Clinical trials: Headache (Migraine)
Chronic Migraine
Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine
The purpose of this study is to evaluate the safety, tolerability, and changes in the number of migraine and headache days with repeated subcutaneous administration of IONIS-PKKRx (ISIS 546254) or placebo in subjects with chronic…
- Trial name
- NCT03108469
- Testing
- IONIS-PKKRx (ISIS 546254)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Smith, Timothy R., M.D.
Low Back Pain, Migraine
Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain
The purpose of this study is to evaluate the safety and tolerability of OraVescent fentanyl for the potential treatment of breakthrough pain episodes in patients who have chronic noncancer pain.
- Conditions
- Low Back Pain, Migraine, Diabetic Neuropathies, Osteoarthritis
- Trial name
- NCT00228605
- Testing
- OraVescent Fentanyl
- Where
- 38 sites in United States
- Volunteers
- 500 people
- Sponsor
- Cephalon
Cyclic Vomiting Syndrome
Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome
This is a multicenter, randomized, double-blind, parallel group, placebo-controlled, efficacy and safety study of adult outpatients diagnosed with CVS and experiencing recurring episodes of stereotypical vomiting.
- Trial name
- NCT04645953
- Testing
- 3mg AZ-010, 1mg AZ010
- Where
- 18 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Migraine Headache With Intractable Migraine
Ketamine for Refractory Chronic Migraine: a Pilot Study
Ketamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic…
- Trial name
- NCT03896256
- Testing
- ketamine infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Thomas Jefferson University
Migraine With or Without Aura
An Acute Migraine Factorial Study
The study consists of a screening visit, out-patient treatment of a moderate or severe migraine attack with a single dose of the study medication within 8 weeks, and End-of-Study Visit 2-7 days after dosing.
- Trial name
- ANODYNE-1 (NCT06245902)
- Testing
- Naltrexone and Acetaminophen, Naltrexone and Acetaminophen-High Dose, Naltrexone Alone (regular dose)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Allodynic Therapeutics, Inc
Migraine Without Aura
Functional MRI (fMRI) in CGRP Induced Migraine
In patients known with migraine without aura a migraine headache or migraine like headache will be induced by infusion of calcitonin gene related peptide (CGRP).
- Trial name
- NCT00363532
- Testing
- infusion of calcitonin gene related peptide (CGRP)
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Headache Center
Migraine
Mindfulness and Mechanisms of Pain Processing in Adults With Migraines
Although many adults with migraines use non-pharmacological treatment options, there is a lack of research on the use of many mind/body techniques specifically for headache.
- Trial name
- NCT02695498
- Testing
- Mindfulness Based Stress Reduction, Migraine/stress Education
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Wake Forest University Health Sciences
Migraine
Pain Control in Episodic and Chronic Migraine
The phenomenon of offset analgesia (OA) refers to a disproportionately large decrease in perceived pain following a slight reduction in the intensity of a noxious heat stimulus.
- Trial name
- NCT06599905
- Testing
- Episodic Migraine (EM), Chronic Migraine (CM)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Headache, Migraine
Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
Metoclopramide (Reglan) is a common agent used for relief of headaches in the emergency department (ED).In this study the investigators seek to explore another option for treatment of headaches in the ED, one that may be more…
- Trial name
- NCT02972502
- Testing
- Metoclopramide, Haloperidol, Normal Saline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- OhioHealth
Chronic Migraine Headache
Efficacy of Traditional Integrated Islamic Psychotherapy and Cognitive Behavioural Therapy for Migraine: A Randomized Controlled Trial
his randomized controlled trial aims to evaluate the efficacy of Cognitive Behavioral Therapy (CBT) and Traditional Integrated Islamic Psychotherapy (TIIP) as psychological interventions for individuals with chronic migraine.
- Trial name
- CBT TIIP (NCT07802912)
- Testing
- Cognitive Behavioral Therapy (CBT), Traditional Integrated Islamic Psychotherapy (TIIP), Medication Group
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- GIFT University
Migraine, Traumatic Brain Injury
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents
This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI).
- Conditions
- Migraine, Traumatic Brain Injury, Anomalous Health Incidents
- Trial name
- NCT07267819
- Testing
- Xeomin (incobotulinumtoxinA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Uniformed Services University of the Health Sciences
Migraine, Headache
Amitriptyline vs GON and SON Blocks in Migraine
Comparison of efficacy and safety of amitriptyline and nerve blocks
- Trial name
- NCT04750967
- Testing
- Lidocaine 1% Injectable Solution, Amitriptyline
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Migraine
Study of Pediatric Migraine: The Pediatric Migraine Registry
This is a multi-center registry that will prospectively collect regulatory compliant data from children and adolescents with migraine.
- Trial name
- NCT03742024
- Where
- 19 sites in United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Migraine, With or Without Aura
Safety and Efficacy Study in Adult Subjects With Acute Migraines
The purpose of this study is to compare the efficacy of BHV-3000 (rimegepant) versus placebo in subjects with Acute Migraines
- Trial name
- NCT03235479
- Testing
- Rimegepant
- Where
- 50 sites in United States
- Volunteers
- 1,485 people
- Sponsor
- Pfizer
Migraine
Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without Migraine
This study comprised two separate assessor-blinded randomized crossover experiments, one in participants with migraine and one in participants without migraine.
- Trial name
- NCT07143461
- Testing
- Prayer Condition, Reading Condition
- Where
- Brazil
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Migraine Headache, Episodic
A Non-Invasive Neuromodulation Device for Treatment of Migraine Headache
This is a randomized, blinded study designed to assess the efficacy of a portable, non-invasive neuromodulation system for the treatment of episodic migraine headaches.
- Trial name
- NCT01899040
- Testing
- neuromodulation for episodic migraine headache
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Scion NeuroStim
Migraine Without Aura, Migraine With Aura
Impact of a Nurse for Migraine Management: the IMPACT Project
Headache disorders are prevalent, disabling, under recognized, under diagnosed and under treated. Migraine has a prevalence of 10% in men and 25% in women in Canada.
- Conditions
- Migraine Without Aura, Migraine With Aura, Chronic Migraine
- Trial name
- IMPACT (NCT01804517)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Notre-Dame Hospital, Montreal, Quebec, Canada
Migraine
Efficacy and Safety of Eslicarbazepine Acetate as Preventive Therapy for Subjects With Migraine
This was a multinational, randomised, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety, and tolerability of multiple doses of ESL as prophylactic treatment in subjects with migraine with or…
- Trial name
- NCT01820559
- Testing
- ESL 1200 mg, ESL 800 mg
- Volunteers
- 452 people
- Sponsor
- Bial - Portela C S.A.
Migraine Headaches, Breathing Techniques
Effect of Breathing Techniques on Migraine Attacks and Severity
Background: Migraine is a very common neurobiological disorder caused by increased excitability of the Central Nervous System. It is among the causes of the highest morbidity worldwide.
- Trial name
- NCT05536635
- Testing
- breathing techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Dokuz Eylul University
Migraine
A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache
Subjects are scheduled to undergo a Greater Occipital Nerve Block (GONB) as treatment for your chronic daily headache (CDH). GONB has been used for many years in the treatment of headaches.
- Trial name
- NCT00203294
- Testing
- lidocaine, bupivicaine and saline, lidocaine plus bupivicaine plus triamcinolone (steroid)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Thomas Jefferson University
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