Clinical trials: Gingival Diseases
Gingivitis
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
- Trial name
- NCT06507280
- Testing
- Periodontal theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Soft Tissue Infections, Gingival Recession
Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor Sites
Free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complication .
- Trial name
- RCT (NCT05814003)
- Testing
- hydroxylate flavones solid dispersion application
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mouth Diseases
Optical Sensor for Photodynamic Detection of Oral Pathology
Overall objective of this work is to develop better ways of detecting, diagnosing and measuring oral diseases and structures using light and optical approaches.
- Trial name
- NCT00540774
- Testing
- detection of oral pathology
- Where
- United States
- Volunteers
- 1,004 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Periodontal Diseases, Gingivitis
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases
The present study aimed to assess the effect of non-surgical periodontal treatment on serum and salivary IL-1beta, IL-18, NLRP3, ASC and Caspase-1 levels in gingivitis and Stage III Grade C periodontitis.
- Conditions
- Periodontal Diseases, Gingivitis, Periodontitis
- Trial name
- NCT06075680
- Testing
- Non-Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Marmara University
Pain, Postoperative, Gingival Diseases
Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery
When harvesting autogenous free grafts to treat periodontal conditions (e.g., lack of attached keratinized tissue, ridge defects, and other mucogingival deformities), the hard palate is the preferred donor site.
- Trial name
- NCT04957342
- Testing
- amnion-chorion membrane, Sutures
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Gingival Inflammation
Toothbrush Wear and Its Effect on Subgingival Inflammation Using Two Different Brushing Techniques
Toothbrush plaque removal, along with interproximal flossing, helps to maintain the oral cavity free from periodontal diseases and dental caries.
- Trial name
- NCT03158350
- Testing
- Instructed Brushing Method
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tufts University
Chronic Periodontitis, Aggressive Periodontitis
Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis
The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses.
- Conditions
- Chronic Periodontitis, Aggressive Periodontitis, Presence / Absence of EBV
- Trial name
- NCT01246596
- Testing
- dental root planing
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gingivitis, Plaque
A Twelve Week Study of Experimental Mouth Rinses
The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a hydroalcohol control mouth rinse and a positive control mouth rinse for the reduction of gingivitis and…
- Trial name
- NCT05120141
- Testing
- Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Ref Toothbrush, Prototype 1 Mouth Rinse
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Gingival Recession, Gingival Recession, Localized
Free Gingival Graft Versus Connective Tissue Graft
This study wil compare FGG and CTG for recession coverage in the anterior mandibula.
- Trial name
- NCT05563428
- Testing
- Free gingival graft, Connective tissue graft
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Chronic Periodontitis
Methodological Evaluation of Gingival Crevicular Fluid Volume and Elastase Level
The mechanisms underlying the formation and composition of gingival crevicular fluid (GCF) and its flow into and from periodontal pockets are not understood very well.
- Trial name
- NCT02676362
- Testing
- Gingival crevicular fluid collection with filter paper
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baskent University
Gingival Recession
Biofunctionalization of a Volume-stable Collagen Matrix (VCMX) for the Treatment of Single Gingival Recession
The treatment of single gingival recessions comprises different well-established techniques, and the association between coronally advanced flap (CAF) and the subepithelial connective tissue graft is considered the gold standard.
- Trial name
- NCT05916742
- Testing
- CAF, i-PRF, VCMX
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Juvenile Idiopathic Arthritis, Gingivitis
Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis
Aimed to be done in the planned thesis to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively…
- Conditions
- Juvenile Idiopathic Arthritis, Gingivitis, Decay, Dental
- Trial name
- NCT05217277
- Testing
- Humans ELISA kits
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periimplantitis, Periodontitis
Evaluation of the Effects of Routine Phase I Periodontal Therapy on Clinical Parameters and Levels of Gremlin-1, CTHRC1, and Tenascin-C in Gingival Crevicular Fluid and Peri-Implant Sulcular Fluid in Individuals With Periodontitis and Peri-Implantitis
The aim of this study is to compare the mechanisms of tissue destruction between natural teeth with periodontitis and implants with peri-implantitis within the same individual, and to evaluate the effects of routine Phase I…
- Trial name
- NCT07797127
- Testing
- Routine Phase I Non-Surgical Periodontal Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Plaque, Dental
Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and Saliva
This 4-week clinical study was designed to examine the antibacterial efficacy of brushing with a 0.454% stannous fluoride toothpaste with potassium nitrate and pyrophosphate compared to a toothpaste containing 0.76% MFP (marketed…
- Trial name
- NCT06353165
- Testing
- Stannous fluoride toothpaste, Colgate Dental Cream
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Recession
Effect of Connective Tissue Graft Position
Aim: The aim of this study was to compare the root coverage and aesthetic results of CAF+ CTG positioned apical to the CEJ (CAF+CTG-ACEJ) with CAF+CTG positioned on the CEJ (CAF+CTG-CEJ) for treating isolated gingival recession…
- Trial name
- NCT04181892
- Testing
- Coronally advanced flap + connective tissue graft
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Dental Plaque
Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children
The objective of this single-use, examiner blinded, randomized, two-period, cross-over, IRB-approved clinical study is to evaluate the safety and plaque removal efficacy of AutoBrush®, a new children's 360° sonic toothbrush…
- Trial name
- NCT06300073
- Testing
- Experimental: U-shaped Power Toothbrush
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Lander Enterprises, LLC
Dental Plaque
Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals
The purpose of the study is to assess the effect of enzyme containing lozenges on dental plaque accumulation in healthy adults.
- Trial name
- NCT05082103
- Testing
- Enzyme lozenge 1, Enzyme lozenge 2
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Mouth Diseases, Periodontal Inflammation
Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Diseases
The aim of this study is; detection of interleukin(IL)-38, IL-36 gamma(γ) , IL-17 and matrix metalloproteinase(MMP)-9 levels in gingival crevicular fluid (GCF), saliva and serum samples of periodontally healthy, gingivitis and…
- Conditions
- Mouth Diseases, Periodontal Inflammation, Periodontal Diseases
- Trial name
- NCT05435131
- Testing
- GCF obtaining, Saliva Obtaining, Serum obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontal Pocket
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
One of the most important elements suggested to be provided through membrane perforations to augment regeneration are cell released growth factors from the overlying periosteal and gingival cells.
- Trial name
- MPM (NCT01860495)
- Testing
- perforated membrane, G2
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
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