Clinical trials: Heart Failure, Congestive
Congestive Heart Failure
Project Fluido: Fluid Watchers
The long-term goal of this research is to determine whether a psychoeducational intervention will support self-care behaviors in Hispanic patients with heart failure.
- Trial name
- NCT02083744
- Testing
- PsychoEducational Support, Usual Care
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Francisco
Heart Failure With Reduced Ejection Fraction
Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure
Heart Failure (HF) is a significant health concern, affecting around 1-2% of people in Western countries. The risk of developing HF during a lifetime is about 20%.
- Trial name
- KETO-CHF PET (NCT06398964)
- Testing
- 3-hydroxybutyrat
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Heart Failure
Management of Heart Failure in Italian Outpatients Clinics: Observational Study
OPTIMA-HF is an observational, cross-sectional, multicenter, real-life study conducted in two different clinical settings: HF outpatients' clinics of Italian University Hospitals and territorial Cardiology outpatients' services.
- Trial name
- OPTIMA-HF (NCT06287164)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- Federico II University
Heart Failure
iP2P Mentorship Program for Adolescent HF Patients
The iPeer2Peer (iP2P) program is an online peer support mentorship program that provides modelling and reinforcement by trained young adult peer mentors to adolescent mentees with the same condition.
- Trial name
- iP2P HF (NCT05709132)
- Testing
- iPeer2Peer Program
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- The Hospital for Sick Children
Bacterial Overgrowth Syndrome Small Bowel, Heart Failure with Preserved Ejection Fraction
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
Single-center, double-blind, randomized, controlled intervention study of the effect of correction of bacterial overgrowth syndrome in the small intestine (SIBO) on cardiac function in patients with heart failure with preserved…
- Trial name
- SIBO-HFpEF (NCT06652087)
- Testing
- Rifaximin, Standard HFpEF treatment
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Chronic Heart Failure, Obstructive Sleep Apnea
CPAP and Physiotherapy for Heart Failure and Sleep Apnea in the Elderly
This study evaluates whether adding physiotherapy (including herbal medicine, acupuncture, and Tuina massage) to standard continuous positive airway pressure (CPAP) therapy can provide superior benefits compared to CPAP alone for…
- Trial name
- NCT07061171
- Testing
- Continuous Positive Airway Pressure, Herbal Decoction, Acupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Weihua Peng
Heart Failure
The Study of Qishenyiqi Drop Pills in Improving the Prognosis of Heart Failure Patients
This is a multicenter, randomized, double-blind, placebo-controlled study including patients with ejection fraction decreased heart failure under standardized treatment, to evaluate QiShenYiQi (QSYQ) dropping pill's curative…
- Trial name
- NCT04028544
- Testing
- Qishenyiqi dropping pills
- Where
- China
- Volunteers
- 5,380 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pain, Heart Failure, Congestive
Help Veterans Experience Less Pain Study (HELP-Vets)
Our purpose is to evaluate the reliability and validity of the '5th vital sign' in everyday practice settings and to compare the relationship of pain to other symptoms and pain treatment in patients with cancer, CHF, and patients…
- Conditions
- Pain, Heart Failure, Congestive, Signs and Symptoms
- Trial name
- HELP-Vets (NCT00230932)
- Where
- United States
- Volunteers
- 654 people
- Sponsor
- US Department of Veterans Affairs
Heart Failure
A Clinical Study of HRS-7156 in Healthy Participants
The purpose of this Phase I study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-7156 in healthy participants.
- Trial name
- NCT07601087
- Testing
- HRS-7156
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Functional Mitral Regurgitation, Heart Failure
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).
- Conditions
- Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases
- Trial name
- NCT03142152
- Testing
- Carillon Mitral Contour System, Guideline Directed Heart Failure Medication
- Where
- 92 sites in United States, Canada and 6 more
- Volunteers
- 300 people
- Sponsor
- Cardiac Dimensions, Inc.
Pulmonary Hypertension
A Clinical Study of Sotatercept (MK-7962) in People With Combined Postcapillary and Precapillary Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (MK-7962-041)
Researchers are looking for other ways to treat people with combined postcapillary and precapillary pulmonary hypertension (CpcPH).
- Trial name
- CHORUS (NCT07839585)
- Testing
- Sotatercept
- Volunteers
- 352 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Heart Failure
Endocalyx for Heart Failure
The goal of this randomized, double-blind, placebo-controlled study is to assess whether the food supplement Endocalyx Pro reduces sodium and water excess in patients with chronic heart failure.
- Trial name
- GLYCO-HF (NCT05966415)
- Testing
- Endocalyx Pro
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Congestive Heart Failure
Empowering Elders Through Technology
Telehomecare is a technology that individuals use in their homes to communicate with health providers electronically. This technology can help them function at a higher level and avoid undesirable hospitalizations by making…
- Trial name
- NCT00261664
- Testing
- telehomecare
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Robert Wood Johnson Foundation
Heart Failure - NYHA II - IV
Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study
PEDAL-HF is a registry-based randomized prospective multicenter study. The investigators plan to include 1000 patients who were recently admitted with acute decompensated heart failure at five tertiary heart clinics in Germany.
- Trial name
- PEDAL-HF (NCT06656832)
- Testing
- Heart Failure network care
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University of Leipzig
Heart Failure With Preserved Ejection Fraction
Transthyretin Cardiac Amyloidosis in HFpEF
To estimate the prevalence of transthyretin cardiac amyloidosis (TTR-CA) among Heart Failure with Preserved Ejection Fraction (HFpEF) patients with increased LV wall thickness in Southeast Minnesota using 99mTc-PYP single-photon…
- Trial name
- NCT03414632
- Testing
- 99mTc-PYP
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Mayo Clinic
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
The aim of this study is to identify existing definitions and therapeutic approaches for acute right ventricular injury (RVI) in patients receiving extracorporeal membrane oxygenation (ECMO) for respiratory support.
- Conditions
- Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- NCT05948332
- Testing
- Delphi Rounds to generate consensus opinions among Experts
- Where
- United Arab Emirates
- Volunteers
- 52 people
- Sponsor
- Prashant Nasa
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Hypertrophic Cardiomyopathy
Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
A Study on the Efficacy, Safety, and Tolerability of Perhexiline maleate in Subjects with Hypertrophic Cardiomyopathy and Moderate-To-Severe Heart Failure
- Trial name
- NCT02431221
- Testing
- Perhexiline
- Sponsor
- Heart Metabolics Limited
Chronic Heart Failure (CHF)
Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
This study was a multi-center, randomized, double-blind, parallel group, active comparator trial designed to evaluate the overall effect of LCZ696 compared to valsartan on cognitive function as assessed by the CogState…
- Trial name
- PERSPECTIVE (NCT02884206)
- Testing
- LCZ696, Valsartan
- Where
- 135 sites in United States, Argentina and 18 more
- Volunteers
- 592 people
- Sponsor
- Novartis Pharmaceuticals
Mitral Valve Insufficiency, Atrial Fibrillation
Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation
A large left atrial (LA) volume, which represents chronic diastolic dysfunction, is associated with a poor outcome, regardless of systolic function.
- Conditions
- Mitral Valve Insufficiency, Atrial Fibrillation, Heart Failure
- Trial name
- NCT01172184
- Testing
- Cardiac catheterization
- Where
- Taiwan
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.