Clinical trials: Gulf War Illness
Gulf War Illness
Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness
Gulf War Illness (GWI) is a multi-symptom disorder that is characterized by complex traits such as fatigue, headaches, joint pain, insomnia, and memory problems.
- Trial name
- NCT02915237
- Testing
- Concord grape juice
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gulf War Syndrome, Persian Gulf Syndrome
Coenzyme Q10 for Gulf War Illness: A Replication Study
The purpose of this study is to assess whether a high quality preparation of ubiquinone (coenzyme Q10) benefits symptoms, function, and quality of life in veterans with Gulf War illness.
- Conditions
- Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorder, Respiratory Chain
- Trial name
- NCT06515184
- Testing
- PharmaNord Bio-Quinone Active CoQ10 Gold 100mg
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of California, San Diego
Gulf War Illness
Identification of Gulf War Illness (GWI) Biomarkers
The scientists working on this study want to use blood samples to identify components in blood, such as protein, lipids and their breakdown products to determine if they can be used for diagnosing Gulf War Illness (GWI).
- Trial name
- NCT03082638
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Roskamp Institute Inc.
Chronic Multisymptom Illness in Gulf War Veterans
Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness
Following their deployment to the 1991 Gulf War, many veterans (GWV) reported a constellation of unexplained health symptoms; common among them were attention and memory difficulties, fatigue, joint pain, headaches…
- Trial name
- NCT01802944
- Testing
- Intranasal Insulin
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc
Gulf War Syndrome, Chronic Fatigue Syndrome
Hyporeactivity and Gulf War Illness
This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation.
- Conditions
- Gulf War Syndrome, Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder
- Trial name
- NCT00100412
- Testing
- Graded dobutamine infusions, Graded phenylephrine injections, Psychosocial challenge involving socioevaluative public speaking
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Gulf War Syndrome
START & STOPP in GWI
Gulf War Illness (GWI) veterans were divided into 2 pathophysiological groups based on their orthostatic tachycardia responses after submaximal exercise.
- Trial name
- START (NCT03560830)
- Testing
- 2 submaximal exercise stress tests
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Gulf War Illness
NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)
Background: Gulf War illness (GWI) affects up to 210,000 U.S. veterans who served in the Middle East during the Gulf War in 1990-1991.
- Trial name
- NCT05375812
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Gulf War Illness, Chronic Fatigue
Coenzyme Q10 Phase III Trial in Gulf War Illness
The primary objective of this clinical trial is to determine if treatment with ubiquinol, a form of coenzyme Q10, improves the physical function of men and women Veterans suffering from Gulf War Illness (GWI).
- Conditions
- Gulf War Illness, Chronic Fatigue, Ubiquinol, Coenzyme Q10
- Trial name
- NCT02865460
- Testing
- Ubiquinol
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Brain Blood Flow, Neurovascular Control
Cardiovascular and Neurovascular Regulation in GWI
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
- Trial name
- NCT04586049
- Testing
- MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Gulf War Veterans' Illness
CAM in Veterans With Gulf War Illnesses
The purpose of this study is to explore the effectiveness Gulf War Health Education (GWHE) and iRest Yoga Nidra (mindfulness meditation)/auricular (ear) acupuncture for Veterans with Gulf War Veterans' Illnesses (GWVI).
- Trial name
- GW-CAM (NCT02180243)
- Testing
- Mindfulness meditation/Acupuncture, Gulf War Health Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Pain, Migraine
Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness
The researchers propose studying Gulf veterans with Gulf War Illness (GWI), characterized by a problem with widespread pain. Besides their pain, the researchers will also assess the effect of vagus nerve stimulation (VNS) in…
- Trial name
- NCT02791893
- Testing
- VNS device, Inactive device
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Benjamin Natelson
Gulf War Illness
Resistant Potato Starch to Alleviate GWI
Gulf War Illness (GWI) affects an estimated 25-32% of the over 700,000 coalition troops deployed to the Persian Gulf as part of the First Gulf War.
- Trial name
- NCT05820893
- Testing
- Resistant Potato Starch
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness
OEA for Targeting Lipid Metabolism in GWI
The study is a single site, randomized, double-blind, placebo-controlled study with an open label extension to evaluate the effects of Oleoylethanolamine (OEA) on blood lipid and immune biomarkers in participants with Gulf War…
- Trial name
- NCT05252949
- Testing
- Oleoylethanolamide (OEA)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Gulf War Illness, Irritable Bowel Syndrome
Mechanisms of Gulf War Illness
Many veterans with Gulf War Illness developed chronic gastrointestinal symptoms during their deployment to the Persian Gulf. The pathophysiologic mechanisms of these chronic gastrointestinal symptoms are not well understood but…
- Conditions
- Gulf War Illness, Irritable Bowel Syndrome, Gastrointestinal Symptoms
- Trial name
- NCT05972291
- Testing
- Oral Glutamine, Control Arm
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Thermal Clinic Treatment in Gulf War Illness
Although thermal therapy has been utilized in the rehabilitation of war veterans since the Roman Empire, no investigations actually exist about the use of thermal therapy in GWI, This due to the fact that nobody knows that the…
- Trial name
- TCTGWI (NCT02293291)
- Testing
- Lithium Water
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- American Society Of Thermalism And Climatology Inc
Gulf War Illness, Chronic Fatigue
Ca-Mg Butyrate in Gulf War Illness
The primary objective of this clinical trial is to determine if treatment with Butyrate formulation that consists of butyric acid as calcium and magnesium derivatives (Ca-Mg Butyrate) improves the physical function of men and…
- Conditions
- Gulf War Illness, Chronic Fatigue, Neurocognitive Dysfunction
- Trial name
- Butyrate (NCT05367245)
- Testing
- Cal-Mag Butyrate
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness
Methylphenidate Plus GWI-Nutrient Formula as a Treatment for Patients With Gulf War Illness
The Gulf War Synergy Trial will evaluate the safety and efficacy of a currently available medication, methylphenidate (Ritalin®), combined with a GWI Nutrient Formula (K-PAX Synergy) to treat Gulf War Illness (GWI).
- Trial name
- NCT02357030
- Testing
- Methyl-P plus GWI Nutrient Formula
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- K-PAX Pharmaceuticals, Inc.
Gulf War Syndrome
Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness
The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage.
- Trial name
- NCT07266571
- Testing
- Pycnogenol, 100mg, Pycnogenol, 200mg, Pycnogenol, 400mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Illness
Pilot Test of Apnea and Insomnia Relief for Veterans With Gulf War Illness
The purpose of this study is to determine whether a behavioral sleep treatment improves sleep and other Gulf War Illness (GWI) symptoms in Gulf War Veterans with GWI.
- Trial name
- GWAIR (NCT05137743)
- Testing
- Apnea and Insomnia Relief (AIR), Sleep Education (SE)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of California, San Francisco
Gulf War, Fatigue
Groups for Regaining Our Wellbeing
This study is a randomized clinical trial measuring outcomes up to 6-months post-intervention. The objective of this study is to evaluate outcomes of two different group interventions for Veterans with Chronic Multisymptom…
- Conditions
- Gulf War, Fatigue, Pain, Depression
- Trial name
- GROW (NCT03058952)
- Testing
- Mindfulness-Based Stress Reduction, Chronic Disease Self-Management Program
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- VA Office of Research and Development