Clinical trials: Gingival Inflammation, open to volunteers
Periodontal Diseases, Gingivitis
Diagnostic Accuracy of Oral Images, OPGs, and Questionnaires vs. Clinical Assessment for Periodontal Disease
This is a multi-center, cross-sectional diagnostic study aimed at evaluating the accuracy of various non-invasive methods-including self-reported questionnaires, intra-oral photographs, smartphone images, intraoral scans (IOS)…
- Conditions
- Periodontal Diseases, Gingivitis, Periodontitis
- Trial name
- NCT07164573
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Dental Caries, Gingivitis
Parental Perception of Oral Health-Related Quality of Life in Sudanese Refugee vs. Egyptian Children
This cross-sectional analytical study aims to assess and compare parental perceptions of oral health-related quality of life (OHRQoL) among Sudanese refugee children and Egyptian children aged 6-12 years living in Egypt.
- Conditions
- Dental Caries, Gingivitis, Oral Health, Refugee Health
- Trial name
- NCT07011381
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Gingivitis
Clinical Study Examining the Control of Plaque and Gingivitis
The objective of this six-month clinical investigation is to evaluate the efficacy of a silica-free meridol toothpaste versus Colgate Cavity Protection Toothpaste in the control of established dental plaque and gingivitis.
- Trial name
- NCT07842978
- Testing
- Silica Free Meridol, Meridol, Colgate Dental Product
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontal Diseases, Gingival Diseases
Novel Dental Gel as an Adjunct to Scaling and Root Planing
This study will evaluate the use of Livionex Dental Gel (LDG) as a home care product in reducing probing pocket depth (PD) beyond the effect achieved by the current standard of care with SRP in periodontitis patients.
- Conditions
- Periodontal Diseases, Gingival Diseases, Gingival Pocket, Gum Bleed
- Trial name
- NCT05384132
- Testing
- SRP + Livfresh Dental Gel, SRP + standard flouride dentifrice
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Periodontitis, Gingivitis
Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control
The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : improved dental health reduced risk of pneumonia better glucose…
- Conditions
- Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections
- Trial name
- NHOralHealth (NCT06890676)
- Testing
- Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Missouri Department of Health and Senior Services
Pregnancy, Periodontal Disease
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women…
- Conditions
- Pregnancy, Periodontal Disease, Gingivitis, Dental Plaque
- Trial name
- PREG-Q10 (NCT07029360)
- Testing
- Limosilactobacillus reuteri Prodentis®, Coenzyme Q10 Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Microbiome, Cytokines
Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolerance in People With Gingivitis
This study is a six-week, double-blind, randomized, parallel-group controlled clinical study. The objective of this study is to evaluate the changes to the oral microbiome, inflammatory mediators, gingival health indices and to…
- Conditions
- Microbiome, Cytokines, Plaque, Gingivitis
- Trial name
- NCT07501455
- Testing
- Distilled Water, Marketed Comparator 1, Marketed Comparator 2
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Dental Caries, Gingival Inflammation
DETERMINATION OF THE EFFECTS OF STAINLESS STEEL CROWNS CEMENTED WITH RESIN CEMENTS ON INTERLEUKIN-10, 12, 18 LEVELS IN GINGIVAL CREVICULAR FLUID
This split-mouth clinical study aimed to evaluate the early effects of stainless steel crowns cemented with self-adhesive resin cement and high-viscosity glass ionomer cement on clinical periodontal parameters and interleukin-10…
- Conditions
- Dental Caries, Gingival Inflammation, Periodontal Response to Dental Restorative Materials
- Trial name
- SSC-CYTO (NCT07421206)
- Testing
- Self-Adhesive Resin Cement Group, High-Viscosity Glass Ionomer Cement
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Gingivitis, Periodontitis
Application of Ultra-high Frequency Ultrasonography (UHFUS) to the Study of Gingival Tissues
Gingival inflammation triggered by the accumulation of bacterial is the primary risk factor for the development of periodontitis.
- Trial name
- NCT06480825
- Testing
- Performance of ultrasonographic scan
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Gingivitis
Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for Gingivitis
The goal of this clinical trial is to learn if daily oil pulling with coconut oil or sesame oil works as effectively as a standard mouthwash to treat gum swelling and redness (gingivitis) in adults aged 18 to 55 years.
- Trial name
- NCT07892235
- Testing
- coconut oil, Sesame Oil, 0.2% Chlorhexidine Mouthwash
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Bahria University
Pregnant Woman
Pregnancy Women and Individual Oral Prophylaxis in the Control of Gingival Inflammation (PRE-IOP)
Gingivitis in pregnant women is a common inflammatory periodontal disease that appears from the third month of pregnancy with an overall prevalence of 35 to 100%.
- Trial name
- PRE-IOP (NCT05945225)
- Testing
- Sonicare DiamondClean 9000 Philips®, HydroSonic Easy Curaden®, Manual toothbrush Oral-B 123
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Claude Bernard University
Inflammation Gum, White Spot Lesion
Air-polishing With Erythritol During Orthodontic Tretament
Patients with multi-bracketed fixed orthodontic treatment are at increased risk of developing white spot lesions (WSL) and gingivitis. Various preventive strategies have been examined to prevent the development of WSLs.
- Trial name
- AirPort (NCT05989750)
- Testing
- Ultrasonic scaler, Air-Flow Prophylaxis Master
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Catherine Giannopoulou
Periodontitis
Gas6 and Soluble MerTK in Periodontal Diseases
This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease.
- Trial name
- NCT07535177
- Testing
- gingival crevicular fluid collection
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Cardiac Arrest, Inflammation
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after…
- Conditions
- Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)
- Trial name
- PCAS (NCT02664831)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Periodontal Diseases, Periodontitis
Evaluation of the Effects of Probiotic Toothpastes on Periodontal Health
This controlled, randomized clinical study aims to evaluate the possible effects of probiotic toothpaste on the success of periodontal treatment in smokers and non-smokers with clinical data.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT06514664
- Testing
- Using Probiotic Toothpaste
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Peri Implant Mucositis
Effect of Water Flossing on Gingival Inflammation Around Single Implants
This study aims to evaluate the effect of water floss in reversing peri- implant mucositis around dental implants
- Trial name
- NCT07364916
- Testing
- Water flosser, Tooth brush and string floss
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Plaque Induced Gingivitis
Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser
The objective of the present randomized controlled trial is to evaluate the safety and efficacy of the use of Bixdo A30 Pro Ultra Compact Water Flosser (also referred to as the "Bixdo A30 Portable Water Flosser Travel Set") in…
- Trial name
- NCT06352645
- Testing
- Bixdo Ultra Compact Water Flosser, Manual toothbrush
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Tufts University
Periodontal Diseases, Periodontitis
Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions
In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06961409
- Testing
- Saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Gingivitis, Dental Plaque Accumulation
6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health
The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health.
- Trial name
- NCT07414173
- Testing
- Test Mouthrinse, Control Mouthrinse
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive