Clinical trials: Growth Hormone
Hypogonadism, Precocious Puberty
Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle
OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone (GnRH) and sex steroid secretion in normal and hypogonadal children. II.
- Trial name
- NCT00004335
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Growth Hormone Deficiency
Evaluation of Efficacy and Safety of Recombinant Somatroipn in Patients With Growth Hormone Deficiency
The purpose of this study is to evaluate the efficacy and safety of recombinant human growth hormone on adult growth hormone deficiency
- Trial name
- NCT02693522
- Testing
- somatropin, Eutropin
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Adult Growth Hormone Deficiency
MOD-4023 (Long-Lasting Human Growth Hormone (hGH)) Study in Growth Hormone Deficient Adults (GHDA)
This study aims to assess the safety, tolerability and Pharmacokinetics/ Pharmacodynamics (PK/PD) profile of three doses of MOD-4023 on a weekly regime and one dose on an every-other-week regime administered for a period of 4…
- Trial name
- NCT01225666
- Testing
- MOD-4023
- Where
- 15 sites in Czechia, Hungary and 4 more
- Volunteers
- 52 people
- Sponsor
- OPKO Health, Inc.
Metastatic Breast Cancer, Locally Advanced Breast Cancer
HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer
The main purpose of this research study is to learn whether the investigational combination of olaparib, palbociclib, and fulvestrant is safe in patients with estrogen receptor-positive breast cancer and BRCA1 or BRCA2 mutations.
- Conditions
- Metastatic Breast Cancer, Locally Advanced Breast Cancer, Advanced Breast Cancer, BRCA2 Mutation
- Trial name
- NCT03685331
- Testing
- Palbociclib, Olaparib, Fulvestrant
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Adult Growth Hormone Deficiency, Growth Hormone Disorder
A Trial to Compare the Safety of Once Weekly Dosing of Somapacitan With Daily Norditropin® FlexPro® for 26 Weeks in Previously Human Growth Hormone Treated Adults With Growth Hormone Deficiency
This trial is conducted in Europe and Asia. The aim of the trial is to compare the safety of once weekly dosing of somapacitan (administered with an investigational pen) with daily Norditropin® FlexPro® (somatropin delivered…
- Trial name
- REAL 2 (NCT02382939)
- Testing
- somapacitan, somatropin
- Where
- 28 sites in Denmark, France and 4 more
- Volunteers
- 92 people
- Sponsor
- Novo Nordisk A/S
Juvenile Idiopathic Arthritis, Still Disease, Juvenile-Onset
Efficacy and Safety of Growth Hormone Treatment in Juvenile Idiopathic Arthritis
Growth retardation is well known in patients with severe forms of juvenile idiopathic arthritis. Especially those who were under additional treatment with glucocorticoids for high disease activity.
- Trial name
- NCT00420251
- Testing
- Genotropin
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Safety and Efficacy of Somatropin in Children With Growth Hormone Deficiency
This trial is conducted in the United States of America (USA). The aim of this trial is to evaluate the safety profiles of Norditropin® (lyophilized somatropin) and Norditropin® cartridges (liquid somatropin) in children with…
- Trial name
- NCT01502124
- Testing
- somatropin
- Where
- 21 sites in United States
- Volunteers
- 78 people
- Sponsor
- Novo Nordisk A/S
Growth Hormone Deficiency
Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency
The aim of the study is to determine the specificity and sensitivity of the combined growth hormone releasing hormone (GHRH) + Arginine test in healthy volunteers, subjects with highly probable adult growth hormone deficiency…
- Trial name
- NCT01060488
- Testing
- GHRH+Arg, GHRH+Arg, ITT, ITT, ITT, GHRH+Arg.
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Craniocerebral Trauma, Hypothalamic-pituitary Disorders
Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort
The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.
- Conditions
- Craniocerebral Trauma, Hypothalamic-pituitary Disorders, Pediatric, Endocrinology
- Trial name
- ENDOC TC 2 (NCT07533435)
- Testing
- Telephone questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Growth Disorder, Small for Gestational Age
French National Registry of Children Born Small for Gestational Age Treated With Somatropin
This study is conducted in Europe. The aim of the study is to describe the patient population and therapeutic practices (study phase I), assess efficacy on growth and adult height and assess tolerance of somatropin (Norditropin®…
- Trial name
- NCT01578135
- Testing
- somatropin
- Where
- France
- Volunteers
- 291 people
- Sponsor
- Novo Nordisk A/S
Obesity
Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls
Teenagers and adults who are overweight or obese have an increase in fat in the abdomen, which increases their risk for diabetes and heart disease.
- Trial name
- NCT01169103
- Testing
- recombinant human growth hormone (rhGH)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Acromegaly Due to Pituitary Adenoma, Difficult Intubation
Ultrasound in Predicting Difficult Intubation in Acromegaly Patients
This is a prospective observational study.The purpose of this study is to predict difficult intubation with ultrasonographic evaluation combined with preoperative physical examination in patients diagnosed with acromegaly and…
- Conditions
- Acromegaly Due to Pituitary Adenoma, Difficult Intubation, Airway Ultrasonography
- Trial name
- NCT07306325
- Testing
- observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Lactation
Growth Hormones and Cells in Human Milk Depending on Gestational Age
Human breast milk contains growth factors including neurotrophins and cells with neuroprotective potential. Concerning growth factors milk of preterms differs significantly from term milk.
- Trial name
- BMProfile (NCT02662517)
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Growth Hormone Deficiency, Short Stature
Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy
The primary objective of the study is to evaluate the epigenetic age in children with GH deficiency, before and after 6 months of treatment with growth hormone replacement therapy.
- Trial name
- ETABIOGHD (NCT06294860)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Auxologico Italiano
Human Immunodeficiency Virus, Growth Hormone Treatment
Impact of Recombinant Human Growth Hormone on HIV Persistence
Antiretroviral therapy (ART) has improved the health of more than 18 million people infected with HIV by controlling viral replication, AIDS and non-AIDS events, and by reducing the risk of transmission.
- Trial name
- NCT03091374
- Testing
- Somatotropin (Human)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Acromegaly, Excessive Growth Hormone Secretion
Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.
- Conditions
- Acromegaly, Excessive Growth Hormone Secretion, Insulin Resistance
- Trial name
- NCT00647179
- Testing
- Transsphenoidal adenomectomy
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Growth Hormone Disorder, Adult Growth Hormone Deficiency
A Single Dose Trial in Healthy Caucasians and Japanese Subjects Investigating the Pharmacokinetics of Somatropin
This trial was conducted in the United States of America (USA). The aim of this clinical trial was to investigate the pharmacokinetics of somatropin in healthy Japanese and Caucasian subjects, and to identify somatostatin-related…
- Conditions
- Growth Hormone Disorder, Adult Growth Hormone Deficiency, Healthy
- Trial name
- NCT00931476
- Testing
- somatropin
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Infertility, Poor Ovarian Reserve
Growth Hormone for Poor Responders in in Vitro Fertilization (IVF)
The purpose of this study is to determine if growth hormone given 4 weeks before as well as during a cycle of in vitro fertilization will improve outcomes in women who have had previous failure with IVF treatment cycles using…
- Trial name
- NCT01204840
- Testing
- Growth Hormone, Patch protocol
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ottawa Fertility Centre
Growth Hormone Deficiency
Transition Study: Growth Hormone Therapy In Partial Growth Hormone Deficient Adolescents
To evaluate in boys and girls the improvement in body composition under GH treatment in adolescents with CO-GHD who remain partially GHD after GH discontinuation.
- Trial name
- TAUBER (NCT00156143)
- Testing
- Blood sample, Radiography
- Volunteers
- 90 people
- Sponsor
- Pfizer