Clinical trials: Heart Failure，Congestive
Cancer Therapy-Related Cardiac Dysfunction, Heart Failure
Risk Stratification of Cancer Therapy-Related Cardiac Dysfunction Using AI-Enhanced Electrocardiography
This study investigates the use of AI-enhanced electrocardiogram (ECG) for risk stratification of cancer therapy-related cardiac dysfunction (CTRCD) before the initiation of cancer therapy.
- Conditions
- Cancer Therapy-Related Cardiac Dysfunction, Heart Failure, Left Ventricular Dysfunction
- Trial name
- NCT07515859
- Testing
- No intervention (retrospective observational study)
- Where
- South Korea
- Volunteers
- 31,486 people
- Sponsor
- Yonsei University
Heart Failure With Reduced Ejection Fraction
HF Patients With LVADs Being Treated With SGLT2i
The main purpose of this study is to observe outcomes of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in heart failure (HF) patients with left ventricular assist devices (LVAD).
- Trial name
- NCT05278962
- Testing
- SGLT2i, No SGLT2i
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Acute Heart Failure, Acute Renal Failure
Recombinant BNP on Heart and Renal Function in Acute Heart Failure
The purpose of this study is to evaluate the efficacy and safety of recombinant human B-type natriuretic peptide (rhBNP) on heart and renal function in patients with acute decompensated heart failure (ADHF) and acute renal injury…
- Trial name
- NCT01625403
- Testing
- rhBNP, standard of care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Patient Readmission, Pulmonary Disease, Chronic Obstructive
UM CRMC RecuR Score Pilot
This study will look to implement a plan for enhanced transitional care for patients at high risk of unplanned hospital readmission in hopes of reducing their risk for readmission in the first 30 days post discharge from an…
- Conditions
- Patient Readmission, Pulmonary Disease, Chronic Obstructive, Heart Failure, Diabetes Mellitus Poor Control
- Trial name
- NCT05765903
- Testing
- Standard of Care, Enhanced Care
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Heart Failure, Heart Failure Preserved Ejection Fraction
Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with preserved ejection fraction
- Conditions
- Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
- Trial name
- Cycle-2-PEF (NCT06215586)
- Testing
- Tovinontrine (CRD-750)
- Where
- 84 sites in United States, Australia and 13 more
- Volunteers
- 303 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.
HFpEF
Muscle Blood Flow Regulation in HFpEF
Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System.
- Trial name
- NCT05115890
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Adult Congenital Heart Disease
Real-World Data on the Effects of Cardiac Resynchronization Therapy in Adult Patients With Congenital Heart Disease
This study aims to evaluate the real-world effects of cardiac resynchronization therapy (CRT) in adult patients with congenital heart disease (ACHD).
- Trial name
- RECORD-CHD (NCT06969924)
- Testing
- Cardiac resynchronization therapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Heart Failure, Cognition Disorders
Cognitive Problems in Veterans With Heart Failure
We assessed the prevalence of cognitive/memory problems in veteran patients with heart failure, and evaluated its relationship to medication compliance.
- Trial name
- NCT01049308
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Heart Failure, Cardiomyopathy
Nebulized Inhaled Milrinone in a Hospitalized Advanced Heart Failure Population
Patients with end stage heart failure have significant symptoms (including fatigue and shortness of breath) which prevent them from being able to perform most activities of daily living.
- Trial name
- iMilrinone (NCT02077010)
- Testing
- Inhaled nebulized milrinone
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Heart Failure, Iron Deficiency
Iron in Congestive Heart Failure
The hypothesis to be tested is whether treatment with intravenous iron (ferric carboxymaltose) will improve left-ventricular ejection fraction in patients with heart failure and iron deficiency as determined by cardiac magnetic…
- Conditions
- Heart Failure, Iron Deficiency, Anemia
- Trial name
- iCHF (NCT01837082)
- Testing
- ferric carboxymaltose
- Where
- 3 sites in Germany
- Volunteers
- 18 people
- Sponsor
- University of Ulm
Heart Failure
Na+ Channel mRNA Regulation in Heart Failure
Human heart failure (HF) has been associated with reduced cardiac sodium channel current and other electrical remodeling. Recently, the investigators have shown that downregulation of cardiac Na+ channels (SCN5A) can contribute…
- Trial name
- NCT03313882
- Testing
- no intervention is involved
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Chronic Heart Failure With Reduced Ejection Fraction
Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction
The purpose of this study was to collect safety and tolerability data on LCZ696 in eligible PARADIGM-HF patients who received open-label investigational drug.
- Trial name
- NCT02226120
- Testing
- LCZ696
- Where
- 394 sites in United States, Argentina and 39 more
- Volunteers
- 1,980 people
- Sponsor
- Novartis Pharmaceuticals
Acute Decompensated Heart Failure
Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy
The purpose of this study is to determine whether Nesiritide is more effective than nitroglycerin in modifying inflammatory and neurohormonal biomarkers without renal toxicity when proper infusion duration is administered.
- Trial name
- ABC-HFT (NCT00842023)
- Testing
- Nesiritide, Nitroglycerin
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Western University of Health Sciences
Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure
Positive Care Effect of the Digital Health Assistant ADELE Blood Pressure for Hypertension Patients
High blood pressure (hypertension) can cause damage to vital organs such as the heart, kidneys, eyes, brain and blood vessels. The risk of developing high blood pressure increases with age.
- Conditions
- Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure, Hypertensive Heart Disease Without (Congestive) Heart Failure, Other Secondary Hypertension
- Trial name
- A0007 (NCT06663280)
- Testing
- Digital health assistant ADELE
- Where
- 2 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Alma Phil Gmbh
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
Telemonitoring of HFrEF Patients
The aim of this study is to find out whether remote health monitoring can help people with chronic heart failure. For 3 months, some patients use a SiDLY CARE PRO electronic wristband.
- Trial name
- NCT07835490
- Testing
- Telemonitoring wristband
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Heart Failure, Congestive, Metabolic Syndrome X
The Effect of Diet and Exercise in Heart Failure
A growing number of people in this country are overweight or obese. This is concerning as increasing weight has been shown to increase the risk of developing heart failure.
- Conditions
- Heart Failure, Congestive, Metabolic Syndrome X, Obesity
- Trial name
- LIMIT-HF (NCT00297154)
- Testing
- Lifestyle Modification (diet, exercise, and behavior)
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive
Effect of Positive Airway Pressure Therapy on Hospitalization and Mortality in SDB Patients With Comorbid Chronic Obstructive Pulmonary Disease (COPD) or/and Heart Failure (HF)
The aim of the study is to test the hypothesis that treatment of sleep disordered breathing (SDB) in patients with comorbid chronic obstructive pulmonary disease (COPD) and/or heart failure (HF) with positive airway pressure…
- Conditions
- Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive, Heart Failure
- Trial name
- NCT02923505
- Testing
- polygraphy or polysomnography
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 383 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Heart Failure
CT Guided WiSE-CRT
This feasibility study will use CT scanning to identify the optimal location for placement of the WiSE-CRT system.
- Trial name
- NCT03495505
- Testing
- WiSE-CRT
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Heart Failure
Rapid Assessment of Bedside BNP In Treatment of Heart Failure (RABBIT)
To determine the clinical utility of using the Triage® BNP Test to guide therapy in outpatients with heart failure
- Trial name
- NCT00206856
- Testing
- Triage® B-Type Natriuretic Peptide (BNP) Test
- Where
- 29 sites in United States
- Volunteers
- 720 people
- Sponsor
- Abbott RDx Cardiometabolic
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