Clinical trials: Goal Directed Fluid Therapy
Goal Directed Fluid Therapy
Stroke Volume Variation and Plethysmography Variability Index as Goal Directed Fluid Therapy in Major Oncosurgeries
Patients were allotted to two Groups , SVV Guided Fluid Therapy Group received intraoperative fluids to maintain SVV <11 , and PVI Guided Group received intraoperative Fluids to maintain PVI<11
- Trial name
- SVV PVI GDFT (NCT05142163)
- Testing
- Intraoperative SVV Guided Fluid Therapy, Intraoperative PVI Guided Fluid Therapy
- Where
- India
- Volunteers
- 68 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Surgery-Complications
Restrictive- vs Individualized Goal Directed Fluid Therapy in Liver Surgery
"Low central venous pressure (low-CVP) or a restrictive fluid administration strategy is usually used worldwide during major liver resection surgery.
- Trial name
- REVOLUTION (NCT05704387)
- Testing
- individualized GDFT, Restrictive fluid therapy strategy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock
To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.
- Trial name
- NCT02060773
- Where
- China
- Sponsor
- Zhongda Hospital
Goal-directed Fluid Therapy
Goal Directed Fluid Therapy Guided Fluid Management in Pneumoresection
Perioperative fluid management is a key component of anesthetic management during thoracic surgery. On one hand, fluid restriction could compromise perfusion of vital organs and surgical anastomosis.
- Trial name
- NCT03237351
- Testing
- Fluid therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ZhiHeng Liu
Septic Shock
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT03080038)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- 8 sites in Canada
- Volunteers
- 406 people
- Sponsor
- McMaster University
Bone Tumor, Acute Normovolemic Hemodilution
A Substudy of the Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of perioperative anemia has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone tumor surgery.
- Conditions
- Bone Tumor, Acute Normovolemic Hemodilution, Goal-Directed Fluid Therapy
- Trial name
- NCT06881498
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
ERAS, Colorectal Surgery
Epidural Analgesia and Intraoperative Fluid Management in Colorectal Surgery
The Enhanced Recovery After Surgery (ERAS) protocols have demonstrated their efficacy in expediting recovery and minimizing postoperative complications, especially in patients undergoing abdominal surgery.
- Conditions
- ERAS, Colorectal Surgery, Goal-directed Fluid Therapy, Conventional Fluid Therapy
- Trial name
- NCT06810648
- Testing
- GDFT, GDFT/ED, CFT
- Where
- 2 sites in Greece
- Volunteers
- 121 people
- Sponsor
- University of Ioannina
Perioperative/Postoperative Complications, Hypovolemia
Goal-directed Therapy in High-risk Surgery
There is growing evidence that the risk of postoperative complications can be decreased by optimizing the amount and type of infusion fluids given during surgery, steered by goal-directed therapy based on flow-related hemodynamic…
- Conditions
- Perioperative/Postoperative Complications, Hypovolemia, Hypoxia
- Trial name
- NCT01681238
- Testing
- Protocol group 2, Protocol group 1
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangzhou First People's Hospital
Postoperative Complications
GDFT on the Postoperative Outcome in Head and Neck Cancer Surgery
The goal of this clinical trial is to evaluate whether goal-directed fluid therapy (GDFT) can improve the postoperative recovery in patients undergoing head and neck cancer surgery.
- Trial name
- NCT06468852
- Testing
- Goal-Directed Fluid Therapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Beijing Tongren Hospital
Therapy Adverse Effect
Preoperative Goal-directed Fluid Therapy and Physiological Changes Following One-lung Ventilation
Intraoperative goal-directed fluid therapy (GDFT) is proposed to improve the outcomes of patients undergoing major surgery. In the GDFT algorithm, the employment of fluid bolus plays a crucial role.
- Trial name
- NCT03064880
- Testing
- SV maximization
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Perioperative Tissue Oxygenation
Improving Tissue Oxygenation in Breast Reconstruction Surgery
Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue).
- Trial name
- NCT04020172
- Testing
- Dobutamine
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD)
Ventilator Lung, Liver Cirrhosis
Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection.
- Conditions
- Ventilator Lung, Liver Cirrhosis, Hepatocellular Carcinoma, Blood Loss, Surgical
- Trial name
- NCT05490147
- Testing
- conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group, low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Esophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)
Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients
Brief Summary This clinical trial aims to evaluate whether perioperative goal-directed fluid therapy (GDFT) targeting a venous excess ultrasound (VExUS) score of 1 can reduce postoperative pulmonary complications (PPCs) in…
- Trial name
- NCT07691944
- Testing
- VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
- Volunteers
- 126 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Prostate Cancer, Robotic Radical Prostatectomy
Hemodynamic Monitoring-Guided Goal-Directed Fluid Therapy in Robotic Radical Prostatectomy
This prospective observational cohort study evaluated goal-directed fluid therapy guided by minimally invasive hemodynamic monitoring in adult male patients undergoing elective robotic radical prostatectomy.
- Trial name
- NCT07806539
- Testing
- LiDCO-guided goal-directed fluid therapy, Conventional fluid therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Antalya Training and Research Hospital
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Fluid Therapy, Brain Edema
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain.
- Conditions
- Fluid Therapy, Brain Edema, Brain Tumor
- Trial name
- NCT03323580
- Testing
- GDFT, traditional fluid therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Tiantan Hospital
Femoral Fracture
Goal Directed Haemodynamic Treatment for Patients With Proximal Femoral Fracture
The investigators aimed to compare the costs and consequences of 'routine perioperative fluid therapy' and 'GDHT in terms of morbidity, mortality, length of hospital stay, activity of daily living, health related quality of life…
- Trial name
- GDHT (NCT01141894)
- Testing
- Goal directed haemodynamic treatment, Routine fluid treatment
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Fluid Therapy
The Effect of Goal-directed Therapy Guided by Stroke Volume Variation and Cardiac Index in Non-severe Surgical Patients
To evaluate the application of fluid-infusion therapy with the combination of stroke volume variation (SVV) and cardiac index (CI) as the primary judgment in non-severe patients underwent resection of gastrointestinal tumor.
- Trial name
- NCT02841046
- Testing
- cardiac index, Stroke Volume Variation
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Major Abdominal Surgery, Duodenohemipancreatectomy
Intraoperative Haemodynamic Optimization Comparing Flow and Pressure Parameters
The purpose of the study is to confirm the hypothesis that flow treatment algorithm based on cardiac index trending by transesophageal Dopplerometry would result in reduced complications and reduced length of hospital stay in…
- Conditions
- Major Abdominal Surgery, Duodenohemipancreatectomy, Rectal Resection, Extensive Bowel Surgery
- Trial name
- Flow-press (NCT02104687)
- Testing
- Flow group, Press group
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Acute Abdomen, Abdominal Trauma
Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Emergency Laparotomy
The goal of this clinical trial is to test the safety and effectiveness of the ERAS protocols compared to a conventional care protocols in patients who received emergency laparotomy.
- Conditions
- Acute Abdomen, Abdominal Trauma, Emergency Surgery
- Trial name
- ERAS (NCT06182488)
- Testing
- ERAS protocols, Conventional protocols
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University