Clinical trials: HFrEF - Heart Failure With Reduced Ejection Fraction, open to volunteers
Chronic Heart Failure, Reduced Ventricular Ejection Fraction
CHF-COV Reduced (Chronic Heart Failure With Reduced Ejection Fraction - COngestion eValuation)
Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF.
- Trial name
- CHF-COVReduced (NCT05089162)
- Testing
- Clinical examination centered on congestion, Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds, Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Pr. Nicolas GIRERD
Heart Failure With Reduced Ejection Fraction
Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF
The goal of this clinical trial is to test a new type of pacemaker in heart failure patients following a heart bypass operation.
- Trial name
- RSA-PACE (NCT06384963)
- Testing
- Atrial pacing with respiratory sinus arrhythmia (RSA) variability, Monotonic right atrial overdrive pacing
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 54 people
- Sponsor
- Ceryx Medical Australia
Heart Failure With Reduced Ejection Fraction
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF).
- Trial name
- IICAPTAIN-HF (NCT06526988)
- Testing
- EPIC-HF Patient-facing Tool, PROMPT-HF Clinician-facing Alert
- Where
- 5 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- University of Colorado, Denver
Heart Failure With Reduced Ejection Fraction
Neuromuscular Fatigability in Individuals With Heart Failure
Brief summary The aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate…
- Trial name
- NCT06551012
- Testing
- Nitrate-rich beetroot juice, Beetroot juice with nitrate extracted
- Volunteers
- 28 people
- Sponsor
- Newcastle University
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
The FOCUS-ADHF Registry
Acute heart failure (AHF) represents a significant clinical and economic burden due to its impact on patients' quality of life, poor prognosis, and high healthcare costs.
- Conditions
- Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive, Regurgitation, Mitral
- Trial name
- FOCUS-ADHF (NCT06726109)
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 600 people
- Sponsor
- ASL Città di Torino
Heart Failure With Reduced Ejection Fraction
Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® Software
The goal of this clinical trial investigation with device is to determinate the effectiveness of remote monitoring of patients with heart failure with reduced ejection fraction heart (EFS40%) using Caaring® software.
- Trial name
- (CAARdioRING) (NCT06920160)
- Testing
- software Caaring (remote monitoring app)
- Where
- 2 sites in Spain
- Volunteers
- 196 people
- Sponsor
- Persei Vivarium
Heart Failure, Beta-blocker
N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure
In this study we seek to understand whether N-of-1 trials using a crossover withdrawal/reversal design with 1-5 three-week periods can be used to identify the highest tolerated beta-blocker dose for patients with Heart Failure…
- Conditions
- Heart Failure, Beta-blocker, Older Adults
- Trial name
- NCT07489352
- Testing
- N-of-1 trials, Enhanced usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes Mellitus (T2DM), Chronic Heart Failure (CHF)
Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction.
Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction--a multicenter randomized controlled study.
- Trial name
- GLID-HF (NCT07288749)
- Testing
- Glimepiride (oral)
- Where
- China
- Volunteers
- 1,484 people
- Sponsor
- Tongji Hospital
Congestive Heart Failure, Heart Failure, Systolic
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to…
- Conditions
- Congestive Heart Failure, Heart Failure, Systolic, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction
- Trial name
- MUSIC-HFrEF1 (NCT04703842)
- Testing
- SRD-001
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Sardocor Corp.
Cardiorenal Syndrome
Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients
This study aims to investigate the efficacy and safety of exercise rehabilitation in patients with cardiorenal syndrome (CRS). Building on previous research demonstrating that exercise rehabilitation can effectively improve…
- Trial name
- NCT07167368
- Testing
- Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction, Home-based Personalized Exercise Rehabilitation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Haiyan Pan
Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension, Right Heart Failure Due to Left Heart Failure
- Trial name
- HALT-RHF (NCT06299436)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Heart Failure With Reduced Ejection Fraction; Hypertension
Feasibility and Effectiveness of a Ring-Type Blood Pressure Device (CART-BP) Compared With 24-Hour Ambulatory Blood Pressure Monitoring in HFrEF
This study aims to evaluate the feasibility and diagnostic accuracy of the CART-BP ring-type wearable blood pressure monitoring device in comparison with 24-hour ambulatory blood pressure monitoring (ABPM) in patients with heart…
- Trial name
- RING-HFrEF (NCT07626879)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Keimyung University Dongsan Medical Center
Heart Failure, Heart Failure With Reduced Ejection Fraction
Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study
Describe the clinical characteristics, paraclinical features, and treatment during hospitalization, as well as at 1, 3, and 12 months post-discharge, of heart failure patients at selected cardiovascular centers in Vietnam.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Mid Range Ejection Fraction
- Trial name
- MCR-HF (NCT06516562)
- Testing
- Optimal treatment
- Where
- Vietnam
- Volunteers
- 2,500 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Chronic Stable Heart Failure
Qishenyiqi for Ventricular Remodeling After Myocardial Infarction
The effects of Qishenyiqi dripping pill on cardiac remodeling in patients with chronic stable heart failure have not been reported.
- Trial name
- NCT06699407
- Testing
- Qishenyiqi dripping pills
- Where
- 3 sites in China
- Volunteers
- 210 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Failure of Reduced Ejection Fraction (HFrEF)
Real-world Comparative Effectiveness and Safety of Jardiance in Chinese Patients With Heart Failure of Reduced Ejection Fraction
This study is to provide the effectiveness and safety evidence in patients with heart failure of reduced ejection fraction (HFrEF) initiating Jardiance in real clinical practice in a larger Chinese population.
- Trial name
- NCT07044700
- Testing
- Jardiance, non-SGLT2 inhibitors
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Boehringer Ingelheim
Heart Failure With Reduced Ejection Fraction
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
DigiCare-HFrEF is an investigator-initiated, multicentre, randomised, open-label, endpoint-blinded, superiority trial designed to evaluate whether a structured digital remote-management platform can optimise guideline-directed…
- Trial name
- DigiCare-HFrEF (NCT07352891)
- Testing
- Digital Remote Management
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Beijing Anzhen Hospital
Heart Failure With Reduced Ejection Fraction (HFrEF)
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
The primary purpose of the study is to evaluate the safety and efficacy of 2 doses of AC01 compared to placebo over 12 weeks in participants with chronic advanced HFrEF.
- Trial name
- GOAL-HF2 (NCT07584967)
- Testing
- AC01
- Volunteers
- 400 people
- Sponsor
- AnaCardio AB
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD)
- Trial name
- CARVTOP-ICD (NCT06964464)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Rochester
Heart Failure With Reduced Ejection Fraction (HFrEF), COPD (Chronic Obstructive Pulmonary Disease)
Metoprolol in Patients With HFrEF and COPD
The goal of the clinical trial was to see if Metoprolol was effective in treating patients with heart failure and chronic obstructive pulmonary disease. It will also learn about the safety of Metoprolol.
- Trial name
- NCT06825728
- Testing
- Different doses of Metoprolol.
- Volunteers
- 311 people
- Sponsor
- Xiangya Hospital of Central South University
Heart Failure, Heart Failure With Reduced Ejection Fraction
TRAnscutaneous vaGUS Nerve Stimulation in Patients With Chronic Heart Failure
To verify the efficacy of transcutaneous vagus nerve stimulation (tVNS) on and autonomic balance in patients with chronic heart failure and reduced (HFrEF) or mildly reduced (HFmrEF) left ventricular ejection fraction.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Midrange Ejection Fraction
- Trial name
- TRAGUS-HF (NCT06355388)
- Testing
- Active tVNS
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio