Clinical trials: Guidelines, open to volunteers
Uterine Cervical Neoplasms, Cervical Cancer
Clinical Efficacy of Adjuvant Chemotherapy in Patients With Locally Advanced Cervical Cancer Who Did Not Meet the NCCN Guidelines for Adjuvant Treatment After NACT Combined With Surgery
This is a prospective, phase 3 randomized controlled clinical trial. Cervical cancer patients with FIGO stage IB3, Ⅱ A2 or IIB with tumor size> 4 cm will be enrolled.
- Trial name
- NCT04733820
- Testing
- Adjuvant chemotherapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Huazhong University of Science and Technology
HIV
Behavioral Risk Identification and Decision Guidance for HIV Engagement
Despite much progress towards reaching UNAIDS goals for HIV treatment, disengagement from care remains one of the biggest obstacles to HIV elimination.
- Trial name
- BRIDGE (NCT07439003)
- Testing
- Retention toolkit to improve HIV treatment outcomes during the early treatment period
- Where
- South Africa
- Volunteers
- 15,270 people
- Sponsor
- Boston University
Chronic Coronary Syndrome
Chronic Coronary Syndrome Snapshot Study
The goal of this observational study is to evaluate the current adherence to the 2019 European Society of Cardiology (ESC) Guidelines on Chronic Coronary Syndrome among healthcare professionals and identify potential barriers and…
- Trial name
- C2S2 (NCT06748924)
- Where
- Armenia
- Volunteers
- 4,000 people
- Sponsor
- European Society of Cardiology
Heart Failure With Reduced Ejection Fraction
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
DigiCare-HFrEF is an investigator-initiated, multicentre, randomised, open-label, endpoint-blinded, superiority trial designed to evaluate whether a structured digital remote-management platform can optimise guideline-directed…
- Trial name
- DigiCare-HFrEF (NCT07352891)
- Testing
- Digital Remote Management
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Beijing Anzhen Hospital
Enhance Care to Victims of Violence
Testing and Evaluating a Psychoeducation Tool and Guidelines for Victims of Violence in Belgian Hospitals.
The "Operation Alert/Operatie Alert/Opération Alerte" project, developed by UGent-ICRH and UZGent with funding from the Belgian Federal Public Service for Health, focuses on strengthening basic competencies to better and more…
- Trial name
- Operatie Alert (NCT06780540)
- Testing
- Operation Alert: Support prgram
- Where
- 10 sites in Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Major Adverse Cardiovascular Events, Cardiovascular Testing and Consultation Intensity
How Institutional Guidelines for Urgent Inpatient Surgeries Affect Intensity of Perioperative Cardiovascular Testing
This study will evaluate the impact of implementing an educational clinical decision support (CDS) tool designed to guide perioperative cardiovascular evaluation for adults undergoing urgent inpatient surgery.
- Trial name
- NCT07692503
- Volunteers
- 3,000 people
- Sponsor
- Johns Hopkins University
Atrial Fibrillation, Atrial Flutter
Get With the Guidelines Atrial Fibrillation Registry
Get With The Guidelines-Atrial Fibrillation is designed to assist hospital care teams in consistently providing the latest evidence-based treatment for their AFib patients.
- Trial name
- GWTG-AF (NCT06245187)
- Testing
- GWTG Atrial Fibrillation program
- Where
- United States
- Volunteers
- 17,198 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Joint Hypermobility
Characteristics of the Functional State of the Musculoskeletal System, Body Awareness, and Quality of Life in Individuals With Joint Hypermobility, Their Associations, and Guidelines for Intervention.
The goal of this observational study is to learn about the characteristics of the functional state of the musculoskeletal system, body awareness, and quality of life in individuals with joint hypermobility, their associations…
- Trial name
- NCT07476976
- Testing
- No intervention
- Where
- Lithuania
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Airway Assessment
Airway Survey - International Airway Assessment Practices (2023-2028)
This international, multicenter, observational survey study aims to assess current clinical practices in preoperative airway assessment in Germany, Austria, and Switzerland at both the institutional and individual…
- Trial name
- AirwaySurvey (NCT07886060)
- Testing
- Structured Survey on Preoperative Airway Assessment
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Stroke
Get With the Guidelines-Stroke Registry
Get With The Guidelines-Stroke is a program for improving the quality of care for patients hospitalized with stroke by promoting consistent adherence to the latest evidence-based clinical practice guidelines.
- Trial name
- GWTG-Stroke (NCT02693223)
- Testing
- GWTG Stroke program
- Where
- United States
- Volunteers
- 3,892,063 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Syncope, Fall
Global Approach to Faint and Falls
Syncope is the most frequent cause of transient loss of consciousness. Falls are very common in older people. If the falls are unexplained and not accidental, it is likely that the patient had a syncope event and showed a lack of…
- Trial name
- F2 (NCT05752682)
- Testing
- Diagnostic pathway
- Where
- Italy
- Volunteers
- 340 people
- Sponsor
- Istituto Auxologico Italiano
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Heart Failure With Reduced Ejection Fraction, Heart Failure
STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure
This is a multicenter, randomized, open-label pilot study to evaluate whether stepwise withdrawal of two heart failure medications-angiotensin receptor-neprilysin inhibitor (ARNI) and sodium-glucose cotransporter-2 inhibitor…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure, Ventricular Dysfunction, Left
- Trial name
- STEP-DOWN HF (NCT07631156)
- Testing
- Stepwise Withdrawal of ARNI and SGLT2i, Continued Guideline-Directed Medical Therapy
- Where
- 5 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Kyungsub Song
Diabetic Kidney Disease, Type 2 Diabetes
Improving Kidney Care in Type 2 Diabetes: A Study of Pharmacist Prescribing Versus Usual Care
Type 2 diabetes is the leading cause of chronic kidney disease, which can result in serious complications such as kidney failure and heart disease.
- Conditions
- Diabetic Kidney Disease, Type 2 Diabetes, Chronic Kidney Disease
- Trial name
- RX4DKD (NCT07169422)
- Testing
- Usual care for diabetic kidney disease management without primary care provider., Pharmacist-led validated diabetic kidney disease decision support algorithm.
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Nova Scotia Health Authority
Heart Failure With Preserved Ejection Fraction
Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction
To assess the impact of PADN combined with guideline-directed medical therapy (GDMT) versus a sham procedure with GDMT on clinical outcomes in heart failure (HF) patients with preserved left ventricular ejection fraction…
- Trial name
- PADN-HFpEF (NCT07331220)
- Testing
- PADN, GDMT
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Backpain, Neck and Shoulder Pain
Implementation of Evidence-based Guidelines for Assessment and Counseling of Patients With Neck and Back Pain in Health Care Centers
The overall aim is to investigate the health outcomes and consequences, from an individual and a societal perspective, of adding licensed Manual Therapists as first-contact healthcare providers in Primary Health Care centers to…
- Trial name
- ALIGN (NCT07825116)
- Testing
- Manual terapeut management
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska Institutet
ASCVD
Improving Implementation of Guideline-Recommended LDL-C Management in High-Risk Cardiovascular Patients
The goal of this observational study is to learn whether implementing evidence-based strategies in cardiology practices can improve guideline-recommended low-density lipoprotein cholesterol (LDL-C) management in adults at high…
- Trial name
- EMPOWER (NCT07883564)
- Where
- 5 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Cardiology Consultants of Philadelphia
Low Back Pain
A Multilevel Intervention for Low Back Pain Management in Primary Care
Low back pain is the leading cause of disability worldwide and one of the main reasons for consulting in primary care. This project aims to improve the management of people with low back pain in primary care through an innovative…
- Trial name
- PRIME Back (NCT07137065)
- Testing
- PRImary care MultilEvel intervention for low back pain (PRIME), Usual Care
- Where
- 2 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- Guillaume Christe
Soft Tissue Sarcoma (STS)
Sarcoma Care Adherence and Survival in Strasbourg
This retrospective monocentric study evaluates adherence to international clinical practice guidelines for soft tissue sarcoma management in Strasbourg and its impact on overall survival.
- Trial name
- SAGES (NCT07864870)
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Strasbourg, France
Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease
PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF
To evaluate whether percutaneous coronary intervention (PCI) with contemporary drug-eluting stents (DES) combined with guideline-directed medical therapy (GDMT), compared to GDMT alone, reduces the time to first occurrence of…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease, Stable GDMT
- Trial name
- PCI-GULF (NCT07349979)
- Testing
- Percutaneous coronary intervention, Guideline-directed medical therapy
- Where
- China
- Volunteers
- 1,154 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University