Clinical trials: HIV Positive
HIV Infections, Mycobacterium Infections
Phase II Placebo Controlled Study of Thalidomide in Patients With Mycobacterial and HIV Infections
OBJECTIVES: I. Evaluate whether thalidomide modulates toxic host inflammatory responses in patients receiving antitubercular therapy. II.
- Conditions
- HIV Infections, Mycobacterium Infections, Tuberculosis
- Trial name
- NCT00004276
- Testing
- thalidomide
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
HIV-positive
Medico-social Description of Seniors Living With HIV, Associated With a Qualitative Survey on Their Care in the Paris Region Structures
This study is part of a national vision to fight against serophobia and support society towards more ethical and benevolent practices vis-à-vis aging and specific populations.
- Trial name
- VIAGE (NCT05135689)
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Gérond'if
HIV, Tuberculosis
EARNEST Rifabutin Pharmacokinetics (PK) Substudy
Background and study aims? Some of the drugs used to treat HIV (anti-retrovirals, or ARVs) can affect the blood levels of other drugs used to treat TB - called a "drug-drug interaction".
- Trial name
- NCT01663168
- Testing
- Rifabutin
- Where
- 9 sites in Uganda
- Volunteers
- 140 people
- Sponsor
- Justine Boles
HIV
Comparing Food and Cash Assistance for HIV-Positive Men and Women on Antiretroviral Therapy in Tanzania
The importance of good nutrition and food security among people living with HIV infection (PLHIV) is widely recognized. In resource-constrained settings, food insecurity is increasingly recognized as an important barrier to…
- Trial name
- NCT01957917
- Testing
- NAC (Nutritional Assessment and Counseling), Cash Transfer, Food Assistance
- Where
- 4 sites in Tanzania
- Volunteers
- 800 people
- Sponsor
- University of California, Berkeley
Tuberculosis, HIV
Interaction Between High Dose Rifampicine and Efavirenz in Pulmonary Tuberculosis and HIV Co-infection
We propose a first interaction study between efavirenz (EFV) and R20mg/Kg taking into consideration the absence of data about R induction at this dose.
- Trial name
- RIFAVIRENZ (NCT01986543)
- Testing
- drug administration
- Where
- Uganda
- Volunteers
- 105 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Tuberculosis, Hiv
A Pragmatic Randomised Study to Optimise Screening, Prevention and Care for Tuberculosis in Malawi
A pragmatic open, three-arm individually-randomised controlled trial and economic evaluation will be conducted in one primary health care centre in Blantyre, Malawi, where HIV and TB are major contributors to early mortality.
- Conditions
- Tuberculosis, Hiv, Tuberculosis, Pulmonary
- Trial name
- PROSPECT (NCT03519425)
- Testing
- Optimised HIV screening and linkage to care, Optimised tuberculosis screening and linkage to care
- Where
- Malawi
- Volunteers
- 1,455 people
- Sponsor
- Liverpool School of Tropical Medicine
Tuberculosis, HIV
Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children
Tuberculosis (TB) is a disease affecting the lungs that is caused by a germ spread by coughing. TB infection is currently diagnosed by a skin test that has limited accuracy.
- Trial name
- NCT00604617
- Testing
- Interferon-Gamma Release Assay, RT-23
- Where
- South Africa
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Syphilis
Evaluation of Enhanced Syphilis Screening Among HIV-positive Men
This study aims to enhance syphilis testing among HIV-positive men who have sex with men (MSM), so that more men will undergo testing, they will test more often, and more cases will be treated early.
- Trial name
- NCT02019043
- Testing
- Syphilis testing with routine HIV bloodwork
- Where
- 4 sites in Canada
- Volunteers
- 3,895 people
- Sponsor
- Unity Health Toronto
Syphilis, Sexually Transmitted Infections
Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex with Men (DaDHS)
Syphilis is a sexually transmitted infection (STI) disproportionately affecting gay, bisexual and other men who have sex with men (gbMSM), with the potential for significant sequelae - particularly in those who are Human…
- Trial name
- NCT02864550
- Testing
- Doxycycline
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- British Columbia Centre for Disease Control
HIV/AIDS
Improving Health Outcomes for Women Living With HIV
This study will develop and conduct a trans-specific peer navigation intervention in Brazil, which integrates the I-Care approach developed in South Africa with the Model of Gender Affirmation (GA), developed by the investigators…
- Trial name
- NCT03525340
- Testing
- Peer Navigation
- Where
- Brazil
- Volunteers
- 113 people
- Sponsor
- University of California, San Francisco
Tuberculosis, HIV
Adjunct Immunotherapy With Immunoxel in Patients With TB and TB/HIV
Dzherelo (Immunoxel) is an oral immunomodulating botanical agent available over-the-counter in Ukraine. After many years of laboratory and clinical testing the formulation was approved in 1997 by the Ministry of Health of Ukraine…
- Trial name
- NCT01061593
- Testing
- Immunoxel
- Where
- 2 sites in Mongolia, Ukraine
- Volunteers
- 269 people
- Sponsor
- Lisichansk Regional Tuberculosis Dispensary
MDR-TB, HIV
A Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection Outcomes
The researchers of this study are observing the treatment of multi-drug resistant Mycobacterium tuberculosis (MDR-TB) in South Africa. MDR-TB can not be treated with the usual TB drugs and needs to be treated with special drugs.
- Trial name
- NCT02129244
- Testing
- NCM-Plus
- Where
- 15 sites in South Africa
- Volunteers
- 2,844 people
- Sponsor
- Johns Hopkins University
HIV Infections
Testosterone for HIV-Positive Men With Reduced Serum Testosterone Levels and Abdominal Fat
The purpose of this study is to see if treatment with testosterone will reduce abdominal fat in HIV-positive men. Many HIV patients on antiretroviral therapy show an increase in abdominal fat.
- Trial name
- NCT00009555
- Testing
- Testosterone
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 86 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
H1N1 Vaccine at Two Dose Levels in HIV Positive Adults
The purpose of this study is to see how the body reacts to different strengths of the H1N1 flu shot in persons infected with human immunodeficiency virus (HIV).
- Trial name
- NCT00992433
- Testing
- Inactivated Influenza H1N1 vaccine
- Where
- 6 sites in United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Study to Evaluate the Safety and Immunogenicity of VPM1002 in Comparison With BCG in HIV-exposed/-Unexposed Newborn Infants in South Africa
Goal of Serum Institute of India Limited (SIIL) is the development of a recombinant urease C-deficient listeriolysin expressing BCG vaccine strain (VPM1002) as a safe, well tolerated and efficacious vaccine against tuberculosis…
- Trial name
- NCT02391415
- Testing
- VPM1002, BCG, VPM1002(Hyg+)
- Where
- 4 sites in South Africa
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Serum Institute of India Pvt. Ltd.
Infertility
Access to Infertility Services: Clinic Perspective
Since the identification of the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS) in the 1980s, there have been significant advances made in the management and long-term prognosis for infected…
- Trial name
- NCT00782132
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Child Maltreatment
Impact Evaluation Study of The Faithful House Programme on Violence Reduction in Families
The Faithful House (TFH), is a 3-day faith-based skills-building curriculum which aims to increase household resilience by strengthening families.
- Trial name
- TFHEVAL (NCT02168985)
- Testing
- TFH program
- Where
- Tanzania
- Volunteers
- 300 people
- Sponsor
- Savannas Forever Tanzania
HIV Infections, Renal Transplant Rejection
Switch to Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/F/TAF) After Renal Transplant
This is an open-label study, where participants will be switched from their current HIV medication to the study drug, BIC/F/TAF. Open-label means both the investigator and the participant will know what drug will be given.
- Trial name
- NCT04530630
- Testing
- BIC/F/TAF 50Mg-200Mg-25Mg Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
HIV/AIDS, Tuberculosis
Targeted Universal TB Testing With Simultaneous TPT Prescribing Among People Living With HIV in South Africa
Background: In 2023, the South African Department of Health introduced targeted universal TB testing (TUTT) at antiretroviral therapy (ART) initiation (irrespective of the presence of TB symptoms).
- Trial name
- TUTT-PT (NCT06739915)
- Testing
- TUTT-PT Intervention
- Where
- South Africa
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV, Cancer
Prospective HIV Chemotherapy Cohort Study
Human Immunodeficiency Virus (HIV) infection is very successfully treated with a type of therapy called Highly Active AntiRetroviral Therapy (HAART).
- Trial name
- NCT01902693
- Testing
- No intervention for this study
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Imperial College London