Clinical trials: Heart Block
Critical Stenosis of Aortic Valve
A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial)
We hypothesized that fimasartan, a new generation ARBs, would improve exercise capacity and decrease the rate of progression of AS by modifying hemodynamic factors and reducing adverse LV remodeling favorably in patients with…
- Trial name
- ALFA (NCT01589380)
- Testing
- Fimasartan
- Where
- 7 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Chronic Total Occlusion, Coronary Artery Disease
STENTYS Xposition S in the Treatment of Chronic Total Artery Occlusion
Intro: Chronic total occlusions (CTO) are the most severe coronary lesions. Negative distal vessel remodeling occurs in these lesions, leading to reduction of artery diameter.
- Trial name
- SXS-CTO (NCT03563989)
- Testing
- Implantation of Stent (PCI)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Valve Insufficiency, Aortic Valve Regurgitation
Trifecta™ Long Term Follow-Up (LTFU) Study
The Trifecta™ LTFU Study is a single-arm, multi-center, prospective, non-randomized, post-market study conducted in the United States and Canada to collect long-term safety and effectiveness data through 10 years after implant of…
- Conditions
- Aortic Valve Insufficiency, Aortic Valve Regurgitation, Aortic Valve Stenosis, Aortic Valve Incompetence
- Trial name
- NCT01593917
- Testing
- Trifecta™ Valve
- Where
- 11 sites in United States, Canada
- Volunteers
- 329 people
- Sponsor
- Abbott Medical Devices
Chronic Total Occlusion of Coronary Artery, Optical Coherence Tomography
Post-stenting Assessment of Reendothelialization With OFDI After CTO Procedure (PERFECTO)
The objective of PERFECTO is to assess the reendothelialization at 3 months after successfully CTO percutaneous intervention (PCI) with new generation drug eluting stent (DES) by OFDI analysis.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Optical Coherence Tomography, Ischemic Cardiomyopathy, Neointimal Hyperplasia
- Trial name
- PERFECTO (NCT03209843)
- Testing
- Percutaneous recanalization of chronic total occlusion
- Where
- 7 sites in France
- Volunteers
- 122 people
- Sponsor
- Poitiers University Hospital
Aortic Valve Stenosis, Artifical Intelligence
Smartphone Based Digital Screening for Aortic Valve Stenosis
Heart valve diseases are among the most serious cardiovascular conditions in older age. One of the most common forms is aortic valve stenosis, a narrowing of the valve opening between the left ventricle and the main artery.
- Trial name
- SMART-VALVE (NCT07284550)
- Testing
- Smartphone-based signal acquisition
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Coronary Artery Disease, Erector Spinae Plane Block
Effects of Erector Spinae Plane Block Method Used in Pain Management in Heart Surgery on Vascular Diameters
Off-pump coronary artery bypass grafting (OPCABG) is a bypass method performed on the working heart. Pain is a frequently seen side effect experienced following this surgery.
- Conditions
- Coronary Artery Disease, Erector Spinae Plane Block, Bypass Extremity Graft
- Trial name
- NCT04447560
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Koç University
Cardiac Disease, Surgery
Parasternal Block Combined With Rectus Sheath Block for Cardiac Surgery Under Sternotomy
The aim of this randomized controlled trial is to examine the effect of ultrasound guided bilateral Parasternal Nerve Block combined with rectus sheath block on preoperative analgesia, opioid consumption and respiratory function…
- Conditions
- Cardiac Disease, Surgery, Analgesia, Acute Pain
- Trial name
- PARARECTUS (NCT05764616)
- Testing
- PARASTERNAL BLOCK, LOCAL INFILTRATION OF DRAINAGE EXIT SITES, RECTUS SHEATH BLOCK
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Campus Bio-Medico University
Aortic Valve Stenosis
Randomized Comparison of Catheter-based Strategies for Interventional Access Site Closure During Transfemoral Transcatheter Aortic Valve Implantation
The aim of the study is to evaluate the clinical efficacy of 2 different vascular closure device (VCD) strategies during transfemoral transcatheter aortic valve implantation (TAVI).
- Trial name
- CHOICE-CLOSURE (NCT04459208)
- Testing
- Manta, ProGlide
- Where
- Germany
- Volunteers
- 516 people
- Sponsor
- Helios Health Institute GmbH
Aortic Valve Stenosis
Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling
Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population.
- Trial name
- AS-PROGRESSION (NCT03411317)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Rouen
Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD)
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating…
- Conditions
- Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD), Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- TAVR-CT (NCT07107568)
- Testing
- Standard Invasive Coronary Angiography, PCD-CT-Guided Diagnostic Strategy
- Where
- 2 sites in Austria
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Chronic Total Occlusion of Coronary Artery, Heart Failure
The NOrdic-Baltic Randomized Registry Study for Evaluation of PCI in Chronic Total Coronary Occlusion
Randomized registry for the study of CTO PCI as adjunction to optimal medical therapy.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Heart Failure, Angina Pectoris
- Trial name
- NOBLE-CTO (NCT03392415)
- Testing
- CTO PCI
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Leif Thuesen
Surgery Stress
The Effects of Erector Spinae Plane (ESP) Block on Surgery-related Stress Response in Cardiac Surgery With ERAS
Surgery-induced pain reveals its own metabolic and inflammatory responses, resulting in a further increase in noxious pathways that are already occurring.
- Trial name
- NCT04924335
- Testing
- Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Hypertension
Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women
This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched…
- Trial name
- NCT03432468
- Testing
- Valsartan 1, Valsartan 80 mg
- Volunteers
- 102 people
- Sponsor
- LanZhou University
Acute Myocardial Infarction, Unstable Angina
Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease
Preclinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound (DUS) transducer during an intravenous microbubble infusion (sonothrombolysis) can restore epicardial and microvascular…
- Trial name
- HUBBLE-I (NCT04732091)
- Testing
- Therapeutic ultrasound with 20 usec
- Where
- 2 sites in United States, Brazil
- Volunteers
- 540 people
- Sponsor
- University of Sao Paulo General Hospital
Aortic Valve Stenosis
A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification
The primary objective of the current study is to determine whether Ataciguat (HMR1766) slows progression of valve calcification in patients with moderate calcific aortic valve stenosis.
- Trial name
- CAVS (NCT02481258)
- Testing
- Ataciguat (HMR1766)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Aortic Valve Stenosis, TAVI
Exercise Training After Transcatheter Aortic Valve Implantation
In this prospective, controlled trial, patient after TAVI will be randomized to either exercise training or usual care group.
- Conditions
- Aortic Valve Stenosis, TAVI, Transcatheter Aortic Valve Implantation, Rehabilitation
- Trial name
- FitTAVI (NCT03966417)
- Testing
- Exercise training
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Aortic Stenosis, Aortic Regurgitation
Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disease
To compare changes in Left Ventricular Mass (LVM) depending on each blood pressure regulation between the intensive care group and the usual care group for patients with hypertension accompanied by aortic valve disease and…
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Hypertension, LVM
- Trial name
- NCT03666351
- Testing
- Amlodipine 5mg, Losartan, Losartan and Amlodipine
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Myocardial Infarction, Myocardial Ischemia
Time for a Paradigm Shift: STEMI/NSTEMI to OMI/NOMI ?
The current ST-segment elevation (STEMI)/non-STEMI treatment paradigm misses nearly one fourth of acute coronary occlusions (ACO) that needs immediately reperfusion.
- Trial name
- DIFOCCULT-2 (NCT05705102)
- Testing
- Coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people
- Sponsor
- Marmara University
Analgesia
NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
This clinical trial focuses on an elaborate, propensity-matched, non-inferiority comparison of NOL-guided Superficial Parasternal Intercostal Plane Block (SPIPB) and Erector Spinae Plane Block (ESPB) within the context of…
- Trial name
- NESP-II (NCT06070701)
- Testing
- Superficial Parasternal Block (SIPB), Erector Spinae Plane Block (ESPB), General anesthetic
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Sinus Node Disease, AV Block
Ingenio Device Algorithm Study
The purpose of the IVORY Study is to gather data to support global submissions/approvals for some models of the Ingenio device family.
- Conditions
- Sinus Node Disease, AV Block, Heart Failure
- Trial name
- IVORY (NCT01441583)
- Testing
- RAAT, RYTHMIQ
- Where
- 21 sites in Austria, Belgium and 10 more
- Volunteers
- 139 people
- Sponsor
- Boston Scientific Corporation