Clinical trials: Group B Streptococcus
Gestational Mother, Streptococcus Agalactiae Infection
Colonization with Group B Streptococcus During Pregnancy
An observational study to estimate the probability of pregnant women, who were GBS-negative in the first trimester of pregnancy become GBS-positive at the end of pregnancy. It is an observational.
- Trial name
- PROBIGEST (NCT03671486)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ProbiSearch SL
Invasive Group B Streptococcal Disease
Burden of Invasive Group B Streptococcal Disease in Infants and Resistance Surveillance in China
Data on neonatal GBS disease are very limited in China. Acceptance and implementation of prevention measures such as antibiotics prevention or vaccination against GBS disease would require robust data.
- Trial name
- NCT02812576
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xi'an Jiaotong University
Group B Streptococcus
Safety and Immunogenicity of a Group B Streptococcus Vaccine in Healthy Women
This study will evaluate the safety and immunogenicity of a Group B Streptococcus vaccine.
- Trial name
- NCT01150123
- Testing
- Group B streptococcus (GBS) vaccine- low dose, Group B streptococcus (GBS) vaccine- High dose
- Where
- Belgium
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Immunisation During Pregnancy, Group B Streptococcus
Group B Streptococcus: Attitudes to Immunisation in Pregnancy
Group B Streptococcus (GBS) is the commonest cause of severe infection and meningitis in babies under 3 months in the United Kingdom (UK).
- Trial name
- NCT01982084
- Where
- 4 sites in United Kingdom
- Volunteers
- 758 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Bacterial Infections, Group B Streptococcus
Evaluation of Two Type III GBS Polysaccharide-Tetanus Toxoid Conjugate Vaccines
The purpose of this study is to test the safety and favorable immune response to an anti-streptococcal vaccine (a vaccine that treats a common bacterial infection) in healthy non-pregnant women.
- Trial name
- NCT00008853
- Testing
- GBS III-TT-SSI, GBS III-TT-MPHL
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
GBS Rectovaginal Colonization, Neonatal Sepsis
Probiotics and GBS Colonization in Pregnancy
Multicentric, randomized, placebo-controlled, double-blind, parallel group study aimed at evaluating the feasibility and effect of the use of probiotic starting from the 30th week, on vaginal / rectal colonization of GBS in women…
- Trial name
- NCT05156333
- Testing
- Respecta
- Where
- 3 sites in Italy
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Group B Streptococcus Carrier in Childbirth, Group B Streptococcal Infection, Late-Onset
Serocorrelate of Protection Against GBS (PREPARE WP3)
A multicentre, international case-control study to develop a biobank of sera from 150 cases of serotype III GBS disease and associated clinical information from seven countries (Malawi, Uganda, UK, the Netherlands, Italy and…
- Conditions
- Group B Streptococcus Carrier in Childbirth, Group B Streptococcal Infection, Late-Onset, Group B Streptococcal Infection, Early-Onset, Group B Streptococcus Neonatal Sepsis
- Trial name
- NCT04732026
- Where
- 6 sites in France, Italy and 4 more
- Volunteers
- 600 people
- Sponsor
- St George's, University of London
Group B Streptococcus (GBS) Disease
A Study to Assess the Persistence of Two GBS Antibodies in Women Previously Immunized With a GBS Vaccine
This study looks at the body's immune response to a GBS vaccine 2 years after the orginal vaccine(s) were given in the V98P2 study. Blood will be drawn and evaluated for GBS antibody levels.
- Trial name
- NCT01053767
- Testing
- Group B streptococcus (GBS) vaccine
- Where
- Switzerland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Group B Streptococcal Infections
A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A BOOSTER DOSE OF A GROUP B STREPTOCOCCUS 6 VALENT POLYSACCHARIDE CONJUGATE VACCINE (GBS6) IN HEALTHY ADULTS
This study is an extension to the completed first-in-human C1091001 study (NCT03170609) and is to evaluate the safety and immunogenicity of a single booster vaccine dose of GBS6, administered approximately 2 years or more after a…
- Trial name
- NCT04258995
- Testing
- Group B streptoccous 6-valent polysaccharide conjugate vaccine (GBS6)
- Where
- 4 sites in United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Pfizer
Streptococcus Agalactiae Infection
GBS-NN/NN2 (50 µg of Each Fusion Protein [GBS-NN and GBS-NN2] in Combination With 500 µg Aluminum as Alhydrogel®) Given With and Without the Tdap Vaccine in Healthy Non-pregnant Women 18 to 49 Years of Age
The main objectives of the study are to demonstrate the non-inferiority of the immune response induced by co administered GBS-NN/NN2 and tetanus, diphtheria, and acellular pertussis (Tdap) compared to the separate administration…
- Trial name
- NCT06494475
- Testing
- GBS-NN/NN2 vaccine, Tdap vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Minervax ApS
Group B Streptococcus, Invasive Bacterial Diseases (IBD)
Preparing for Maternal GBS Vaccine Trials in Africa
Infections are one of the key causes of newborn deaths. Among them, Group B Streptococcus (GBS) is the leading cause of sepsis and bacterial meningitis in the first 90 days of life.
- Conditions
- Group B Streptococcus, Invasive Bacterial Diseases (IBD), Maternal Immunization
- Trial name
- PROTECT (NCT06833957)
- Where
- 10 sites in Kenya, Malawi and 2 more
- Volunteers
- 18,100 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Group B Streptococcus Carrier in Childbirth, Gastrointestinal Symptoms
The Efficacy of Probiotics to Reduce Antepartum Group B Streptococcus Colonization.
This study is a randomized double blind, placebo controlled trial to determine the efficacy of an oral probiotic in reducing antenatal Group B Streptococcus colonization.
- Trial name
- NCT03696953
- Testing
- Florajen3
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Marquette University
Pregnancy
Quasi Experiment of Prenatal Probiotics Against Group B Streptococcus Colonization
This pilot quasi experiment was designed to determine the feasibility of a randomized controlled trial of the oral probiotic combination of Florajen3 (>7.5 x109 L. acidophilus, >6.0 x109. B. lactis, and >1.5 x109 B.
- Trial name
- NCT02249325
- Testing
- Probiotic dietary supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marquette University
Invasive Group B Streptococcus Disease
GBS Sero-correlate of Protection
Compare anticapsular antibody levels against Group B Streptococcus at delivery in mothers and their infants who develop disease versus those who do not.
- Trial name
- V98_28OBTP (NCT02215226)
- Where
- South Africa
- Volunteers
- 35,274 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Group B Streptococcus Infection
A Follow up Study of Group B Streptococcus (GBS)-NN/NN2 Vaccine in Healthy Volunteers
The goal of this follow-up study is to investigate the persistence of the immune response induced by the GBS-NN/NN2 vaccine in women who have participated in study MVX0002, and/or in study MVX0003 with GBS-NN/NN2 vaccine and…
- Trial name
- NCT06280157
- Testing
- GBS-NN/NN2
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Minervax ApS
GBS
Effectiveness of Intrapartum Group B Streptococcus (GBS) Polimerase Chain Reaction Reaction (PCR) Screening
Study hypothesis: Intrapartum polimeraze chain reaction (PCR)of group B streptoccocus (GBS) test is more accurate than Culture of GBS at 35-37 weeks gestation for GBS carriage.
- Trial name
- NCT01833780
- Sponsor
- The Baruch Padeh Medical Center, Poriya
GBS Positive, Women in Labor Given Vancomycin for Prophylaxis
Intrapartum Vancomycin for Group B Streptococcus (GBS) Prophylaxis
While it is clear that intrapartum antibiotics reduce neonatal GBS infection rates, the mechanism by which these drugs prevent neonatal GBS is not well established.
- Trial name
- NCT02143154
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Group B Streptococcus
Intrapartum Rapid GBS Testing in Patients Presenting With Threatened Preterm Labor
The purpose of this study is to evaluate the test characteristics of a rapid intrapartum real- time polymerase chain reaction (RT-PCR) compared to the intrapartum GBS culture as the standard in preterm patients presenting with…
- Trial name
- NCT02511444
- Testing
- GBS culture and real time PCR
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- MemorialCare Health System
Group A Streptococcus: B Hemolytic Pharyngitis
Detection of GABHS in Throat Gargle
The objective of this study is to investigate the use of patient throat gargle as an alternative to throat swabbing for the diagnosis of pharyngitis caused by Group A β-Hemolytic Streptococcus (GABHS) infection, also known as…
- Trial name
- NCT03231098
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Gargle Tech