Clinical trials: Gynecologic Neoplasm
Cervical Cancer Screening, Gynecologic Cancers
Compliance to Cervical Cancer Chemoradiation Guidelines: A Multicentric Implementation Audit and Resource Assessment Initiative of National Cancer Grid of India
This is a combination of retrospective and prospective observational study that will be performed across NCG and other participating centers to report compliance to chemoradiation for cervical cancer.
- Conditions
- Cervical Cancer Screening, Gynecologic Cancers, Treatment Compliance, Chemoradiotherapy
- Trial name
- NCG-Compliance (NCT07290972)
- Testing
- Not applicable- observational study
- Where
- 2 sites in India
- Volunteers
- 618 people
- Sponsor
- Tata Memorial Hospital
Breast Cancer, Breast Neoplasm
Effects of Raloxifene on the Uterus and Ovaries of Premenopausal Patients
This research study is designed to work in cooperation with another study being conducted by the National Cancer Institute. The National Cancer Institute (NCI) is studying the effects of a drug called raloxifene on premenopausal…
- Trial name
- NCT00001837
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Acupuncture, Taste Disorders
Hypoglossal Acupuncture for Dysgeusia in Patients Undergoing Chemotherapy
This randomized controlled trial aims to investigate hypoglossal acupuncture in comparison to sham acupuncture and standard medical treatment (dietary recommendations) in the treatment of dysgeusia in cancer patients undergoing…
- Conditions
- Acupuncture, Taste Disorders, Dysgeusia, Chemotherapy
- Trial name
- OralAcu (NCT02304913)
- Testing
- Hypoglossal acupuncture, Dietary recommendations
- Where
- 3 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Universität Duisburg-Essen
Endometrium Cancer, Gynecologic Cancer
The Surveillance, Epidemiology, and End Results Database Program on Endometrial Cancer in the Italian Population
The aim of this study is to lay the bases for an ambitious project that reports and records all the epidemiological-clinical information of the cases of endometrial carcinoma diagnosed and treated in the reference oncology…
- Trial name
- ENDOCancerDATA (NCT07558889)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ERAS, Gynecologic Cancer
Adherence and Compliance to ERAS in Gynecological Surgery
The aim of the study is to investigate the association between early non-compliance to ERAS in postoperative day 2 (POD2) with the rate of postoperative complications.
- Conditions
- ERAS, Gynecologic Cancer, Post Operative Pain, Ovarian Cancer
- Trial name
- ERASGYNBS002 (NCT05738902)
- Testing
- Assessment of compliance to ERAS.
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Gynecologic Cancer
PROtein, Leucine and Vitamin D Supplementation In Patients With GYnecologic Cancer Receiving Platinum-based Chemotherapy
Open clinical trial addressing the effect of a nutritional support based on whey proteins, leucine and vitamin D on muscle mass and multiple anticancer treatment-related endpoints in patients with gynecologic cancer receiving…
- Trial name
- PRODIGY-1 (NCT06087783)
- Testing
- Experimental product - Fortifit® Powder, Standard of care
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Gynecologic Cancer, Neuropathy;Peripheral
The Effect of Low Frequency Soundwave Stimulation on Chemotherapy Induced Peripheral Neuropathy
The goal of this clinical trial is to assess the efficacy of SensoniQ® Treatment Station in preventing or reducing chemotherapy induced peripheral neuropathy symptoms (CIPNS) in patients receiving frontline carboplatin and…
- Trial name
- NCT05980169
- Testing
- SensoniQ Treatment Station
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Augusta University
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Advanced Solid Tumor, Gynecologic Cancer
A Study of PY314 in Subjects With Advanced Solid Tumors
This is an open-label, multicenter, first in human, Phase 1a/1b study of PY314 in subjects with locally advanced (unresectable) and/or metastatic solid tumors that are refractory or relapsed to standard of care (including…
- Conditions
- Advanced Solid Tumor, Gynecologic Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT04691375
- Testing
- PY314, Combination Therapy: PY314 + Pembrolizumab
- Where
- 23 sites in United States
- Volunteers
- 86 people
- Sponsor
- Ikena Oncology
Ovarian Carcinoma, Cervical Carcinoma
Contribution of Oncovascular Surgery in the Treatment of Gynecological Advanced Malignant Diseases.
Multicenter ambispective observational study (prospective/retrospective)
- Conditions
- Ovarian Carcinoma, Cervical Carcinoma, Endometrial Carcinoma, Vulvar Carcinoma
- Trial name
- NCT07267780
- Where
- 2 sites in Italy
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute, Naples
Uterine Cervical Neoplasms, Uterine Neoplasms
Guided Imagery in the Perioperative Period in Gynecologic Oncology Patients
The purpose of this study is to evaluate the effectiveness of self-administered perioperative guided imagery to reduce perioperative distress in gynecologic oncology patients undergoing surgical management for a presumed cancer…
- Conditions
- Uterine Cervical Neoplasms, Uterine Neoplasms, Ovarian Neoplasms, Urogenital Neoplasms
- Trial name
- NCT02444195
- Testing
- Guided Imagery With Audio Media
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Michigan
Breast Cancer, Genitourinary Cancer
Inflammatory Response and Tissue Fibrosis/ Lymphatico-venous Bypass
The goal of this clinical research study is to measure the amount of inflammatory proteins inside the body before and after lymphatico-venular bypass surgery.
- Conditions
- Breast Cancer, Genitourinary Cancer, Malignant Female Reproductive System Neoplasm, Melanoma
- Trial name
- NCT01433302
- Testing
- Punch Biopsy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Gynecologic Cancer
[18F] Flourothymidine (FLT) PET/CT Imaging for Gynecologic Cancers
The purpose of this study is to determine the effect of specific bone marrow maps developed with18F-FLT PET/CT imaging on the ability to spare proliferating bone marrow using proton beam radiotherapy compared to IMRT.
- Trial name
- NCT02108457
- Testing
- [18F]Fluorothymidine (FLT) PET/CT Imaging
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cervical Cancer, Endometrial Cancer
Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy
This randomized, pilot phase I trial studies whether phone or email reminders increases vaginal dilator use in patients with endometrial, cervical, or vaginal cancers after they undergo brachytherapy.
- Conditions
- Cervical Cancer, Endometrial Cancer, Radiation Toxicity, Vaginal Cancer
- Trial name
- NCT02058550
- Testing
- survey administration, computer-assisted intervention, telephone-based intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Pelvic Radiotherapy, Vaginal Stenosis
Vaginal Dilator Therapy After Pelvic Radiation
This study is testing a new program to help women who have had pelvic radiation therapy to use vaginal dilators more regularly. Vaginal dilators are important tools that can help prevent or treat vaginal narrowing (called vaginal…
- Conditions
- Pelvic Radiotherapy, Vaginal Stenosis, Pelvic Cancer, Gynecologic Cancers
- Trial name
- NCT07216456
- Testing
- Improving Engagement with Vaginal Dilator Therapy after Pelvic Radiation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University
Breast Cancer, Gynecologic Cancer
Pilot Observational Study of an Integrative Cure Stay Program
This pilot observational study evaluates the feasibility and acceptability of conducting a prospective study alongside the individualized integrative oncology cure stay program "Via Shalva" for breast and gynecological cancer…
- Trial name
- Via Shalva (NCT07398079)
- Testing
- Integrative Cure Stay, Matched Control Group
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Gynecologic Cancer
Telehealth & HPV Self-Collection
This study aims to compare the efficacy and participant experience of telehealth-based, self-collected cervical cancer screening to mail-based, self-collected cervical cancer screening across the adult female screening lifespan.
- Trial name
- NCT05089825
- Testing
- Receive routine instructions, Telehealth-based instructional visit and receive routine instructions
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Gynecologic Disease, Gynecologic Cancer
Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology
GynRAN is an international, multicentre, transversal, diagnostic and non-interventional study carried out in gynecology-obstetrics/gynecological oncology departments that aims to identify a diagnostic signature for gynecological…
- Conditions
- Gynecologic Disease, Gynecologic Cancer, Endometriosis, Ovarian Cancer
- Trial name
- GynRNA (NCT06392997)
- Testing
- Saliva sample
- Where
- 13 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- ZIWIG
Breast Cancer, Brain Cancer
Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
This phase I dose escalation study will evaluate IGF-Methotrexate conjugate (765IGF-MTX) in patients with advanced, previously treated tumors.
- Conditions
- Breast Cancer, Brain Cancer, Gastrointestinal Cancers, Genitourinary Cancers
- Trial name
- NCT02045368
- Testing
- IGF-Methotrexate conjugate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- IGF Oncology, LLC
Hysterectomy, Minimal Invasive Surgery
Comparative Study of LAVH and Minilaparotomy Hysterectomy
Minilaparotomy hysterectomy (MLH) relies on the simplicity of traditional open technique of abdominal hysterectomy, imparts cosmesis and faster recovery of laparoscopic hysterectomy yet avoids the long learning curve, cost of…
- Conditions
- Hysterectomy, Minimal Invasive Surgery, Benign Gynecologic Neoplasm
- Trial name
- LAVH (NCT03548831)
- Volunteers
- 52 people
- Sponsor
- Manipal University