Clinical trials: Gonarthrosis; Primary
Osteoarthritis, Knee, Osteoarthritis
A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis
The goal of this clinical study is to evaluate the effectiveness of the properties that support the functional state of the joints and the safety of the dietary supplement for food ARTNEO®, oral capsules, in patients with stage…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Knee Osteoarthritis, Knee Arthritis
- Trial name
- NCT05975879
- Testing
- undenaturated collagen type II, methylsulfonylmethane, boswellia serrata, vitamin D3 (cholecalciferol), vitamin C (ARTNEO)
- Where
- 12 sites in Russia
- Volunteers
- 212 people
- Sponsor
- NPO Petrovax
Osteoarthritis of Knee
Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)
This phase III clinical study will be conducted in Brazilian research sites. It will be included in the study 314 participants diagnosed with primary knee OA according to the classification criteria of the ACR.
- Trial name
- GLACIAL (NCT02830919)
- Testing
- Glucosamine and chondroitin sulfate combination (Eurofarma), Glucosamine and chondroitin sulfate combination (Zodic)
- Where
- 4 sites in Brazil
- Volunteers
- 627 people
- Sponsor
- Eurofarma Laboratorios S.A.
Osteo Arthritis Knee, Total Knee Replacement
LEGION™ Primary Safety and Efficacy
This study will look at the health results of using the LEGION™ Primary Knee System over a period of ten (10) years. This type of surgery uses an artificial knee made of plastic and metal.
- Trial name
- NCT04040985
- Testing
- Total Knee Arthroplasty using LEGION™ Total Knee System
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee, Osteoarthritis, Hip
Phase II Study of CG100649 for Primary Osteoarthritis in Male Subjects
The primary objective of this study is to evaluate the safety and efficacy of 3 loading and maintenance dose levels of CG100649 administered for 21 days in the treatment of osteoarthritis pain.
- Trial name
- NCT00530452
- Testing
- CG100649, Silicified microcrystalline cellulose + talc
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- CrystalGenomics, Inc.
Knee Osteoarthritis
Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee Replacement
Osteoarthritis (OA) is one of the most common diseases affecting the joints, usually those that are weight bearing such as the knees.
- Trial name
- NCT00911469
- Testing
- AS902330
- Where
- 19 sites in Bulgaria, Denmark and 4 more
- Volunteers
- 73 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Knee Arthroplasty, Total, Robotic Surgical Procedures
ROSA® Knee System V1.5 Pilot Study
This pilot study seeks to evaluate the initial safety and usability of new features for the ROSA® Knee System, v1.5 and plan design modifications as needed. The primary objectives will be assessed by measuring: 1.
- Conditions
- Knee Arthroplasty, Total, Robotic Surgical Procedures, Joint Diseases, Knee Osteoarthritis
- Trial name
- NCT07009912
- Testing
- Total Knee Arthroplasty
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS
The purpose of this study is to determine whether intra-articular (knee joint) administration of MEN16132 is effective reducing the pain from knee osteoarthritis.
- Trial name
- ALBATROSS (NCT01091116)
- Testing
- MEN16132 - 0.125 mg, MEN16132 - 0.25 mg, MEN16132 - 0.5 mg
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 423 people
- Sponsor
- Menarini Group
Total Knee Arthroplasty
Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis
The life expectancy worldwide is increasing and leading to an increase of knee arthroplasty. Also, as millions of people around the world are currently living with a Total Knee Arthroplasty (TKA), the need for revision surgery…
- Trial name
- FHK-CK (NCT06124482)
- Testing
- Total Knee arthroplasty
- Where
- 7 sites in France
- Volunteers
- 92 people
- Sponsor
- FH ORTHO
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Establish Implant Accuracy With X-PSI Knee System
The goal of this study is to establish the accuracy of the new X-PSI Knee System guides by analyzing early postoperative (4-6 weeks) imaging data with regards to the mechanical alignment and compare them with preoperative…
- Trial name
- X-PSI (NCT03275246)
- Testing
- X-PSI Knee System
- Where
- 4 sites in Germany, Netherlands and 1 more
- Volunteers
- 8 people
- Sponsor
- Zimmer, GmbH
Knee Osteoarthritis
A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study
A multicenter, randomized, double-blind, parallel-group, placebo-controlled, and active-drug, 12-week, multicenter clinical study.
- Trial name
- SAVE (NCT03936192)
- Testing
- glucosamine sulphate 1500mg and meloxicam 15mg, Glucosamine sulfate 1500mg and chondroitin sulfate 1200mg
- Sponsor
- Eurofarma Laboratorios S.A.
Osteoarthritis, Knee
Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis
Matrix metalloproteinases (MMPs) have been implicated in the cartilage degradation. PG-530742 inhibits some MMPs, potentially limiting cartilage degradation and disease progression.
- Trial name
- NCT00041756
- Testing
- PG-530742, 50 mg PG-530742, 100 mg PG-530742
- Where
- 23 sites in Hungary, United Kingdom
- Volunteers
- 395 people
- Sponsor
- Procter and Gamble
Osteoarthritis of the Knee
MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty
Overall study design: A prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the Genesis II total knee system.
- Trial name
- MIS GEN II (NCT00853398)
- Testing
- surgical technique
- Where
- Germany
- Sponsor
- Smith & Nephew Orthopaedics AG
Localized Primary Osteoarthritis of Hip, Localized Primary Osteoarthritis of Knee
Phase III Study of CG100649 in Osteoarthritis Patients
6-week Efficacy Study The objective of this study is to prove the safety and non-inferiority of analgesic efficacy of CG100649 2 mg vs. celecoxib 200 mg, and analgesic superiority of CG100649 2 mg vs.
- Trial name
- NCT01765296
- Testing
- CG100649, Celecoxib
- Where
- 14 sites in South Korea
- Volunteers
- 362 people
- Sponsor
- CrystalGenomics, Inc.
Primary Knee Osteoarthritis Grade 3 - 4
LIKEST Study: Lipocet® in Adults With Primary Knee Osteoarthritis Grade 3-4
The purpose of this study is to assess the safety, tolerability and efficacy of Lipocet® (food supplement) in patients with primary knee osteoarthritis grade 3 - 4
- Trial name
- NCT06134115
- Testing
- Lipocet® (food supplement)
- Where
- 3 sites in Georgia
- Volunteers
- 60 people
- Sponsor
- Pharmanutra S.p.a.
Osteoarthritis of the Knee
A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee
The primary purpose of the study is to evaluate the change from baseline after 4 weeks of topical administration of TV-45070 (4% and 8% ointment) compared with placebo for the relief of symptoms of primary OA affecting a single…
- Trial name
- NCT02068599
- Testing
- TV-45070
- Where
- 42 sites in United States
- Volunteers
- 389 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Osteoarthritis, Knee
Efficacy and Safety of Lumiracoxib in Patients With Knee Osteoarthritis (OA).
This study will investigate the efficacy and safety of lumiracoxib in patients with primary knee osteoarthritis (OA).
- Trial name
- NCT00366938
- Testing
- Lumiracoxib
- Where
- United States
- Volunteers
- 1,464 people
- Sponsor
- Novartis
Knee Osteoarthritis
Evaluation of Safety and Efficacy of ReHub in Patients Who Underwent Primary Total Knee Arthroplasty
This is a randomized, non-blinded, parallel assignment, clinical trial for the evaluation of safety and efficacy of ReHub, a telerehabilitation system made up of a cloud platform and an exercise kit with smart sensors, for…
- Trial name
- REHAPT (NCT04155957)
- Testing
- Rapid Recovery Rehabilitation Programme, ReHub
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Bio-Sensing Solutions S.L. (DyCare)
Knee Osteoarthritis
Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis
To evaluate the clinical efficacy and safety of dental pulp mesenchymal stem cells in the treatment of primary mild to moderate knee osteoarthritis through a comparative study with sodium hyaluronate.
- Trial name
- NCT04130100
- Testing
- Low Dose of Mesenchymal stem cell, High Dose of Mesenchymal stem cell, Sodium Hyaluronate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- CAR-T (Shanghai) Biotechnology Co., Ltd.
Primary Knee Osteoarthritis
Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis
This is a multicenter, randomized, double-blind, placebo-controlled, Phase IIb study to evaluate intra-articular (IA) injections of Allocetra in participants with moderate-to-severe age related symptomatic primary knee…
- Trial name
- NCT07580716
- Testing
- Allocetra
- Where
- 17 sites in United States, Denmark and 1 more
- Volunteers
- 182 people
- Sponsor
- Enlivex Therapeutics Ltd.
Osteoarthritis, Knee
A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2 trial of Sprifermin administered intra-articularly in participants with primary osteoarthritis of the knee and Kellgren-Lawrence Grade 2…
- Trial name
- FORWARD (NCT01919164)
- Testing
- Sprifermin
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 549 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.