Clinical trials: Glycemic Control
Type 2 Diabetes Mellitus
Trial to Evaluate the Efficacy and Safety of Gemigliptin Compared With Placebo Added on Insulin Alone or on Insulin in Combination With Metformin in Type 2 DM (ZEUS II Study)
The objective of this study is to evaluate the efficacy and safety of gemigliptin 50 mg orally administered once daily for 24 weeks compared with placebo in patients with type 2 diabetes mellitus who have inadequate glycemic…
- Trial name
- NCT02831361
- Testing
- Gemigliptin, Metformin, Diet/exercise questionnaire
- Volunteers
- 290 people
- Sponsor
- LG Life Sciences
Diabetes Mellitus, Type 2
The CANTATA-MSU Trial (CANagliflozin Treatment And Trial Analysis - Metformin and SUlphonylurea)
The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in patients with type 2 diabetes mellitus who are receiving treatment with metformin and sulphonylurea…
- Trial name
- NCT01106625
- Testing
- Canagliflozin, Metformin, Sulphonylruea
- Where
- 76 sites in United States, Australia and 10 more
- Volunteers
- 469 people
- Sponsor
- Janssen Research & Development, LLC
Type 2 Diabetes
Low Glycemic Index Diet for Type 2 Diabetics
A low glycemic index diet may improve glycemic control and reduce plaque buildup in arteries of those with type 2 diabetes. Subjects will be randomly assigned to receive dietary advice on either a low glycemic index diet, or a…
- Trial name
- NCT01063374
- Testing
- low glycemic diet instruction, high cereal fibre diet instruction
- Where
- 2 sites in Canada
- Volunteers
- 169 people
- Sponsor
- University of Toronto
Critical Illness, Hyperglycemia
Comparing Two Ways of Controlling Blood Sugar With Insulin in Patients Admitted to the Intensive Care Unit
The purpose of this study is to determine if there is any difference between two ways of controlling blood sugar with insulin. In patients admitted to the intensive care unit, blood sugar levels often rise due to the stress of…
- Trial name
- NCT00166491
- Testing
- Insulin
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 1
Insulin Delivery Using the DBLG1 Closed-loop on Glycemic Control and PROMs in Adults Living With Type 1 Diabetes
To evaluate the impact of the DBLG1 hybrid closed-loop system on glycemic control and patient-reported outcomes in adults living with type 1 diabetes under real-life conditions.
- Trial name
- INLOOP (NCT06154135)
- Where
- 12 sites in Belgium
- Volunteers
- 165 people
- Sponsor
- Erasme University Hospital
T2DM (Type 2 Diabetes Mellitus)
Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control
The main objective of this study is to compare the efficacy and safety of the triple combination therapy of Met/SGLT-2i/GLP-1RA or other oral antidiabetic drugs in patients with type 2 diabetes exhibiting poor glycemic control.
- Trial name
- MESSAGE (NCT07244003)
- Testing
- Metformin, Triple Therapy of Other Oral Antidiabetic Drugs, ganagliflozin
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Gestational Diabetes
Effects of Probiotics on Gut Microbiota Composition and Metabolic Outcomes in Post- Gestational Diabetes Women
Risk of developing diabetes at a younger age among women with a previous history of gestational diabetes mellitus (post-GDM) has increased by 10-fold compared to the healthy women.
- Trial name
- NCT05273073
- Testing
- Probiotics
- Where
- Malaysia
- Volunteers
- 166 people
- Sponsor
- National University of Malaysia
Diabetes Mellitus, Type 2
Comparing Pre-Mixed Insulin With Insulin Glargine Combined With Rapid-Acting Insulin in Patients With Type 2 Diabetes
The purpose of this study is to compare Lispro Mixture Therapy (insulin lispro 50/50 given three times daily with meals) to Glargine Basal-Bolus Therapy (insulin glargine daily with the addition of insulin lispro given three…
- Trial name
- NCT00110370
- Testing
- Lispro Mixture Therapy, Glargine Basal-Bolus Therapy
- Where
- 48 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2
GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
The purpose of this study is to compare the benefits and risks of lixisenatide (AVE0010) in comparison to exenatide (Byetta®), as an add-on treatment to metformin, over a period of 24 weeks of treatment, followed by an extension.
- Trial name
- GETGOAL-X (NCT00707031)
- Testing
- Lixisenatide (AVE0010), Pen auto-injector, Exenatide
- Where
- 18 sites in United States, Argentina and 16 more
- Volunteers
- 639 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
Fasiglifam 25 mg BID vs 50 mg QD
To evaluate the efficacy of fasiglifam 25 mg twice daily (BID) and fasiglifam 50 mg once daily (QD) on glycemic control in adults with type 2 diabetes who are inadequately controlled on diet and exercise alone.
- Trial name
- NCT01982253
- Testing
- Fasiglifam
- Where
- 88 sites in United States, Bulgaria and 5 more
- Volunteers
- 10 people
- Sponsor
- Takeda
Intraoperative Complications
Intravenous Bolus-infusion Versus Sliding Scale of Insulin for Intra-operative Glycemic Control
Pre-operative blood glucose (BG) concentrations in type 2 diabetic patients undergoing elective non-cardiac surgery; have an increased incidence of in-hospital morbidity for cardiopulmonary and infectious complications.
- Trial name
- NCT05136157
- Testing
- Rapid-Acting Insulin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Type 2 Diabetes Mellitus
A Clinical Study to Evaluate the Effects of Enicepatide Versus Tirzepatide in Participants With Type 2 Diabetes and Inadequate Blood Sugar Control on Oral Glucose-Lowering Medications
The study will evaluate the efficacy and safety of enicepatide, a glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor (GLP-1/GIP) receptor agonist (RA), compared with tirzepatide among participants with…
- Trial name
- ENI-SPIRE-2 (NCT07889648)
- Testing
- Enicepatide, Tirzepatide
- Volunteers
- 948 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Type 1
The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM
The investigators intends to carry out a randomized, cross-over, prospective study which will last 48 weeks in youth with T1DM followed up by the center.
- Trial name
- NCT02765347
- Testing
- Metformin, Insulin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes
A Trial of Three- and Seven-days Insulin Infusions Set
More and more children and adolescents are using diabetes devices attached to the skin. The attachment of infusions sets to the skin provoke allergenic or toxic eczema, the continous infusion of insulin provoke subcutaneous…
- Trial name
- NCT06532461
- Testing
- Mio Advanced infusions set, Novorapid, Extended wear insulin infusion (EWIS)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes
Durability of Combination of Insulin and GLP-1 Receptor Agonist or SGLT-2 Inhibitors Versus Basal Bolus Insulin Regimen in Type 2 Diabetes (BEYOND)
BEYOND represents an open-label, parallel, three-arm randomized controlled trial, aimed at evaluating the effects of combination therapy of fixed ratio basal insulin/GLP-1 receptor agonist (GLP-1RA) or basal insulin/SGLT-2…
- Trial name
- BEYOND (NCT04196231)
- Testing
- IDegLira, IGlarLixi, Insulin/Canaglifozin
- Where
- Italy
- Volunteers
- 258 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type 2 Diabetes Mellitus
Value of Glycated Albumin in Intervention of Glycemic Control in Chinese Patients With Type 2 Diabetes
HbA1c is widely used as the gold standard for evaluating glycemic control. However, in patients who need adjusting hypoglycemic regimen, A1c was not a sensitive marker.
- Trial name
- NCT05227677
- Testing
- GA guided anti-diabetic therapy adjustment, current guidelines to adjust treatment
- Where
- 7 sites in China
- Volunteers
- 200 people
- Sponsor
- Asahi Kasei Therapeutics Corporation
Gestational Diabetes Mellitus
MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study
MAIN STUDY: Low glycaemic index (GI) diets are recommended by the Canadian Diabetes Association for treating type 1 and 2 diabetes mellitus (DM), but the role of GI in the management of gestational diabetes(GDM)is not yet clear.
- Trial name
- GIinGDM (NCT01589757)
- Testing
- Standard Care, Low GI diet
- Where
- 4 sites in Canada
- Volunteers
- 99 people
- Sponsor
- University of Toronto
Type 2 Diabetes
Low Glycemic Index Diets (With Pulses) in Type 2 Diabetes
Healthy individuals with type 2 diabetes will receive intensive counseling on food selection to improve glucose control using either high cereal fiber dietary strategies or low glycemic index foods emphasizing dried legumes and…
- Trial name
- NCT01063361
- Testing
- Low glycemic index diet with pulses, High Cereal Fibre
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- University of Toronto
Diabetes Mellitus
Impact of Pantoprazole on 24-H Glycemic Control and on Post-prandial Glucose Excursion in Patients With Type 2 Diabetes
The purpose of this study is to demonstrate the immediate impact of pantoprazole on 24-H glycemic control and on post-prandial glucose excursion in patients with type 2 diabetes.If our data support the previous animal…
- Trial name
- NCT02345239
- Testing
- Pantoprazole
- Volunteers
- 14 people
- Sponsor
- Dr. Waheed Rehman
Diabetes Mellitus
Efficacy of Pioglitazone and Fortamet Combination Therapy in Subjects With Type 2 Diabetes
The purpose of this study is to determine the efficacy of pioglitazone and metformin combination therapy, once daily (QD), on glycosylated hemoglobin in adults with type 2 diabetes.
- Trial name
- NCT00754403
- Testing
- Pioglitazone and metformin, Metformin
- Volunteers
- 312 people
- Sponsor
- Takeda