Clinical trials: HBV
HBV, Chronic Hepatitis B Virus
Prospective Cohort Study on PEG-IFN-α-2b in Improving Clinical Cure Rate of Pediatric Patients With Chronic Hepatitis B
In this study, comparisons will be made between the treatment group (which will receive pegylated interferon alfa-2b treatment) and the observation group (which will receive no drug treatment or be treated with nucleos(t)ide…
- Trial name
- NCT07231276
- Testing
- Peginterferon alfa-2b Injection
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Nanfang Hospital, Southern Medical University
HBV (Hepatitis B Virus), HBV Infection
Immune Dynamics in the Natural History of Chronic HBV Infection
The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural history of chronic HBV infection…
- Conditions
- HBV (Hepatitis B Virus), HBV Infection, Chronic Hep B
- Trial name
- NCT07137247
- Testing
- Venipuncture
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
HBV-related Liver Cirrhosis
A Study on Peginterferon Alfa-2b Combined With NAs in Compensated HBV Cirrhosis
This study is a multicenter, randomized, prospective trial designed to evaluate the efficacy and safety of pegylated interferon α-2b (Peg-IFN-α2b) combined with nucleos(t)ide analogues (NAs) versus NAs monotherapy in patients…
- Trial name
- NCT07183293
- Testing
- Peginterferon alfa-2b combined with NAs, NAs
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Xiamen Humanity Hospital
HBV Infection
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial to Evaluate the Efficacy and Safety of TVAX-008 Injection in Chronic Hepatitis B Patients
The objective of this study was to evaluate the efficacy and safety of TVAX- 008 injection in a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II clinical trial in subjects with HBSAg levels of…
- Trial name
- NCT07179653
- Testing
- TVAX-008
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Grand Theravac Life Sciences (Nanjing) Co., Ltd.
HBV-related Liver Cirrhosis
Risk Assessment for HBV-Related Liver Cancer
Liver cancer is a severe disease worldwide. The incidence and mortality rates of liver cancer in China is the highest in the world.
- Trial name
- NCT07160946
- Testing
- AI folow-up system
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Sun Yat-sen University
Liver Fibroses, HBV (Hepatitis B Virus)
Zinc Sulphate in Treatment Fibrosis in HBV Patient Receiving Antiviral Therapy
This study aims to investigate the possible safety and efficacy of Zinc sulphate as antifibrotic agent in chronic HBV patient receiving antiviral therapy.
- Trial name
- HBV (NCT07145268)
- Testing
- Entecavir (ETV), Zinc (zinc sulphate)
- Volunteers
- 44 people
- Sponsor
- Tanta University
HBV Infection, HCC - Hepatocellular Carcinoma
Clinical Trials of the Hepatitis B Sandwich Combination Therapy for Treating Patients Infected With Hepatitis B Virus
Primary objective: The main objective of this study is to assess the efficacy and safety of a sandwich combination therapy in patients who were infected with HBV or have undergone surgery for hepatitis B virus (HBV)-related…
- Trial name
- NCT07088133
- Testing
- NA(s)+HT-102+FD-001
- Volunteers
- 12 people
- Sponsor
- Shanghai Zhongshan Hospital
Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection
A Study to Predict Recompensation in Patients With Decompensated Cirrhosis Using Spleen Stiffness and Simple Blood Tests
The goal of this observational study is to learn if spleen stiffness and other non-invasive markers can help predict recompensation in people with decompensated cirrhosis who are receiving effective treatment for the cause of…
- Conditions
- Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Alcohol-Related Liver Disease
- Trial name
- LEAD-2 (NCT07087041)
- Where
- 28 sites in China
- Volunteers
- 735 people
- Sponsor
- Beijing Friendship Hospital
Hepatitis B, Chronic (CHB), Hepatitis B
Real-world Study Evaluating the Long-term Outcomes of Pegylated Interferon α-2b Treatment in the Families With Clusters of HBV Infection and Unfavorable Prognosis - A Prospective, Controlled, Multicenter, Cohort Study
Chronic hepatitis B can develop into cirrhosis and liver cancer, which seriously endangers the life and health of people. In China, HBV is mainly transmitted from mother to child, showing the phenomenon of family clusters.
- Conditions
- Hepatitis B, Chronic (CHB), Hepatitis B, Hepatitis B Virus (HBV)
- Trial name
- NCT07079150
- Testing
- Peg IFN-α-2b
- Where
- 2 sites in China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hepatitis B Reactivation, Hematopoietic Stem Cell Transplantation
Prophylactic Entecavir for HBV Reactivation in Past HBV Infected Patients With Hematopoietic Stem Cell Transplantation
This study is a randomized, prospective, comparative study of the effectiveness of prophylactic entecavir treatment for HBV reactivation in past HBV infected patients (HBsAg-, HBcIgG+) with allogeneic hematopoietic stem cell…
- Conditions
- Hepatitis B Reactivation, Hematopoietic Stem Cell Transplantation, Antiviral Drug, HBV
- Trial name
- NCT04942886
- Testing
- Baracle Tab.®
- Where
- South Korea
- Volunteers
- 226 people
- Sponsor
- Seoul St. Mary's Hospital
Hiv, HBV Coinfection
Towards a Functional Cure for HBV - The COMMIT Cohort Study
Hepatitis B virus (HBV) infection can be treated, but therapy is usually lifelong and has side effects, so a cure for HBV is a critical endpoint.
- Trial name
- COMMIT (NCT03645044)
- Where
- 3 sites in India, Malaysia and 1 more
- Volunteers
- 102 people
- Sponsor
- University of Melbourne
Hepatitis B Virus (HBV)
The Impact of Treatment for Chronic Hepatitis B Virus on Non-clinical Harms
The goal of this qualitative study is to explore the impact of antiviral treatment, or none, for chronic hepatitis B virus on the non-clinical (social) harms experienced by migrant populations living in the UK.
- Trial name
- B-SOCIAL (NCT07053449)
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
HEPATITIS C (HCV), Hepatitis B Virus (HBV)
Community Screening and Management of Hepatitis B, C and Delta in the Mongolian Population Living in France
In Mongolia, mortality from hepatocellular carcinoma (HCC) is one of the highest in the world. Viral hepatitis is the main cause of HCC: the prevalence of hepatitis B (HBV) estimated at 11% In Mongolia, hepatitis C (HCV) at 8.5%…
- Conditions
- HEPATITIS C (HCV), Hepatitis B Virus (HBV), Hepatitis D, Hepatocellular Carcinoma (HCC)
- Trial name
- Mondelta (NCT07038863)
- Testing
- Community screening for hepatitis B, C and delta in the Mongolian population living in France
- Where
- 11 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Hospices Civils de Lyon
HBV, HCC
Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
This study is a prospective, multicenter, real-world cohort study designed to compare the long-term outcomes of chronic hepatitis B patients with a family history of HBV-related hepatocellular carcinoma (HCC) who receive PEG…
- Trial name
- NCT07007286
- Testing
- ETV,TDF,TAF,TMF combination with PEG IFNα-2b, ETV,TDF,TAF or TMF
- Where
- 555 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Tenofovir Disoproxil Fumarate, Bone Density
Effect of Long-Term Use of Tenofovir (TDF) on Bone Density in Patients With Chronic Hepatitis B
This study aims to evaluate the effect of long-term use of Tenofovir Disoproxil Fumarate (TDF) on bone density in patients with chronic hepatitis B virus (HBV) infection.
- Conditions
- Tenofovir Disoproxil Fumarate, Bone Density, Chronic HBV Infection
- Trial name
- NCT06990438
- Testing
- TDF (Tenofovir)
- Where
- Egypt
- Volunteers
- 172 people
- Sponsor
- Assiut University
HBV, Chronic Hepatitis b
A Real-World Study of Antiviral Therapy in Children With Chronic Hepatitis B
This is a multicenter, prospective, real-world study. The study plans to include a total of 2000 patients who meet the inclusion and exclusion criteria, consisting of 1600 treatment-naive patients and 400 treatment-experienced…
- Trial name
- NCT06926647
- Testing
- Nucleos(t)ide Analogues, Interferon alfa, NAs combined with IFNα
- Where
- 85 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing 302 Hospital
Tenofovir Disoproxil Fumarate, Renal Function Disorder
Effect of Tenofovir (TDF) on Renal Function in Patients With Chronic Hepatitis B
Effect of Long-Term Use of Tenofovir (TDF) on Renal Function in Patients with Chronic Hepatitis B Over a Five-Year Period
- Conditions
- Tenofovir Disoproxil Fumarate, Renal Function Disorder, Chronic HBV Infection
- Trial name
- NCT06896630
- Testing
- Tenofovir Disoproxil Fumarate (TDF)
- Where
- Egypt
- Volunteers
- 172 people
- Sponsor
- Assiut University
Chronic Hepatitis B Virus (HBV) Infection
New HBV Infection Biomarkers: Clinical Characterization and Impact on Management
Chronic Hepatitis B Virus (HBV) infection affects nearly 300 million people worldwide and is a leading cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In France, it affects around 0.3% of the population.
- Trial name
- HBV-Biomark (NCT06906016)
- Testing
- Collection of blood samples for the study of HBV biomarkers
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV-1/HBV Co-Infection
Safety and Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir + Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment Naive, HIV-1 and Hepatitis B Co-Infected Adults
The primary objective of this study is to evaluate the efficacy of fixed-dose combination (FDC) of bictegravir/emtricitabine/ tenofovir alafenamide (B/F/TAF) versus dolutegravir (DTG) + emtricitabine/tenofovir disoproxil fumarate…
- Trial name
- Alliance (NCT03547908)
- Testing
- B/F/TAF, DTG, F/TDF
- Where
- 69 sites in United States, China and 12 more
- Volunteers
- 244 people
- Sponsor
- Gilead Sciences
Chronic Hepatitis B Virus (HBV) Infection, Liver Fibrosis
Non-Invasive Model for Fibrosis Regression in HBV Patients
A total of 1000 chronic hepatitis B (CHB) patients with liver biopsy performed at least 1 year after antiviral therapy are retrospectively enrolled. All the patients received NAs treatment.
- Trial name
- NCT06874127
- Testing
- Nucleos(t)ide Analogs (NA)
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Beijing Friendship Hospital