Clinical trials: Headache
Migraine
A Dual Intervention in Migraine Treatment: Tens and Exercise
The aim of this clinical trial was to investigate the effects of TENS and exercise training on pain and disability in women diagnosed with migraine.
- Trial name
- NCT07125820
- Testing
- Experimental Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Suleyman Demirel University
Headache
A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks
Greater occipital nerve (GON) injection is a commonly performed diagnostic and therapeutic procedure in headache patients. GON blocks have been shown to be effective in the treatment of a variety of headaches including occipital…
- Trial name
- NCT02655523
- Testing
- Triamcinolone, Dexamethasone, Normal Saline
- Where
- United States
- Sponsor
- Northwestern University
Headache Disorders, Headache
Can a Specific OMT Protocol Influence Patient Pain and Associated Analgesia Use for Primary Headache Disorders?
The purpose of this study is to see if osteopathic manipulation or light touch can reduce either or both frequency of headaches or use of pain medication.
- Conditions
- Headache Disorders, Headache, Analgesia, Opioid Use
- Trial name
- NCT06546462
- Testing
- Osteopathic Manipulative Treatment (OMT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York Institute of Technology
Migraine
Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)
The purpose of this study is to determine the receptor occupancy (RO) associated with telcagepant (MK-0974) administration based on displacement of [11C]MK-4232 from the CGRP receptors in the brain using PET.
- Trial name
- NCT01315847
- Testing
- telcagepant, [11C]MK-4232
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Migraine
Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention
The primary objective of the study was to evaluate the effect of erenumab compared to placebo on the change from baseline in monthly migraine days.
- Trial name
- STRIVE (NCT02456740)
- Testing
- Erenumab
- Where
- 129 sites in United States, Austria and 11 more
- Volunteers
- 955 people
- Sponsor
- Amgen
Headache, Migraine
Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache
Objective: To determine if lower paracervical intramuscular ropivacaine injection is an effective treatment for pediatric headache in an emergency department setting.
- Trial name
- NCT00680823
- Testing
- Ropivacaine, Normal saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Robert Hickey
Posttraumatic Headache
Hypersensitivity to Adrenomedullin in Post-Traumatic Headache
Adrenomedullin is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether adrenomedullin induces headache with migraine-like features in people with persistent post-traumatic headache (PTH)…
- Trial name
- NCT07059546
- Testing
- Adrenomedullin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Chronic Migraine, Headache
Mesotherapy in the Treatment of Chronic Migraine
Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin.
- Trial name
- NCT06118190
- Testing
- Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Headache
Evaluation of Headache and Childbirth in a Chronic Pain Population
Headache and backache are common symptoms following childbirth. The incidence of these symptoms have been shown to increase during the postpartum period between 5 to 12 months following delivery.
- Trial name
- NCT04632420
- Where
- United States
- Volunteers
- 1,112 people, healthy volunteers welcome
- Sponsor
- Stanford University
Migraine
Efficacy of Smartphone Based Digital Application in Improving Headache Related Parameters in Patients With Migraine
Migraine is a common headache disorder and affects 1 in 5 adults during their lifetime. It is a disorder which leads to significantly impaired quality of life, absence from work, loss of productivity in workplace and reduced…
- Trial name
- NCT04984720
- Testing
- Smartphone based digital application
- Where
- India
- Volunteers
- 403 people
- Sponsor
- All India Institute of Medical Sciences
Low Back Pain, Headache
A Randomized Controlled Trial of Best Approach to Care Compared to Diversified Chiropractic Adjustive Technique
There are a variety of treatment approaches used by the chiropractic profession. Some of these require forceful joint manipulation and some do not.
- Conditions
- Low Back Pain, Headache, Shoulder Pain
- Trial name
- NCT00163124
- Testing
- spinal manipulation & patient education/nutrition
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Parker College of Chiropractic
Migraine Disorders, Brain, rTMS Stimulation
Prospective Exploratory Study on rTMS for Migraine Under the Guidance of MEG
Using magnetoencephalography to locate and regulate targets in migraine patients, repeating transcranial magnetic stimulation to physically regulate targets, and evaluating the safety and effectiveness of this treatment method…
- Trial name
- NCT06796725
- Testing
- rTMS, Sibelium
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Migraine
Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine
There are still no reliable biomarkers for migraine; the diagnosis is based on symptomatology, and the pathogenesis remains largely a mystery.
- Trial name
- BioM (NCT07832032)
- Testing
- Rimegepant 75 MG
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Nordlandssykehuset HF
Migraine
Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT02196532
- Testing
- Device: Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Tension-Type Headache
HVLAT, Electric DN, Exercise Vs. Mobilization, STM, Exercise, TENS for Tension Type Headaches
The purpose of this research is to compare two different approaches for treating patients with tension-type headaches: thrust Manipulation, electric dry Needling and exercise Vs.
- Trial name
- NCT04609709
- Testing
- Thrust Manipulation, Electric Dry Needling and Exercise, Non-thrust Mobilization, Soft-Tissue Mobilization, Exercise and TENS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Alabama Physical Therapy & Acupuncture
Episodic Migraine Headache
Craniocervical Flexion Training for Reducing Migraine Headaches and Disability
Migraine, a leading cause of disability globally, necessitates effective interventions beyond pharmacotherapy due to the associated risks.
- Trial name
- NCT06751732
- Testing
- Craniocervical Flexion Training (CCFT), Diaphragm Respiratory Training, Cervical Mobilization and Traction
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Migraine
Metoclopramide for Migraine: A Dose Finding Study
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do not know the best dose to administer. This study compares three different doses of metoclorpamide.
- Trial name
- MDFS (NCT00682734)
- Testing
- metoclopramide, Diphenhydramine 25mg
- Where
- United States
- Volunteers
- 349 people
- Sponsor
- Montefiore Medical Center
Migraine
The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients
The aim of this study is to determine the effects of omega 3 fatty acid, curcumin and their combination or placebo for 2 months on the gene expression of COX-2, iNOS, TNF-α, IL-1β, IL-6, VCAM-1 and ICAM-1 in the peripheral blood…
- Trial name
- NCT02532023
- Testing
- omega 3 fatty acid, curcumin
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Migraine, Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain.
- Conditions
- Migraine, Pain, Nausea, Vomiting
- Trial name
- NCT03877718
- Testing
- Arm 1: CL-H1T, Arm 2: CL-H1T, Arm 3: Sumatriptan Succinate 100 mg capsule
- Where
- 3 sites in United States
- Volunteers
- 475 people
- Sponsor
- Charleston Laboratories, Inc