Clinical trials: Heart Failure, Systolic
Heart Failure and Reduced Ejection Fraction, NYHA Class III Heart Failure
Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure
The purpose of this prospective, multi-center, propensity-matched coverage with evidence development (CED) study is to assess the impact of cardiac contractility modulation (CCM) on mortality and heart failure hospitalizations in…
- Trial name
- BRIGHTEN-HF (NCT07209098)
- Testing
- Cardiac Contractility Modulation (CCM)
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- Impulse Dynamics
Heart Failure
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries.
- Trial name
- BRITISH (NCT05568069)
- Testing
- Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD)
- Where
- 47 sites in United Kingdom
- Volunteers
- 2,504 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Heart Failure, Congestive
ACCLAIM - Advanced Chronic Heart Failure CLinical Assessment of Immune Modulation Therapy
The purpose of this study is to test the safety and efficacy of the Celacade™ system in reducing the risk of mortality and cardiovascular hospitalizations in patients with chronic systolic heart failure.
- Trial name
- NCT00111969
- Testing
- Celacade™ system
- Volunteers
- 2,016 people
- Sponsor
- Vasogen
Heart Disease, Heart Failure
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
Heart failure (HF) is a global public health issue that affects more than 63 million people worldwide. The clinical and economic burden of HF on health care systems is substantial.
- Conditions
- Heart Disease, Heart Failure, Cardiovascular Disease, Heart Failure, Systolic
- Trial name
- PHRASE-HF (NCT06675552)
- Where
- 6 sites in Germany
- Volunteers
- 338 people
- Sponsor
- AstraZeneca
Congestive Heart Failure, Left Bundle Branch Block
MIRACLE EF Clinical Study
This study is looking at whether the electrical treatment provided by a special type of pacemaker called a Cardiac Resynchronization Therapy (CRT) pacemaker may keep a patient's heart failure from getting worse.
- Conditions
- Congestive Heart Failure, Left Bundle Branch Block, Systolic Heart Failure
- Trial name
- MIRACLE EF (NCT01735916)
- Testing
- CRT-P Implant, CRT-P OFF
- Where
- 73 sites in United States, India and 3 more
- Volunteers
- 44 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Prospective Study of the BioVentrix PliCath HF™ System for the Treatment of Ischemic Cardiomyopathy
The purpose of the study is to determine the safety, and feasibility of a device, which enables LV volume and radius reduction through scar exclusion in patients whose systolic HF is due to ischemic cardiomyopathy.
- Trial name
- CONFIGURE-HF (NCT01568138)
- Testing
- PliCath HF System
- Where
- 4 sites in Latvia, Lithuania and 2 more
- Volunteers
- 26 people
- Sponsor
- BioVentrix
Heart Failure
Open-label Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HF
The purpose of this study was to evaluate long-term safety and tolerability and to provide post-trial access to sacubitril/valsartan to eligible participants who successfully completed CLCZ696B2319 (PANORAMA-HF) core study Part 2…
- Trial name
- NCT03785405
- Testing
- sacubitril/valsartan
- Where
- 79 sites in United States, Argentina and 25 more
- Volunteers
- 216 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Dilated Cardiomyopathy
Danish ICD Study in Patients With Dilated Cardiomyopathy
The primary objective of this study is to determine the efficacy of ICD therapy compared with control on the endpoint of death from any cause in patients with heart failure of non-ischemic oetiology.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Reduced LVEF
- Trial name
- DANISH (NCT00542945)
- Testing
- ICD, Optimal medical treatment
- Where
- Denmark
- Volunteers
- 1,116 people
- Sponsor
- Danish Study Group
Symptomatic Congestive Heart Failure
The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF
The goal of this observational cohort study, which is both retrospective and prospective, is to evaluate the long-term clinical and instrumental response to Cardiac Contractility Modulation (CCM) treatment in adult subjects…
- Trial name
- PREDICT-CCM (NCT06973902)
- Testing
- Cardiac Contractility Modulation (CCM) implant
- Where
- 13 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Quovadis Associazione
Systolic Heart Failure
Effect of Nitrate-rich Beetroot Juice on Exercise Performance in Heart Failure Patients
Nitrate-rich beetroot juice supplementation has demonstrated reduced oxygen consumption and submaximal exercise performance in healthy adults.
- Trial name
- NCT02223403
- Testing
- nitrate-rich beetroot juice, nitrate-deplete beetroot juice
- Volunteers
- 12 people
- Sponsor
- Brooke Army Medical Center
Congestive Heart Failure, Systolic Dysfunction
Effect of Post Discharge Follow-up on Readmission Rates for Congestive Heart Failure Patients
The purpose of this study is to test the hypothesis that a comprehensive post-discharge disease management system is more effective in reducing the readmission rate for heart failure patients compared to standard care.
- Trial name
- NCT01529463
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Trinity Health Of New England
Atrial Fibrillation, Heart Failure
Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation
Rationale: Atrial fibrillation (AF) and heart failure (HF) can cause each other and sustain each other. Combined, the two diseases negatively influence each other's prognosis and lead to higher mortality.
- Conditions
- Atrial Fibrillation, Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic
- Trial name
- RACE-8-HF (NCT04342832)
- Testing
- Cryoballoon ablation
- Where
- 2 sites in Netherlands
- Volunteers
- 64 people
- Sponsor
- Maastricht University
Aortic Stenosis, Mitral Regurgitation
Evaluating Infrasonic Hemodynography
This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.
- Conditions
- Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic
- Trial name
- NCT04636892
- Testing
- MindMics earbud
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Scripps Health
Dyspnea
Systolic Time Intervals in the Diagnosis of Heart Failure in Emergency Departement
the gold standard for the diagnostic of acute heart failure is based on clinical, biological (BNP levels) and echocardiographic findings, but still in some cases, the diagnosis is difficult and requires further investigations.
- Trial name
- STA/AHF (NCT02161445)
- Testing
- the acoustic cardiographic parameters were calculated
- Where
- Tunisia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Heart Failure, Systolic
Acute Changes in Bioimpedance During Cardiac Resynchronization Therapy
This study aims at Optimizing measured parameters to reflect underlying pathology in dyssynchronous hearts. This is an experimental study in patients were bioimpedance measurements are performed during implantation.
- Trial name
- Impel (NCT03640000)
- Testing
- Impedance measurements in Cardiac Resynchronization therapy
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Heart Failure, Systolic, Ischemic Heart Disease Chronic
Growth Hormone in Ischemic Heart Failure
In a double-blind, placebo-controlled trial, we randomly assigned 37 patients (mean age 66 years; 95% male) with ischemic heart failure (HF) (ejection fraction (EF) < 40%) to a 9-month treatment with either recombinant human GH…
- Trial name
- NCT04420481
- Testing
- Somatropin
- Volunteers
- 37 people
- Sponsor
- Göteborg University
Heart Failure, Systolic, Pacemaker
Optimising Pacing for Contractility 2
The investigators have demonstrated that they can reliably identify an optimum heart rate range for contractility of the left ventricle in patients with chronic heart failure (CHF).
- Trial name
- OPT-cont 2 (NCT04201015)
- Testing
- Heart rate optimisation using force frequency data
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Leeds
Heart Failure, Systolic, Ketonemia
Effects of Ketones and Niacin in Heart Failure Patients
Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with reduced ejection fraction.
- Trial name
- KETO-COX (NCT04703361)
- Testing
- Niacin, Na-3-OHB
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
PASP
Effect of Sacubitril-Valsartan on Estimated Pulmonary Artery Systolic Pressure in Patients With Heart Failure With Reduced Ejection Fraction Heart Failure
Evaluate effect of Sacubitril-Valsartan on estimated pulmonary artery systolic pressure in patient with reduced ejection fraction heart failure
- Trial name
- NCT07814482
- Testing
- SACUBITRIL - VALSARTAN (formerly LCZ696, ENTRESTO®)
- Where
- Egypt
- Volunteers
- 59 people
- Sponsor
- Aswan University
Hypertension
Systolic Blood Pressure Intervention Trial
Elevated blood pressure (BP) is an important public health concern. It is highly prevalent, the prevalence may be increasing, and it is a risk factor for several adverse health outcomes, especially coronary heart disease, stroke…
- Trial name
- SPRINT (NCT01206062)
- Testing
- Intensive control of SBP, Standard control of SBP
- Where
- United States
- Volunteers
- 9,361 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)