Clinical trials: HIV Infection Primary
HIV-1-Associated Cognitive Motor Complex
The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort -
To determine the prevalence of HIV associated Neurological Disorder (HAND) in a population of HIV positive patients within a primary care setting compared with the HIV negative population.
- Trial name
- CNS HAND (NCT01434563)
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Holdsworth House Medical Practice
Substance-Related Disorders, Human Immunodeficiency Virus
HIV & Drug Abuse Prevention for South African Men
The purpose of this study is to test the efficacy of randomizing all young men in a neighborhood to receive: 1) soccer training; 2) soccer and vocational training; or 3) a control condition, as a means to engage young men in HIV…
- Conditions
- Substance-Related Disorders, Human Immunodeficiency Virus, Alcoholism
- Trial name
- NCT02358226
- Testing
- Soccer League (SL), Soccer League/Vocational Training (SL-V)
- Where
- South Africa
- Volunteers
- 1,211 people
- Sponsor
- University of California, Los Angeles
HIV, Buprenorphine
Integrating Buprenorphine Into the SFGH AIDS Program
The purpose of this study is to assess the feasibility, cost, and effectiveness of a model of care designed to integrate buprenorphine treatment for opioid dependence into the HIV primary care clinics at the UCSF Positive Health…
- Conditions
- HIV, Buprenorphine, Opioid Dependence
- Trial name
- BHIVES-SF (NCT00263458)
- Testing
- Integrated office-based buprenorphine treatment for opioid dependence in an HIV primary care setting
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, San Francisco
HIV
Operational Assessment of Point-of-Care Diagnostics in Primary Healthcare Clinics
Diagnostic point-of-care (POC) tests are being rapidly developed and implemented in resource-limited settings. There has been a rapid rise of HIV and TB POC tests in South Africa during the last 10-15 years.
- Trial name
- NCT02692274
- Where
- South Africa
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Acute HIV Infection
Implementation of Nucleic Acid Amplification Testing Screening to Identify Acute and Early HIV Infection
The investigators propose to study the impact of nucleic acid amplification testing (NAT) screening for acute Human Immunodeficiency Virus (HIV) and Hepatitis C (HCV) infections and Less-Sensitive Enzyme linked Immunoassay…
- Trial name
- NCT01434706
- Testing
- Nucleic Acid Amplification Testing
- Where
- 5 sites in United States
- Volunteers
- 22,607 people
- Sponsor
- University of California, San Diego
Toxoplasmosis, Cerebral, HIV Infections
Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients
To evaluate the effectiveness of pyrimethamine (given with leucovorin calcium versus placebo (an inactive substance) for the primary prophylaxis (prevention) of cerebral toxoplasmosis in HIV-infected patients.
- Trial name
- NCT00000643
- Testing
- Pyrimethamine, Leucovorin calcium
- Where
- 24 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, Human Papilloma Virus
The Prevalence of Oral HPV Infection and Oral Lesions in People Living With HIV
The study will evaluate 300 people living with HIV that attend the Vivent Clinic for HIV care. We will characterize our population and include age, race/ethnicity, sex at birth, tobacco use, alcohol use, other comorbidities, HPV…
- Trial name
- SWISH (NCT06205511)
- Testing
- Oral HPV Sample
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Vivent Health
HIV/AIDS and Infections, Drug Abuse
Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention
The study evaluates the preliminary efficacy of an innovative mobile-health (mHealth) intervention (hereon referred to as S4E) to improve human immunodeficiency virus and sexually transmitted infection testing and reduce HIV/STI…
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03368456
- Testing
- S4E, Usual Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Maternal and Child Health
Evaluation of the Effectiveness of a Quality Improvement Intervention
This rigorous evaluation demonstrated that implementation of a time-limited quality improvement strategy effectively improved coverage of some components of an integrated maternal and child health service in a complex health…
- Trial name
- NCT04278612
- Testing
- Quality improvement intervention to strengthen health service provision
- Volunteers
- 1,438 people
- Sponsor
- University of KwaZulu
HIV Infections, Unstable Housing
Engagement in HIV Primary Care Services
This study is to look at things that may affect whether or not people who are HIV-infected get into medical care and stay in medical care.
- Trial name
- NCT00300170
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Montefiore Medical Center
HIV Positive
RETRIeVE: ReversE TranscRiptase Inhibitor hiV Practice
An observational retrospective study of NNRTI experienced patients who have virologically failed. The study aims to assess resistance profiling and subsequent prescription patterns of patients on NNRTIs
- Trial name
- NCT01154556
- Where
- Australia
- Volunteers
- 2,044 people
- Sponsor
- Holdsworth House Medical Practice
Tuberculosis
Utility of Sputum Induction and Novel Technologies to Improve TB Diagnosis in a High HIV Prevalence Primary Care Setting
This study will investigate the benefit of using Sputum induction for TB diagnosis in a primary care clinic for adult TB suspects that are either unable to produce a sputum sample (sputum scarce) or on initial diagnostic work-up…
- Trial name
- SINET (NCT01545661)
- Testing
- Sputum induction, standard routine expectorated sputum
- Where
- South Africa
- Volunteers
- 517 people
- Sponsor
- University of Cape Town
HIV, AIDS
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
This study will evaluate the efficacy of an integrated "Retention Clinic" in achieving virologic suppression among HIV-infected cocaine (including crack) users by using a two-group randomized, prospective trial.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- NCT01614106
- Testing
- Retention Clinic
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Primary Prevention of HIV Acquisition
Primary HIV Prevention in Pregnant and Lactating Ugandan Women
This study aims to test the effectiveness of a behavioral intervention aimed at preventing the primary acquisition of HIV by uninfected pregnant and lactating women in Uganda, East Africa where HIV transmission is high.
- Trial name
- PRIMAL (NCT01882998)
- Testing
- Extended repeat HIV testing and enhanced counseling
- Where
- Uganda
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Kidney Diseases, Type 2 Diabetes Mellitus
Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa
Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. The prevalence of CKD is increasing worldwide and is assumed to also dramatically increase in Sub-Saharan Africa (SSA).
- Conditions
- Chronic Kidney Diseases, Type 2 Diabetes Mellitus, Arterial Hypertension, Obesity
- Trial name
- RenalTWO (NCT05881447)
- Where
- Tanzania
- Volunteers
- 1,200 people
- Sponsor
- Swiss Tropical & Public Health Institute
Lymphoma
Combination Chemotherapy Plus Filgrastim in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00032149
- Testing
- bleomycin sulfate, filgrastim, cyclophosphamide
- Where
- 4 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Lymphoma Trials Office
Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections
Sexual Health Access at Retail Pharmacies: Advancing Pharmacy-based Delivery of Primary STI and HIV Prevention for Cisgender Women
This proposed 3-arm randomized study will compare different pharmacy based approaches that include HIV prevention medication (PrEP and PEP), routine STI testing, and preventive antibiotic (doxycycline) for STIs.
- Trial name
- SHARP (NCT07361926)
- Testing
- doxy-PEP, Serial STI testing, HIV PEP/PrEP
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
A Study of Anti-HIV Monoclonal Antibody KD-247
The purpose of this study is to evaluate the safety and tolerability of 3 infusions of KD-247 over 2 weeks in HIV-1 seropositive individuals; to determine the pharmacokinetic parameters of KD-247 when administered as above; and…
- Trial name
- NCT00917813
- Testing
- KD-247, Physiological saline
- Where
- 15 sites in United States
- Volunteers
- 27 people
- Sponsor
- The Chemo-Sero-Therapeutic Research Institute
HIV Infections
Preventing Sexual Transmission of HIV With Anti-HIV Drugs
This study will determine whether anti-HIV drugs can prevent the sexual transmission of HIV among couples in which one partner is HIV infected and the other is not.
- Trial name
- NCT00074581
- Testing
- Atazanavir, Didanosine, Efavirenz
- Where
- 17 sites in United States, Botswana and 7 more
- Volunteers
- 3,526 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS and Infections
A Randomised Placebo Controlled Trial of ART Plus Dual Long-acting HIV-specific Broadly Neutralising Antibodies (bNAbs).
RIO is a placebo-controlled double-blinded two arm prospective phase II randomised controlled trial . This study will test the use of broadly neutralising antibodies (bNAbs) in participants with treated primary HIV infection…
- Trial name
- RIO (NCT04319367)
- Testing
- Investigational Medicinal Product
- Where
- 12 sites in Denmark, United Kingdom
- Volunteers
- 72 people
- Sponsor
- Imperial College London