Clinical trials: HIV Infection, completed
Prevention of Infection With HIV-1
Safety Study of Ibalizumab Subcutaneous Injection in Healthy Volunteers
The is a blinded safety study of ibalizumab given by subcutaneous injection in sequentially increasing dose-groups of at-risk, HIV-negative, healthy volunteers.
- Trial name
- TMB-108 (NCT01292174)
- Where
- 6 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TaiMed Biologics Inc.
HIV, Substance Use Disorder (SUD)
Wellness, Intervention Strategies and HIV Care
This is a pilot trial designed to assess the feasibility and acceptability of an intervention aimed at improving adherence to antiretroviral therapy (ART), viral suppression, and engagement in HIV care.
- Trial name
- WISH (NCT07069374)
- Testing
- Wellness, Intervention Strategies and HIV Care (WISH), Movie Night Club - Attention and Time Matched Control
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of California, San Francisco
Healthy
A Study to Evaluate Safety, Acceptability, Pharmacokinetics, and ex Vivo Pharmacodynamics of TMC278 Long Acting Formulation in HIV-1 Seronegative Participants
The purpose of this study is to evaluate the safety, acceptability, pharmacokinetics (what the body does to the medication), and ex vivo (tested outside the body) pharmacodynamics (what the medication does to the body) of TMC278…
- Trial name
- NCT01656018
- Testing
- TMC278, Long acting (LA)
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Pre-Exposure Prophylaxis (PrEP)
Impact of Nursing Involvement on Implementation of HIV Prevention Services
Women comprise 20% of new Human Immunodeficiency Virus (HIV) diagnoses in the United States (U.S.) with 86% attributed to heterosexual contact.
- Trial name
- PrEP-RN (NCT05095818)
- Testing
- PrEP-RN
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Positive Youth That Are Newly Engaged in Care
Project ACCEPT: Engaging Newly Diagnosed HIV+ Youth in Care
The proposed study is a two-group randomized repeated measures design that will examine the efficacy of Project ACCEPT (Adolescents Coping, Connecting, Empowering and Protecting Together) to improve engagement in care among youth…
- Trial name
- NCT01751620
- Testing
- Project ACCEPT, HEALTH
- Where
- 4 sites in United States
- Volunteers
- 167 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
The Safety and Effectiveness of Two Forms of Saquinavir Combined With Other Anti-HIV Drugs in HIV-Infected Infants and Children
To determine the pharmacokinetic properties, tolerance and safety of 2 formulations of saquinavir, given in combination with 2 nucleoside antiretroviral drugs (part 1) or in combination with nelfinavir and nucleoside…
- Trial name
- NCT00002380
- Testing
- Nelfinavir mesylate, Saquinavir
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Hoffmann-La Roche
Hiv
Assessing Perceptions and Preferences Around Long-acting Injectables (APPLI)
The Ryan White HIV/AIDS Program is an essential platform for reducing health disparities among people with HIV and scaling up evidence-based strategies to strengthen the HIV care continuum.
- Trial name
- APPLI (NCT05833542)
- Testing
- Health education materials, Patient-provider decision tool
- Where
- 6 sites in United States
- Volunteers
- 243 people
- Sponsor
- City University of New York
HIV Infection
Characterization of the Adherence Threshold for HIV Suppression of a Kaletra-based Regimen
The hypothesis of this study is that the level of adherence necessary to achieve HIV virologic suppression with a ritonavir boosted protease inhibitor regimen (i.e.
- Trial name
- NCT00200369
- Testing
- MEMS cap
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Montefiore Medical Center
Inflammation, Macrophage Infiltration
Effectiveness of Sitagliptin for HIV Insulin Resistance and Inflammation
People living with human immunodeficiency virus infection (HIV) have 2-4fold greater risk for developing diabetes and heart disease than the general population.
- Conditions
- Inflammation, Macrophage Infiltration, Cardiovascular Disease
- Trial name
- NCT01552694
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
Infection, Human Immunodeficiency Virus
GSK706769 Repeat Dose Study
To determine safety, tolerability and Pharmacokinetics of GSK706769
- Trial name
- NCT00711386
- Testing
- GSK706769
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
A Clinical Study of the HIV Drug CPT31 in Healthy Volunteers
This first-in-human study will evaluate the safety, tolerability, immunogenicity, and pharmacokinetics of the HIV entry inhibitor CPT31 (cholesterol-PIE12-2-trimer) in healthy adults.
- Trial name
- NCT04672083
- Testing
- CPT31
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Navigen, Inc.
HIV-1-infection, HIV Associated Neurocognitive Disorder
HIV-1 Infected Adult Subjects With HIV-associated Neurocognitive Disorders Despite Effective Antiretroviral Therapy
Prospective study in HIV-1 infected adult subjects with HIV-associated neurocognitive disorders despite effective antiretroviral therapy in plasma for more than one year, analyzing the evolution of cognitive disorders and markers…
- Trial name
- NCT04266002
- Testing
- Validation of Charter score for the CNS diffusion of antiretroviral drugs
- Where
- 12 sites in France
- Volunteers
- 31 people
- Sponsor
- Hôpital Franco-Britannique-Fondation Cognacq-Jay
HIV, HBV
Efficacy and Safety of E/C/F/TAF (Genvoya®) in HIV-1/Hepatitis B Co-infected Adults
This study will assess the efficacy, safety, and tolerability of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) fixed-dose combination (FDC) in human immunodeficiency virus (HIV)/hepatitis B virus (HBV)…
- Trial name
- NCT02071082
- Testing
- E/C/F/TAF
- Where
- 24 sites in United States, Canada and 1 more
- Volunteers
- 79 people
- Sponsor
- Gilead Sciences
Cord Blood
Effects of Anti-HIV Therapy on Red Blood Cells of HIV-infected Mothers and Their Infants
This collaborative investigation between NIEHS, Duke University, and the University of North Carolina (UNC) will study red blood cells of babies born to HIV-infected women receiving anti-retroviral treatment.
- Trial name
- NCT00342082
- Where
- 3 sites in United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Risk Behavior, Mental Health Impairment
Randomized Controlled Trial of Ways to Improve OVC HIV Prevention and Well-being
The purpose of this study is to compare the effectiveness of two types of counseling, Psychosocial Counseling (PC) and Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), in addressing outcomes of orphans and vulnerable…
- Trial name
- NCT02054780
- Testing
- Trauma-Focused Cognitive Behavioral Therapy, Psychosocial Counseling
- Where
- Zambia
- Volunteers
- 610 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV/AIDS
Packaging PrEP to Prevent HIV Among WWID
Evidence suggests women who inject drugs (WWID) are disproportionately vulnerable to HIV. If HIV incidence continues unchecked, 1 in 23 WWID in the United States will acquire HIV.
- Trial name
- NCT03304912
- Testing
- PrEP Education and option to accept a PrEP prescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Drexel University
HIV
Addressing Discrimination and Mistrust Among Black Men: Phase III
The purpose of this research study is to test a group program aimed at improving the quality of life of HIV+ Black men who have sex with men.
- Trial name
- NCT02223130
- Testing
- Cognitive Behavioral Therapy techniques
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Children's Hospital
Methadone, HIV Infections
Recovery Management Intervention in China
The purpose of the study is to develop and pilot-test a Recovery Management Intervention (RMI) program for heroin addicts released from compulsory rehabilitation in China.
- Trial name
- NCT01270100
- Testing
- Recovery management
- Where
- China
- Sponsor
- University of California, Los Angeles
Kaposi's Sarcoma
Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS)
The purpose of this pilot study is to determine whether Maraviroc is effective in the treatment of Kaposi's Sarcoma (KS), when it does not remit with standard antiretroviral drug therapy.
- Trial name
- NCT01276236
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
Infection, Human Immunodeficiency Virus
Effect of Carbamazepine on Dolutegravir Pharmacokinetics in Healthy Adult Subjects
This study will be a phase I, open label, three period, fixed sequence crossover study to evaluate the effect of Carbamazepine (CBZ) on the steady-state pharmacokinetics of Dolutegravir (DTG) and on the safety and tolerability of…
- Trial name
- NCT01967771
- Testing
- DTG, CBZ
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
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