular (LV) diastolic dysfunction and preserved ejection fraction (EF) (HFpEF) is increasing.
- Trial name
- NCT01156636
- Testing
- Sildenafil
- Volunteers
- 44 people
- Sponsor
- University of Milan
Heart Failure
Effects of Low-frequency Electrical Stimulation in Patients With Advanced HF
The purpose of this study is to verify the effects of low frequency functional electrical stimulation in heart failure patients hospitalized for treatment of the syndrome.
- Trial name
- NCT01886430
- Testing
- Functional electrical stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure, Tachycardia
Safety and Efficacy Study of RENEWAL 4 AVT
The purpose of this study is to assess the safety and effectiveness of the CONTAK RENEWAL 4 AVT device.
- Conditions
- Heart Failure, Tachycardia, Atrial Fibrillation, Atrial Flutter
- Trial name
- NCT00180336
- Testing
- CRT-D
- Where
- Germany
- Volunteers
- 170 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Diastolic
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs…
- Trial name
- NCT04068844
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease, Bypass Complication
Early Silent Graft Failure in Off-pump Coronary Artery Bypass Grafting: A Computed Tomography Analysis
Aortocoronary bypass surgery is one of the most common operations in the western world. The goal of the surgeon is to perform a complete revascularization of the coronary arteries with the best, available bypass material.
- Conditions
- Coronary Artery Disease, Bypass Complication, Graft Failure
- Trial name
- NCT03657199
- Testing
- Cardiac computed tomography
- Volunteers
- 192 people
- Sponsor
- Triemli Hospital
Heart Failure, Decompensated Heart Failure
Use of Point-of-Care Ultrasound (POCUS) to Reduce Hospital Length of Stay in Patients With Heart Failure ( POCUSHF )
This study will evaluate whether using bedside ultrasound (also called Point-of-Care Ultrasound or POCUS) can help improve the care of hospitalized patients with decompensated heart failure.
- Conditions
- Heart Failure, Decompensated Heart Failure, Hospital Length of Stay
- Trial name
- POCUSHF (NCT06965712)
- Testing
- Point-of-Care Ultrasound (POCUS)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Florida International University
Myocardial Infarction, Heart Failure
Study of Oral PG-116800 Following a Heart Attack
The main purpose of the study is to test whether a possible new drug (called PG-116800) can prevent some of the damage to heart muscle in patients who have had a heart attack.
- Conditions
- Myocardial Infarction, Heart Failure, Heart Enlargement
- Trial name
- NCT00067236
- Testing
- PG-116800 (given as PG-530742)
- Where
- 52 sites in United States, Canada and 1 more
- Volunteers
- 253 people
- Sponsor
- Procter and Gamble
Congestive Heart Failure, Cardiac Resynchronization Therapy
Quartet™ Bad Oeynhausen Trial
Primary objective of this study is to evaluate whether the use of a quadripolar left ventricular (LV) electrode compared to a standard bipolar LV electrode leads to lower non-responder rates in patients undergoing cardiac…
- Trial name
- QUOTA (NCT01850264)
- Testing
- Application of quadripolar / bipolar LV electrodes
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure
The Effects of a High Fat and Low Carbohydrate Diet on Clinical Status in Patients With Heart Failure
The aim of the present study was to evaluate the effects of a high fat, low carbohydrate (CHO) diet on clinical status during 60 days of follow-up in patients with stable heart failure (HF).
- Trial name
- NCT02150798
- Testing
- High fat and low carbohydrate diet, Control diet
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Heart Failure, Heart Failure With Reduced Ejection Fraction
Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure
This is a feasibility study using a cross-over design to implement and compare a best practice alert (BPA) with an automated in-basket message to inform providers when a patient with heart failure and reduced ejection fraction…
- Trial name
- BETTER CARE-HF (NCT05077293)
- Testing
- Best Practice Alert (BPA), In-Basket Message
- Where
- United States
- Volunteers
- 596 people
- Sponsor
- NYU Langone Health
Systolic Heart Failure, Ventricular Premature Complexes
Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure.
- Conditions
- Systolic Heart Failure, Ventricular Premature Complexes, Ventricular Tachycardia, Cardiac Resynchronization Therapy
- Trial name
- NCT04065893
- Testing
- Catheter ablation of ventricular arrhythmia, Intensified medical therapy
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Köln
Heart Failure
Monitor Patients With Acute Heart Failure
This is a prospective, multi-center, non-randomized study to evaluate performance of an external monitor for heart failure patients
- Trial name
- ACUTE (NCT00919828)
- Testing
- Avivo System
- Volunteers
- 60 people
- Sponsor
- Corventis, Inc.
Atrial Fibrillation
Atrial Fibrillation (AF) Clinic to Improve the Treatment of Patients With Atrial Fibrillation.
Randomized controlled trial comparing specialized AF Clinic with 'care as usual' Hypothesis: treatment of AF patients in the AF-Clinic by a nurse, specialised in AF, using guideline-based dedicated software, under supervision of…
- Trial name
- AFClinic (NCT00753259)
- Testing
- AF Clinic, Care as Usual
- Where
- 2 sites in Netherlands
- Volunteers
- 712 people
- Sponsor
- Maastricht University Medical Center
Heart Failure, Branch Block, Bundle
DANISH-CRT - Does Electric Targeted LV Lead Positioning Improve Outcome in Patients With Heart Failure and Prolonged QRS
Heart failure is a leading cause of morbidity and mortality. Cardiac resynchronization therapy (CRT) is a well-established treatment for patients with symptomatic heart failure in spite of optimised medical treatment (OMT)…
- Trial name
- NCT03280862
- Testing
- Implantation of a Cardiac Resynchronisation Therapy (CRT) pacing device with or without Implanted Cardioverter Defibrillator
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Aarhus University Hospital
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