Clinical trials: Healthcare-associated Pneumonia
Ventilator Associated Pneumonia
Efficacy of Two Intermittent Subglottic Secretion
The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease
- Trial name
- NCT03871985
- Testing
- Subglottic secretion lavage combined with aspiration, Subglottic secretion aspiration
- Volunteers
- 234 people
- Sponsor
- The First Hospital of Jilin University
Pneumonia, Ventilator-Associated
Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia
The TOP-MDRVAP trial will test whether inhaled tobramycin can safely prevent pneumonia caused by multidrug-resistant bacteria in adults who need a breathing machine. Tobramycin is an antibiotic.
- Trial name
- TOP-MDRVAP (NCT07856355)
- Testing
- Tobramycin inhalation solution
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ventilator-associated Pneumonia
Biomarker-based Exclusion of VAP for Improved Antibiotic Stewardship
Critically ill patients whose lungs are supported by breathing machines (ventilators) commonly develop a new lung infection, called ventilator-associated pneumonia (VAP).
- Trial name
- VAPRapid-2 (NCT01972425)
- Testing
- Biomarker-based diagnostic
- Where
- 19 sites in United Kingdom
- Volunteers
- 211 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Pneumonia Ventilator Associated
VAP Incidence and Adequation to SRLF 2017 Diagnostic Among an Intensive Care Medicine Service for the Period 2022 à 2024
The goal of this observational study is to to analyze respiratory samples performed in mechanically ventilated ICU patients and to assess whether the SRLF criteria for defining VAP were respected among patients admited to the…
- Trial name
- PAVM-RéaCHSF (NCT07181824)
- Testing
- Diagnostic tedst
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Sud Francilien
Pneumonia
Clinician Ability to Predict the Presence of Nosocomial Pneumonia Based on Bronchoscopic Findings
This study aims to determine whether interpretations of bronchoscopic results enable physicians to successfully predict the presence of pneumonia in traumatically injured patients.
- Trial name
- NCT01904305
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Severe Pneumonia, Community-acquired Pneumonia
Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patients
Ambroxol is a mucolytic containing an active N-desmethyl metabolite of bromhexine. It is approved by both the U.S. FDA and EMA to be marketed under several formulations including oral, nasal, oro-mucosal, rectal and intravenous…
- Conditions
- Severe Pneumonia, Community-acquired Pneumonia, Hospital-acquired Pneumonia, Critical Illness
- Trial name
- NCT05663905
- Testing
- Ambroxol Hydrochloride, Standard Therapy
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- National University of Malaysia
Ventilator Associated Pneumonia, Death
Futility of Exhaled Breath Condensate pH Measurements in Ventilated Patients in Intensive Care Unit (ICU)
Measurement of pH in Exhaled breath condensate has been mentioned as a robust variable from lung inflammation. It is non-invasive and reproducible.
- Trial name
- NCT01393431
- Where
- Argentina
- Volunteers
- 34 people
- Sponsor
- Universidad Nacional de Rosario
SARS-CoV-2, BCG
SARS-CoV-2/COVID-19 Infection Among Health Care Workers
The present study finds opportunities and justifications, taking into consideration that the nature of professional practice in health needs scientific evidence resulting from systematic and systemic studies to strengthen the…
- Conditions
- SARS-CoV-2, BCG, Health Care Worker, COVID-19
- Trial name
- NCT04826718
- Testing
- Questionaire
- Where
- Cabo Verde
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universidade de Cabo Verde
Community Acquired Pneumonia, Hospital Acquired Pneumonia
HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract Infections
HOME FIRST (Home Followed - up with Infection Respiratory Support Team) is an early supported discharge scheme. It will enable patients with lower respiratory tract infection (LRTI) to be provided with high quality safe…
- Conditions
- Community Acquired Pneumonia, Hospital Acquired Pneumonia, Lower Respiratory Tract Infection
- Trial name
- HOMEFIRST (NCT02454114)
- Testing
- HOMEFIRST, Standard Hospital Care
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Hypoxemia, Hypercapnia
Optimising Ventilatory Strategies by Using Positive Respiratory Integer Measurements
Background Intermittent Positive Pressure Ventilation is used during general anesthesia but can lead to serious complications. Respiratory parameter settings can be adjusted to minimize the detrimental effects of this…
- Conditions
- Hypoxemia, Hypercapnia, Ventilator Associated Pneumonia, Complication of Anesthesia
- Trial name
- OPTIMVSPRIME (NCT06298435)
- Testing
- Intermittent Positive pressure ventilation
- Where
- Netherlands
- Volunteers
- 20,000 people
- Sponsor
- University Medical Center Groningen
Complicated Intra-abdominal Infection, Complicated Urinary Tract Infection
A Study to Learn About the Study Medicine Zavicefta After it is Released Into the Markets in Korea
The purpose of this study is to learn about the safety and effectiveness of Zavicefta once released into the markets in Korea. This study is to learn about Zavicefta in patients with difficult types of infections in the abdomen…
- Conditions
- Complicated Intra-abdominal Infection, Complicated Urinary Tract Infection, Hospital-acquired Pneumonia
- Trial name
- NCT05733104
- Where
- South Korea
- Volunteers
- 600 people
- Sponsor
- Pfizer
Ventilator Associated Pneumonia
Toothbrushing and Ventilator-associated Pneumonia
The hypothesis is that adding the toothbrushing to the oral care with clorhexidine 0.12% could be reduce the incidence of ventilator-associated pneumonia due to that oral cavity may be an important reservoir of pathogens that…
- Trial name
- NCT01477099
- Testing
- Toothbrushing with a manual brush
- Where
- Spain
- Volunteers
- 436 people
- Sponsor
- Hospital Universitario de Canarias
Covid19, Health Care Associated Infection
Incidence of Infection and Mortality by COVID-19 in Specialists
In this current study the researchers aim to identify the total number of infections and deaths due to COVID-19 and distinguish which are the risk factors most related to COVID-19 infections and deaths in medical personnel in…
- Conditions
- Covid19, Health Care Associated Infection, Infection, Coronavirus, Death
- Trial name
- NCT04828148
- Testing
- Survey
- Where
- Mexico
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Ventilator Acquired Pneumonia, Aspiration
Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients
The purpose of this study is to evaluate the impact of an optimized suctioning procedure on the risk of endotracheal microaspiration, measured by tracheal to oropharyngeal ratio of amylase enzymatic activity.
- Trial name
- AMYLASPI (NCT01807884)
- Testing
- Optimized oral care, Routine oral care
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bordeaux
Hospital Acquired Pneumonia
Validity of Biological Material Sampling in Patients With Hospital-acquired Pneumonia
The main objective of project is to compare validity of sampling methods performed routinely (bronchial secretion, stomach content, oropharyngeal smear) for determination of etiological agent responsible for hospital-acquired…
- Trial name
- NCT03039998
- Volunteers
- 56 people
- Sponsor
- University Hospital Olomouc
Blood Stream Infections, Ventilator Associated Pneumonia
EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics
RAPID is an investigator initiated Phase 4, multinational, multicentre, open-label, randomised controlled superiority trial evaluating the clinical impact of rapid microbiological diagnostics combined with antimicrobial…
- Conditions
- Blood Stream Infections, Ventilator Associated Pneumonia, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- RAPID (NCT05979545)
- Testing
- Rapid Diagnostics
- Where
- 21 sites in India, Malaysia and 5 more
- Volunteers
- 1,526 people
- Sponsor
- National University of Singapore
Ventilator Associated Pneumonia, Corona Virus Infection
Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients
The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients.
- Trial name
- NCT04372576
- Testing
- Assessment of ventilator-associated pneumonia criteria
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Hospital-acquired Pneumonia, Ventilator Associated Pneumonia
HOspital NEtwork STudy - Preparation for a Randomized Evaluation of Anti-Pneumonia Strategies
Hospital Acquired and Ventilator Associated Pneumonia (HAP/VAP) pose a significant burden to patients admitted to the Intensive Care Unit (ICU).
- Trial name
- HONEST-PREPS (NCT05060718)
- Where
- 16 sites in Albania, Croatia and 5 more
- Volunteers
- 2,165 people
- Sponsor
- UMC Utrecht
Ventilator Acquired Pneumonia
Bronchial Colonization With Fungi and Late Respiratory Acquired Pneumonia
Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi…
- Trial name
- CBF et PAVMt (NCT01770015)
- Testing
- biological sampling, sampling blood, endotracheal aspiration
- Where
- 2 sites in France
- Volunteers
- 213 people
- Sponsor
- University Hospital, Grenoble