Clinical trials: Healthy Participants, open to volunteers
Healthy Volunteer, Malaria
Positron Emission Tomography and Organ-Specific Changes in Participants Co-Enrolled in NIH Studies of Plasmodium Vivax Controlled Human Malaria Infection
Background: Malaria is a serious disease caused by parasites spread by mosquitoes. To better diagnose and treat malaria, researchers need to learn more about where the parasites go when they enter a person's body.
- Trial name
- NCT07859800
- Testing
- 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scan
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers
Study of Food Effects of VV119 Capsules in Chinese Healthy Volunteers
This study is a single-center, randomized, open label, 2×2 crossover design to assess the standard meal effects on PK of a single oral dose of VV119 in healthy adult subjects.
- Trial name
- NCT07240636
- Testing
- VV119
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Glaucoma, Open-Angle, Normal Tension Glaucoma
Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects.
- Conditions
- Glaucoma, Open-Angle, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT03870230
- Testing
- Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Dynamic Vessel Analyzer (DVA), Pattern Electroretinography (pERG)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy Volunteers
A Study to Evaluate the Pharmacokinetics and Safety of IN-M00007 and IN-R00007 in Healthy Adult Volunteers
This study aims to evaluate the Pharmacokinetic (PK) characteristics and safety after a single oral dose administration of IN-M00007 and IN-R00007 in healthy adult volunteers
- Trial name
- NCT07311811
- Testing
- IN-R00007, IN-M00007
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Healthy Subjects
Dermatological Safety and Skin Compatibility Evaluation of Test Products
Dermatological Safety and Skin Compatibility Evaluation of Test Product following Cosmetics Europe: Product Test Guidelines for Assessment of Human Skin Compatibility (Colipa Standard, 1997)
- Trial name
- NCT07195851
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Analgesia, Emergencies
Nebulized Fentanyl in Healthy Volunteers
Pain constitutes the predominant motive prompting individuals to seek emergency medical attention, accounting for 80% of admissions to emergency departments.
- Trial name
- AEROfen (NCT06281951)
- Testing
- Fentanyl - Inhalation by facial nebulization, Fentanyl - Nebulisation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Down Syndrome, Hemiparesis
Kinematic Analysis of Manual Dexterity
The following study aims to standardize the instrumented BBT for the objective evaluation of upper limb joint kinematics using MoCap on a population of healthy subjects between 4 and 18 years of age.
- Conditions
- Down Syndrome, Hemiparesis, Healthy Subjects
- Trial name
- SUPERFUN (NCT07875127)
- Testing
- Inertial Measurement Unit and Box and Block test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Healthy Adult
A Single Ascending Dose Study of DTI-117 Given Intramuscularly in Healthy Participants.
This is a single ascending dose, double-blind, placebo-controlled, randomized evaluation of the safety, tolerability, and pharmacokinetics of DTI-117 in healthy volunteers.
- Trial name
- NCT07882472
- Testing
- DTI-117
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dignify Therapeutics
Healthy Participants Study, Contact Lens Wear
Assessment of the Relationship of Soft Contact Lens Fit and Power (Fit & Lens pOwer Soft lenSes)
The purpose of this study is to evaluate whether altering the optical power (in dioptres) of a contact lens affects both vision and lens fit.
- Conditions
- Healthy Participants Study, Contact Lens Wear, Contact Lens Fit
- Trial name
- FLOSS (NCT06745375)
- Testing
- contact lens wear
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aston University
Inflammatory Bowel Disease (IBD)
Phase I Study of QLS1510 Tablets in Healthy Participants
This is a Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QLS1510 in Healthy participants
- Trial name
- NCT07760077
- Testing
- QLS1510 Tablets
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Qilu Pharmaceutical Research and Development Center LTD
Chronic Kidney Disease(CKD)
A Study to Evaluate the Safety, Tolerability and PK of SK-08
The trial is conducted in a single-center, randomized, double-blind, placebo-controlled, dose-increasing design. To evaluate the safety, tolerability, pharmacokinetics(PK) ,and pharmacodynamics (PD) characteristics of SK-08 in…
- Trial name
- SK-08 (NCT07021157)
- Testing
- SK-08
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Consun Pharmaceutical Group
Exercise, Blood Pressure
Effects of Lentil Protein Hydrolysate on Blood Pressure Control, Vascular Function and Exercise Performance
Examining the safety and tolerability of Lentil Protein Hydrolysate in healthy males and females whilst exploring the effects of a dose range on blood pressure control and vascular function and exercise performance
- Conditions
- Exercise, Blood Pressure, Vasodilation, Vascular Function in Healthy Volunteers
- Trial name
- NCT06894875
- Testing
- Lentil protein hydrolysate
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Healthy Volunteer
A Study Testing the Safety and Effects of FB102 in Healthy Volunteers
The purpose of this Phase 1 trial is to evaluate the safety and effects of FB-102 in healthy volunteers following single and multiple doses.
- Trial name
- NCT07623057
- Testing
- FB102 Single dose - Part A, FB102 Multiple doses - Part B, FB102 Multiple doses - Part C
- Where
- 2 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Forte Biosciences, Inc.
Leukocyte Disorders, Respiratory Tract Diseases
Collection of Lung Fluid and Tissue Samples for Research
This study will collect fluid and tissue specimens from the lungs and nose of healthy people and people with a history of lung infections.
- Conditions
- Leukocyte Disorders, Respiratory Tract Diseases, Bronchoscopy
- Trial name
- NCT00471250
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy Subjects, Healthy Participant Study
This is a Phase 1, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of BEAM-103 in Healthy Subjects
The purpose of this Phase I single ascending dose study is to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of BEAM-103 in healthy subjects between the ages of 18 and 55.
- Trial name
- NCT07304791
- Testing
- BEAM-103
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beam Therapeutics Inc.
Influenza
First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics
A randomized, double-blind, placebo-controlled Phase 1 study conducted at a single center with approximately 78 healthy adults aged 18-59 years.
- Trial name
- NCT07169318
- Testing
- VNT-101
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Menopause, Healthy Female Participants
A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System (TDS). The comparator drug is the Climara Pro® TDS.
- Trial name
- NCT07794150
- Testing
- Estradiol/Levonorgestrel Transdermal System
- Where
- 2 sites in United States, India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Menstrual Cycle, Physical Performance
Menstrual Cycle and Women's Performance
This study examines how different phases of the menstrual cycle are associated with selected performance and musculoskeletal parameters in physically active women aged 18-35 years.
- Conditions
- Menstrual Cycle, Physical Performance, Muscle Strength, Musculoskeletal System
- Trial name
- NCT07462286
- Testing
- Menstrual Cycle Tracking, Performance and Strength Testing, Musculoskeletal Assessment
- Where
- Czechia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Fentanyl Overdose, Fentanyl Poisoning
A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CS-1103 (1,000 mg), given by intravenous (IV) infusion in healthy participants in the presence of a clinically relevant dose of…
- Trial name
- NCT07459166
- Testing
- Naloxone Hydrochloride, Fentanyl, Sterile Saline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Type 1 Diabetes Mellitus, Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY)
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
This study aims to understand the heart and blood sugar health benefits of using an adjunctive therapy to lower high insulin levels in people with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY), MODY2 Diabetes, Healthy Volunteer
- Trial name
- ACT T1D (NCT06609356)
- Testing
- Study Visit 1, Study Visit 2, Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center