Clinical trials: Heart Arrest
Ventricular Fibrillation, Cardiac Arrest
SmartCPR Trial: An Analysis of a Waveform-Based Automated External Defibrillation (AED) Algorithm on Survival From Out-of-Hospital Ventricular Fibrillation
This study is designed to examine the impact of an available technology within an automated external defibrillator (AEDs) to improve survival following out-of-hospital cardiac arrest for patients presenting in ventricular…
- Trial name
- SmartCPR (NCT00535106)
- Testing
- Automated external defibrillator (Philips FR2+ AED), SmartCPR, Delayed defibrillation
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 900 people
- Sponsor
- New York City Fire Department
Cardiac Arrest, Heart Arrest
ECPR for Refractory Out-Of-Hospital Cardiac Arrest
In the U.S. alone, over 300,000 people per year have sudden out-of-hospital cardiac arrest (OHCA), and less than 1 out of 10 survive.
- Conditions
- Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest
- Trial name
- EROCA (NCT03065647)
- Testing
- Expedited Transport With Mechanical CPR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Out-Of-Hospital Cardiac Arrest
Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
The main objective of the trial is to find out if there is correlation between cerebral and skeletal muscle oxygenation values during cardiopulmonary resuscitation and if these values can predict return of spontaneous…
- Trial name
- NCT04058925
- Testing
- NIRS device
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- Miha Košir
Out of Hospital Cardiac Arrest, Cardiac Arrest
"The Effect of the Use of an Autotransfusion Device on Hemodynamic Parameters During Resuscitation".
The purpose of the research (pilot study) is to determine the impact of the use of the autotransfusion device on hemodynamic parameters during resuscitation.
- Trial name
- NCT06153160
- Testing
- HemaShock device
- Where
- 2 sites in Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Echocardiography, Transesophageal, Out-of-Hospital Cardiac Arrest
Prehospital TEE in Cardiac Arrest
This study shall investigate the feasibility of prehospital performed trans-esophageal echocardiography in out of hospital cardiac arrest.
- Trial name
- NCT05185596
- Testing
- Transesophageal Echocardiography
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Ventricular Tachycardia, Cardiovascular Diseases
Genetic Substudy of the Alternans Before Cardioverter Defibrillator (ABCD) Trial
The ABCD clinical study (ClinicalTrials.gov Identifier NCT00187291) was designed to determine if a T-Wave Alternans (TWA) test is equivalent to an Electrophysiology Study (EPS) in predicting life-threatening heart rhythms in…
- Conditions
- Ventricular Tachycardia, Cardiovascular Diseases, Arrythmia, CVD
- Trial name
- ABCD (NCT00583297)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- CardioDx
Cardiac Arrest
Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
The effectiveness of medications in cardiac arrest has been greatly debated and questioned. Historically intravenous adrenaline has been the drug of choice since 1906.
- Trial name
- PIVOT (NCT00358579)
- Testing
- Adrenaline, Vasopressin
- Where
- 4 sites in Singapore
- Volunteers
- 727 people
- Sponsor
- Singapore General Hospital
ICD Malfunction, Sudden Cardiac Death
S-ICD Electrode Registry
The subcutaneous implantable cardioverter defibrillator (S-ICD) is established in the prevention of sudden cardiac death, but recently a defect of the electrode's Sense-B component was reported in some patients.
- Trial name
- NCT05713708
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Köln
Cardiac Arrest
CT Perfusion (CTP) for Assessment of Poor Neurological Outcome in Comatose Cardiac Arrest Patients
ABSTRACT Brief Overview: Neurological assessment of comatose cardiac arrest patients (CCAP) is challenging because most of these patients are treated with sedatives and therapeutic hypothermia that prevent complete…
- Trial name
- CANCCAP (NCT04323020)
- Testing
- CT Perfusion
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Manitoba
Atrial Fibrillation, Supraventricular Arrhythmia
Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors
This study will enroll patients initiating Bruton Tyrosine Kinase (BTK) inhibitors without history of documented arrhythmia while on therapy using the Medtronic LINQ-2 insertable cardiac monitor (ILR).
- Conditions
- Atrial Fibrillation, Supraventricular Arrhythmia, Ventricular Arrhythmias and Cardiac Arrest, Chronic Lymphocytic Leukemia
- Trial name
- NCT05643235
- Testing
- Medtronic LINQ-2 Insertable Cardiac Monitor (ILR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Out-Of-Hospital Cardiac Arrest
AED-delivery Using Drones in Suspected OHCA
Time to defibrillation is the most important predictor of survival in cardiac arrest. Traditional emergency medical system response is often to slow.
- Trial name
- NCT04723368
- Testing
- Automated flying Drone carrying an Automated external defibrillator (AED)
- Where
- Sweden
- Volunteers
- 59 people
- Sponsor
- Karolinska Institutet
Hypoxia-Ischemia, Brain, Heart Arrest
buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest
RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.
- Conditions
- Hypoxia-Ischemia, Brain, Heart Arrest, Status Epilepticus, Refractory Status Epilepticus
- Trial name
- RESTORE (NCT05851391)
- Testing
- Burst Suppression EEG Target Intravenous Anesthesia, Seizure Suppression EEG Target Intravenous Anesthesia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Cardiovascular Diseases, Heart Diseases
Epidemiology of Cardiotoxicity in Children With Cancer
To provide a comprehensive analysis of risk factors for the development of clinical cardiotoxicities in over 6,000 children with cancer who had been treated on standardized protocols involving the use of anthracyclines alone or…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Congestive, Death, Sudden, Cardiac
- Trial name
- NCT00005418
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Arrest, Sudden Cardiac Arrest
Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America
The overall goal of this project is to design, develop, and pilot test an emergency healthcare drone delivery system suitable for rural communities that can deliver AEDs to out-of-hospital cardiac arrest (OHCA) locations more…
- Trial name
- RESTORe-CARE (NCT06229418)
- Testing
- DFR AED Pilot Program
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Pregnancy, Cardiac Arrest
Influence of the Method of Alleviation of Aorto-Caval Compression on the Trans-Hepatic Ultrasound-Assessed Inferior Vena Cava Diameter In Pregnant Patients
Cardiac arrest during pregnancy is rare but may result in poor maternal and fetal outcome. Because of its rare occurrence and ethical issues this topic is not very well studied and many questions pertaining to maternal…
- Trial name
- NCT01982513
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Arrest of Bone Development or Growth, Constitutional Delay of Growth and Puberty
YoUng Adolescents' behaViour, musculoskeletAl heAlth, Growth & Nutrition
More children will survive to adulthood today than at any other point in human history, as evidenced by the proportion of live births and absolute numbers.
- Conditions
- Arrest of Bone Development or Growth, Constitutional Delay of Growth and Puberty, Malnutrition, Child, Gestational Diabetes
- Trial name
- YUVAAN (NCT05603793)
- Testing
- Knowledge, Attitude & Practices
- Where
- India
- Volunteers
- 1,304 people, healthy volunteers welcome
- Sponsor
- Hirabai Cowasji Jehangir Medical Research Institute
Out-of-hospital Cardiac Arrest
Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest
ILCOR guidelines recommend Target Temperature Management (TTM) to between 32°C and 36°C after out-of-hospital cardiac arrest, based on low quality evidence.
- Trial name
- TTM-2 (NCT02908308)
- Testing
- Targeted temperature management to 33°C, Standard care with early treatment of fever
- Where
- 60 sites in United States, Australia and 12 more
- Volunteers
- 1,900 people
- Sponsor
- Helsingborgs Hospital
Circulatory Arrest
The Physiology of Circulatory Arrest in Humans
The purpose of this study is to better understand what happens in the brain during the dying process. This is a prospective observational study conducted at the end of life in the ICU at VGH.
- Trial name
- EVALUATE (NCT06130033)
- Testing
- Neuromonitoring
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Cardiac Arrest
Implementation of LUCAS 2 in Helicopter Rescue in South Tyrol
Cardiopulmonary resuscitation (CPR) is used to maintain adequate perfusion of vital organs in cardiac arrest patients and is fundamental for the neurological outcome and survival of these individuals.
- Trial name
- NCT01745926
- Testing
- MECHANICAL CHEST COMPRESSION
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Institute of Mountain Emergency Medicine
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC