Clinical trials: Harmful Use
Tobacco; Use, Harmful
The Influence of Electronic and Traditional Cigarettes Smoking on Hemodynamic Parameters
It is intended to examine 50 healthy volunteers aged 18 - 60 years. 12-hour abstinence from tobacco smoke, alcohol or coffee before the experiment will be required.
- Trial name
- EPAPHemo (NCT03037775)
- Testing
- Baseline, e-cigarette without nicotine, e-cigarette with nicotine
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Tobacco Use, Oxidative Stress
Little Cigar Oxidants
Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 3 exposure groups.
- Trial name
- NCT06310187
- Testing
- High Oxidant Little Cigar, Low Oxidant Little Cigar, Usual Cigarette
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Insomnia, Alcohol; Harmful Use
Sleep as a Mechanism of Change in Alcohol Use
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
- Trial name
- ReTRAIN (NCT06286774)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Alcohol; Harmful Use, Sex, Unsafe
MI With Text Messaging to Reduce Sexual Risk and Hazardous Drinking Among MSM
This is a small pilot study to provide effect size estimates for a brief intervention designed to reduce hazardous drinking and sexual risk behavior among men who have sex with men.
- Trial name
- MI&TXT4MSM (NCT03755661)
- Testing
- MI&TXT4MSM
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alcohol Abuse, Alcohol Use Disorder
Skills-training for Reducing Risky Alcohol Use in App Form
This study evaluates the efficacy of a skills training web-based mobile phone application, Telecoach among individuals in the general population seeking help for their risky alcohol consumption on the Internet.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Alcohol Dependence
- Trial name
- NCT03696888
- Testing
- Telecoach, TeleCoach control
- Where
- Sweden
- Volunteers
- 678 people
- Sponsor
- Karolinska Institutet
Alcohol Consumption, Alcohol; Harmful Use
Patient Trajectories for Older Adults Admitted to Hospital for Alcohol-related Problems
Alcohol is contributing to many health problems and disorders, as well as accidents and social problems. Alcohol consumption has been on the rise the past 25 years, especially in Norway.
- Conditions
- Alcohol Consumption, Alcohol; Harmful Use, Health Risk Behaviors, Alcohol Dependence
- Trial name
- NCT04164940
- Testing
- Brief alcohol intervention
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Helse Stavanger HF
Heavy Drinking, Harmful; Use, Alcohol
A PPG Sensor-Based Feedback Intervention for Heavy Drinking Young Adults
Heavy alcohol use among young adults is a significant public health problem. Advances in technology may offer an innovative solution.
- Trial name
- NCT05090995
- Testing
- Behavioral Self-Management and Feedback, Behavioral Self-Management
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcoholic Liver Disease (ALD), Alcohol Use Disorder
Elastography-based Brief Alcohol Intervention in Hospitalized Individuals
Harmful alcohol use is a common cause of hospital admissions and the leading cause of liver cirrhosis. Timely detection of liver disease is crucial to prevent liver disease progression and reduce alcohol-related harms.
- Trial name
- PREDILECTION (NCT07637539)
- Testing
- Elastography-based brief alcohol intervention
- Where
- 8 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Alcohol; Harmful Use
Testing A Couple-based Program for Alcohol Risk Reduction in the National Guard
The purpose of this project is to develop and test indicated prevention intervention to harness support and health promoting endeavors to address use of alcohol to cope with reintegration challenges in Massachusetts National…
- Trial name
- GF_CARE (NCT03589508)
- Testing
- In-person sessions: ABCP_P, Video conference sessions: ABCP_T
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Abuse, Harmful Alcohol Use
Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment
Many people who have risky alcohol use or alcohol dependence do not seek help, often is due to concerns about potential consequences or feelings of shame.
- Conditions
- Alcohol Abuse, Harmful Alcohol Use, Hazardous Alcohol Use, Hazardous Drinking
- Trial name
- NCT06675812
- Testing
- Information intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use.
- Trial name
- VAT (NCT01750268)
- Testing
- Medical Management Counseling, Topiramate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Harmful; Use, Alcohol, Hazardous; Use, Alcohol
Primary Care Implementation Study to Scale up EIBI and Reduce Alcohol Related Negative Outcomes
The aim of this implementation study is to compare the effect of tailored training and support (T\&S) for general practioners with T\&S and alcohol community actions and the impact it has on early identification of hazardous and…
- Trial name
- PINO (NCT04398576)
- Testing
- Training and support, Community actions
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Alcohol Use Disorder, Alcohol-Related Injury
Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon
Brief Summary Alcohol use is a major contributor to injury burden in Cameroon, particularly among trauma patients presenting to emergency departments.
- Conditions
- Alcohol Use Disorder, Alcohol-Related Injury, Trauma
- Trial name
- NCT07677449
- Testing
- Cameroon-Adapted SBIRT, Usual Care
- Where
- Cameroon
- Volunteers
- 690 people
- Sponsor
- University of Buea
Substance Use
Impact of a Computer-Assisted SBIRT Program in an HIV Care Setting
The goal of this research is to assess the impact of the "screening, brief intervention, and referral to treatment" (SBIRT) intervention strategy for harmful substance use among HIV-positive people.
- Trial name
- SBIRT (NCT01300806)
- Volunteers
- 210 people
- Sponsor
- University of California, San Francisco
Alcohol Use, Underage, Harmful; Use, Alcohol
Efficacy of the Expectancy Challenge Alcohol Literacy Curriculum on Reducing College Student Alcohol Use and Harms
The current project uses a web-based program called the Expectancy Challenge Alcohol Literacy Curriculum (ECALC) to reduce alcohol use and associated harms among college students.
- Trial name
- ECALC (NCT05616247)
- Testing
- ECALC, ECALC Plus Weekly Boosters
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Burnout, Student, Alcohol; Harmful Use
Summative Assessment of the BurntOut 3D Simulation With Medical Students
Burnout is a common problem for medical students and is associated with stress-related health problems and also potentially affects the quality of care delivered to their patients.
- Conditions
- Burnout, Student, Alcohol; Harmful Use, Quality of Life, Depression
- Trial name
- NCT04494633
- Testing
- Clinical Encounters Medical School 3D Simulation
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Clinical Tools, Inc.
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI
The goal of the project is to improve the care of Veterans with mild traumatic brain injury (mTBI) and unhealthy alcohol use.
- Trial name
- NAC (NCT02791945)
- Testing
- Medical Management Counseling, N-acetylcysteine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Tobacco Use
Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches
The purpose of this study is to generate evidence regarding the extent of reduction in exposure to selected HPHCs in adult smokers switching to on!® NPs.
- Trial name
- NCT05664672
- Testing
- OTDN Product 1, OTDN Product 2, OTDN Product 3
- Where
- 3 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Opioid-use Disorder, Harmful; Use, Alcohol
Patient Driven Recovery With Nalmefene and Coaching
In collaboration with the First Pavlov State Medical University in St. Petersburg, Russia, we are proposing a pilot, open label, non-randomized clinical trial to evaluate the safety, feasibility, acceptability, and preliminary…
- Trial name
- NCT03279562
- Testing
- Nalmefene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University