Clinical trials: Graft Failure
Chronic Kidney Failure
Belatacept as a Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction
Calcineurin inhibitors (CNI) remain the standard treatment in renal transplantation to prevent rejection. Currently the main limitation of kidney transplantation is the occurrence of chronic graft dysfunction due to the CNI…
- Trial name
- BELASBRIDGE (NCT05562869)
- Testing
- Belatacept 250 Milligram Intravenous Powder for Solution
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Cardiac Allograft Vasculopathy, Acute Cellular Graft Rejection
Cardiac Mitochondrial Function After Heart Transplantation
Studies have shown that cardiac function is affected immediately after heart transplantation (HTx), but seems to recover to some extent over the first year.
- Conditions
- Cardiac Allograft Vasculopathy, Acute Cellular Graft Rejection, Primary Graft Failure, Mitochondrial Function
- Trial name
- ENERGY-HTX (NCT04105803)
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Transplant;Failure,Kidney, Transplant; Failure, Liver
Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant
Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation?…
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Liver, Adherence, Medication, Adherence, Patient
- Trial name
- NCT05613010
- Testing
- mHealth Messaging Intervention Group
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Johns Hopkins University
Graft Versus Host Disease
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant
This trial will see if extended abatacept administration (combined with a standard regimen of tacrolimus and mycophenolate mofetil) will prevent acute and chronic graft-versus-host disease (GVHD) in children and adolescents…
- Trial name
- ASCENT (NCT03924401)
- Testing
- Abatacept
- Where
- 9 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Renal Fibrosis, Kidney Transplant Failure
Multicenter, Prospective Study for Urinary Exosomal Biomarkers of Kidney Allograft Tubulointerstitial Fibrosis
The investigators aim to identify urinary exosomal biomarkers that represent the extent of graft fibrosis from deceased donor kidney transplantation.
- Trial name
- UFO (NCT03870542)
- Testing
- kidney transplantation
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
End Stage Renal Disease
Goal Directed Fluid Administration for Kidney Transplantation
The goal of the proposed study is to evaluate the efficacy of a goal-directed fluid administration algorithm on early graft function in patients undergoing kidney transplantation.
- Trial name
- NCT02192086
- Testing
- goal directed fluid therapy, Control Group
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Liver Diseases, Surgery
RESTORE Declined Livers Study
This is a prospective, non-randomized, clinical trial of discarded liver transplants that have received normothermic machine perfusion (NMP), compared with standard cold preservation liver transplants.
- Conditions
- Liver Diseases, Surgery, Transplant; Failure, Liver
- Trial name
- NCT04483102
- Testing
- Declined liver in Normothermic Machine Perfusion (NMP), Standard cold preservation of liver
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine
Central Sleep Apneas Syndrome, Heart Failure
PAC-IC-SAS Pilot Study - Central Sleep Apneas Syndrome and Ventricular Function
The aim of this clinical trial is to evaluate the effect of an early treatment of sleep-disordered breathing by adaptive servo-ventilation in heart failure patient following coronary artery bypass graft surgery or other coronary…
- Conditions
- Central Sleep Apneas Syndrome, Heart Failure, Coronary Artery Bypass Graft Surgery or Other Coronary Reperfusion
- Trial name
- NCT01741337
- Testing
- Adaptive servo-ventilation post-operative treatment for 6 months
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Grenoble
End-stage Renal Disease, Kidney Failure, Chronic
Evaluation of the Safety and Efficacy of a Vascular Prosthesis for Hemodialysis Access in Patients With ESRD
The purpose of this study is to assess the safety and efficacy of a novel, tissue-engineered vascular prosthesis, the Human Acellular Vascular Graft, HAVG.
- Trial name
- NCT01744418
- Testing
- HAVG graft implantation
- Where
- 3 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Humacyte, Inc.
Hypospadias
Clinical Trial to Assess the Safety and Efficacy of Investigational Product in Patients Due to Hypospadias Treatment Failure
The purpose of this trial is to assess the safety and efficacy of Holour in patients suffering from hypospadias treatment failure.
- Trial name
- HOLOUR (NCT05093166)
- Testing
- "Ex vivo" expanded autologous human oral epithelium containing stem cells
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Holostem s.r.l.
Acute Graft Versus Host Disease Grade II-IV, Acute Graft vs Host Disease
Study of Gecacitinib in the Treatment of Acute Graft-Versus-Host Disease After Failure of Ruxolitinib-containing Second-line Therapy
An open-label, single-arm clinical trial to evaluate the safety and efficacy of gecacitinib tablets in patients with acute graft-versus-host disease (GVHD) who have failed or are intolerant to ruxolitinib-containing second-line…
- Trial name
- GRIT (NCT07197112)
- Testing
- Gecacitinib
- Volunteers
- 15 people
- Sponsor
- Ruijin Hospital
Blood Stem Cell Transplant Failure, Oral Mucositis
The Effect of Nursing Education on Oral Mucositis in Bone Marrow Transplant Patients
In this study, it is aimed to examine the effect of oral care training for oral mucositis, which will be given by the researcher to patients who have undergone bone marrow transplantation, on the incidence and severity of oral…
- Conditions
- Blood Stem Cell Transplant Failure, Oral Mucositis, Nurse's Role
- Trial name
- NCT05705622
- Testing
- Oral mukositis nurse's education for patients
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
End Stage Renal Disease
The Effect of Oxygen on Healing an Artery From the "Injury" of Surgery
Many grafts placed for dialysis access fail which causes patients to undergo additional operations, decreases their quality of life, and increases health care costs.
- Trial name
- NCT00863603
- Testing
- oxygen
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Minnesota
Liver Failure, End Stage Liver Disease
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Rationale: Recent publications report good results of controlled donation after circulatory death (DCD) Maastricht category III liver transplantation when strict donor-recipient matching is applied and ischemia times are kept to…
- Conditions
- Liver Failure, End Stage Liver Disease, Biliary Tract Diseases
- Trial name
- DHOPE-DCD (NCT02584283)
- Testing
- Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 157 people
- Sponsor
- Robert J. Porte
Chronic Renal Failure (CRF), Graft Failure
Renal Transplantation in the Elderly - nEverOld Study
An exploratory study of the efficacy and safety of a regimen consisted of Everolimus plus low tacrolimus for the immunosuppression in renal transplantation in the elderly.
- Conditions
- Chronic Renal Failure (CRF), Graft Failure, Transplant; Failure, Kidney, Renal Transplant Rejection
- Trial name
- NCT01631058
- Testing
- Everolimus
- Where
- 2 sites in Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Graft-versus-Host Disease
A Trial to Evaluate the Safety and Efficacy of NCR102 in Subjects With aGVHD
Evaluate the safety and efficacy of NCR102 injection in the treatment of SR-aGVHD patients who have failed second-line therapy.
- Trial name
- NCT06941350
- Testing
- NCR102 injection
- Volunteers
- 24 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Heart Failure
Prognosis of Heart Transplanted Patients With Heart Failure
Heart transplantation is the most effective treatment for end-stage heart failure, advanced cardiomyopathy, and complex congenital heart disease with severe heart failure or hypoxia.
- Trial name
- RE-START (NCT05775432)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Interstitial Fibrosis, Kidney Transplant; Complications
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of fingolimod (brand name Gilenya®, candidate name- FTY720) on the background of standard…
- Conditions
- Interstitial Fibrosis, Kidney Transplant; Complications, Kidney Transplant Rejection, Kidney Transplant Failure and Rejection
- Trial name
- NCT05285878
- Testing
- Fingolimod
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Heart Failure Due to Coronary Artery Disease
Optimizing Strategy of Coronary Revascularization in Patients With Multivessel Lesions Combined Heart Failure
As the end stage of almost all cardiovascular diseases, heart failure has become an increasingly common cause of cardiovascular morbidity and mortality worldwide.
- Trial name
- OSCRM-HF (NCT02775578)
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Hybrid Coronary Revascularization
- Where
- China
- Volunteers
- 525 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Kidney Transplant Failure and Rejection, Transplantation, Kidney
To Explore the Application Value of Magnetic Resonance Imaging in Noninvasive Quantitative Evaluation of Graft Function and Systemic Metabolism After Renal Transplantation
At present, renal biopsy is the gold standard for evaluating the pathology of renal transplants, but it is invasive and has the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is…
- Conditions
- Kidney Transplant Failure and Rejection, Transplantation, Kidney, Kidney Transplant Dysfunction
- Trial name
- NCT07145944
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital