Clinical trials: Glaucoma; Drugs
Effect of Drug
Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.
It is a randomised, double-blinded clinical trial in which consenting participants who meet the inclusion criteria would be randomised into 2 groups.
- Trial name
- NCT05606796
- Testing
- Latanoprost 0.005% Ophthalmic Solution
- Where
- Nigeria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uzoma Chinyei Joan
Ocular Surface Disease
Amelioration of Adverse Ocular Side Effects of Glaucoma Medications in Glaucoma Patients Using Topical GL101
To evaluate the safety and efficacy of 0.5% GL101 topical gel administered twice daily for 28 days in ameliorating adverse ocular side effects in patients under ongoing treatment with glaucoma medications.
- Trial name
- NCT02656394
- Testing
- GL101
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Glia, LLC
Primary Open Angle Glaucoma (POAG)
One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects
The purpose of this study is to evaluate the safety and efficacy of the intraocular pressure (IOP) lowering effect of one, two, or three iStent devices in eyes of subjects previously on two anti-glaucoma medications.
- Trial name
- NCT01517477
- Testing
- iStent
- Where
- Armenia
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Primary Open Angle Glaucoma, Drug Effect
Effect of Ginkgo Biloba Capsule on Visual Function of Primary Open-angle Glaucoma With Blood Stasis Syndrome
Primary Open Angle Glaucoma (POAG) is an eye disease that causes optic nerve damage, visual field defect, and blindness caused by increased intraocular pressure.
- Trial name
- NCT04334564
- Testing
- Ginkgo biloba capsule
- Where
- China
- Volunteers
- 512 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma
Efficacy of Glaucoma Drop Aids in Medication Compliance in the Patient Population at Boston Medical Center
The purpose of this study is to determine whether glaucoma drop aids will be cost-effective in delivery of ophthalmic medications by improving medication compliance, visual function, and even decreasing medication waste in the…
- Trial name
- NCT02867995
- Testing
- Eye Drop Aid
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Boston Medical Center
Open Angle Glaucoma, Ocular Hypertension
A Phase III Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension in China
This is a Phase III Study that includes a single arm, open-label, multi-dose PK study cohort and a randomized, evaluator-masked, active drug-control multicenter study.
- Trial name
- NCT06666855
- Testing
- DE-117B Eye Drops, Latanoprost
- Where
- 24 sites in China
- Volunteers
- 345 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Medication Adherence, Glaucoma
The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program
The purpose of this research study is to test the impact of two personalized technology based programs that may help improve adherence to glaucoma medications.
- Trial name
- eyeGuide (NCT03159247)
- Testing
- eyeGuide
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Michigan
Glaucoma, Ocular Hypertension
Survey of Patients Taking IOP-Lowering Eye Drops
Survey to assess perspectives of patients prescribed IOP-lowering eye drops at a single office visit.
- Trial name
- NCT02384772
- Testing
- Survey
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- ForSight Vision5, Inc.
Glaucoma, Ocular Hypertension
Continuous Intraocular Pressure (IOP) Measurement and Ability to Detect Treatment Effect
Continuous intraocular pressure (IOP) measurement with a contact lens sensor may provide more information on the drug-related IOP change than 24-hour IOP measurement with Goldmann applanation tonometry (GAT.
- Trial name
- NCT01491867
- Testing
- travoprost 0.003%
- Where
- 2 sites in Hungary
- Volunteers
- 9 people
- Sponsor
- Semmelweis University
Open Angle Glaucoma
Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication
This study objective is to evaluate the intraocular pressure (IOP) lowering effect of two trabecular micro-bypass stents (iStent inject) in eyes of subjects with primary open-angle glaucoma on one topical hypotensive medication
- Trial name
- NCT02868190
- Testing
- Two trabecular micro-bypass stents (iStent inject)
- Where
- Armenia
- Volunteers
- 57 people
- Sponsor
- Glaukos Corporation
Glaucoma
Novel Drug Delivery Technique Via Retroject Device
The purpose of this study is to identify whether or not injection of a study drug (ethacrynic acid) using the investigational Retroject device is able to lower eye pressures in patients with advanced glaucoma.
- Trial name
- NCT02051946
- Testing
- Retroject Device, ethacrynic acid injection, balanced salt solution
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Molly Walsh
Dry Eye Disease
Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®
The purpose of this study is to determine if there is a difference in the ocular signs and symptoms of subjects' eyes using Xalatan® 0.005% versus Travatan Z® 0.004% based on the outcome of subject assessment and clinical…
- Trial name
- NCT00799682
- Testing
- Xalatan, Travatan Z
- Where
- 5 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Glaucoma; Drugs
Evaluation of Adherence to Clinical Treatment of Glaucoma
Evaluation of adherence to clinical treatment of glaucoma in patients of a Reference Ophthalmological Hospital in Goiânia using Morisky Adhesion scale as a validated questionary.
- Trial name
- NCT03338088
- Where
- 2 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto de Olhos de Goiania
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Glaucoma; Drugs, Normal Tension Glaucoma
Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension…
- Conditions
- Glaucoma; Drugs, Normal Tension Glaucoma, Primary Open-angle Glaucoma
- Trial name
- NCT03323164
- Testing
- Timolol Maleate, Brimonidine Tartrate
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wills Eye
Glaucoma
This Study Examines Whether Personality Traits Influence the Frequency or Severity of Ocular Adverse Effects Reported by Patients Using Glaucoma Medications. The Findings May Identify Patients at Greater Risk of Intolerance and Support More Personalized Treatment and Counselling.
The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.
- Trial name
- Adverse Events (NCT07739784)
- Testing
- No Interventions
- Where
- Canada
- Volunteers
- 352 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Glaucoma, Trabeculectomy
Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes
Antiglaucoma medication have been shown to induce subclinical conjunctival inflammation in a considerable proportion of glaucoma patients.
- Conditions
- Glaucoma, Trabeculectomy, Fibrosis, Intraocular Pressure
- Trial name
- NCT00707421
- Testing
- ketorolac acetate, fluorometholone, artificial lacrimal tears
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma; Drugs
CATS Tonometer IOP Reduction Latanoprost Verses Timolol
Topical Prostaglandin Analog vs Betablocker - Corneal Biomechanical Evaluation using CATS Tonometer Prism
- Trial name
- NCT04178863
- Testing
- CATS Tonometer, Latanoprost
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Intuor Technologies, Inc.
Glaucoma
Observational Study of How Patients Take Eye Drops
This study is interested in monitoring how patients take eye drops, both through video-recordings and adherence monitoring, as well as their perceptions about their eye medications; including the dosing schedules, instillation…
- Trial name
- NCT00750646
- Testing
- MEMS cap
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Glaucoma, Neovascular
Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied
The researchers in this trial want to learn how the drug aflibercept works in in Japanese patients with increased eye pressure that is caused by new blood vessels growing in the eye (neovascular glaucoma or NVG).
- Trial name
- VENERA (NCT03639675)
- Testing
- Aflibercept (EYLEA, BAY86-5321), Topical IOP-lowering drugs
- Where
- 7 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Bayer