Clinical trials: Germ Cell Neoplasm
Neuroendocrine Tumor, Carcinoid
RegisterNET - A Registry for Neuroendocrine Tumors in the USA and Worldwide
Neuroendocrine tumors are derived from the neuroendocrine system of the gastroenteropancreatic and bronchopulmonary tract systems.
- Conditions
- Neuroendocrine Tumor, Carcinoid, Neuroendocrine Carcinoma
- Trial name
- RegisterNET (NCT02270567)
- Testing
- NETest
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Wren Laboratories LLC
Lung Cancer, Neuroendocrine Neoplasm
Dual SSTR2 and Integrin αvβ3 Targeting PET/CT Imaging
This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluate the efficacy of 68Ga-NOTA-3PTATE-RGD in lung cancer patients and neuroendocrine neoplam…
- Trial name
- NCT02817945
- Testing
- 68Ga-NOTA-3P-TATE-RGD
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Epilepsy, Glioma
Blood Brain Barrier Dysfunction in Glioma and Epileptogenesis
Gliomas are the most common and deadliest primary brain tumours in children and adults. Many people with glioma also develop epilepsy, which can be difficult to treat.
- Trial name
- Bridge (NCT07909460)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University College, London
Lung Cancer, Oral Cancer
Exploratory Study of Inhaled Afatinib Dimaleate PK Profile
This is a pilot Phase I open-label randomized single-dose two-period crossover study (in the EDDIS project) evaluating the bioequivalence, pharmacokinetics (PK), safety, and tolerability of inhaled afatinib dimaleate compared…
- Conditions
- Lung Cancer, Oral Cancer, Melanoma
- Trial name
- EDDIS-a1 (NCT06897735)
- Testing
- Afatinib Dimaleat, inhalation of afatinib dimaleate
- Where
- New Zealand
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Petrov, Andrey
Melanoma
Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor
This clinical trial tests the feasibility of patient reported outcomes monitoring with early, rapid immunotherapy toxicity subspecialty care to improve side effect management for patients with melanoma receiving an immune…
- Trial name
- NCT07660666
- Testing
- Electronic Health Record Review, Internet-Based Intervention, Patient Navigation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Melanoma, Adolescents
Sun Protection and Tanning Awareness in Rural Schools
Drawing from prior school-based skin cancer prevention programs, we have adapted intervention materials to target rural high schoolers.
- Trial name
- STARS (NCT06694571)
- Testing
- Skin cancer prevention educational presentation and activities
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Utah
Glioma
Using the Epitranscriptome to Diagnose and Treat Gliomas
Diffuse gliomas are among the most common tumors of the central nervous system, with high morbidity and mortality and very limited therapeutic possibilities.
- Trial name
- EPIGLIO (NCT06575452)
- Testing
- Blood, urine and tumoral tissue samples, Tumoral tissue samples
- Where
- 2 sites in France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Compliance, Patient, Glioblastoma
Coaching for Coping in Glioblastoma Patients and Caregivers and Its Association With Compliance to TTFields
The aim is to improve patients' compliance to TTFields therapy by a psychological video intervention in a multi-center, randomized controlled trial.
- Conditions
- Compliance, Patient, Glioblastoma, Astrocytoma, Grade IV
- Trial name
- COCOON (NCT06017063)
- Testing
- Psychological intervention
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Glioblastoma, Cytokine-Induced Killer Cells
Optimizing Cytokine-Induced Killer Cells in Glioblastoma Patients
The goal of this prospective observational cohort study is to assess the optimal in vitro production protocol for generating Cytokine-Induced Killer (CIK) cells, a type of T lymphocyte, and to evaluate the potential adverse…
- Trial name
- KillGlio (NCT06684899)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Neuroendocrine Tumors
Al18F-NOTA-octreotide PET Imaging of the Somatostatin Receptor in Neuroendocrine Tumors
The aim of this study is to evaluate the potential of Al18F-1,4,7-triazacyclononane-1,4,7-triacetate-octreotide (Al18F-NOTA-octreotide) as a positron emission tomography (PET) somatostatin receptor imaging agent in patients with…
- Trial name
- NCT03883776
- Testing
- Al18F-NOTA-octreotide, PET/CT, Venous blood samples
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Melanoma (Skin)
Metabolomic and Inflammatory Effects of Oral Aspirin (ASA) in Subjects at Risk for Melanoma
This is an open label phase II pilot study assessing the metabolomic and inflammatory effects of oral aspirin (ASA) in human subjects at risk for melanoma.
- Trial name
- NCT04062032
- Testing
- Aspirin 81 mg, Aspirin 325mg
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Utah
Melanoma (Skin Cancer)
Promoting Early Detection of Melanoma During the Mammography Experience
The proposed study is a pilot and feasibility study designed to develop materials to enhance early detection of melanomas among women at risk to develop melanoma due to indoor tanning, having a family history of melanoma or a…
- Trial name
- NCT03057327
- Testing
- Improve awareness of checking moles, Comparator
- Where
- United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Glioma
Assessing Brain Metabolism Using MRS With Deuterated Glucose
This study will investigate the use of Hydrogen 1 (1H) magnetic resonance spectroscopy (MRS) with deuterated glucose (2H-glucose) to detect dynamic glucose uptake in the brain.
- Trial name
- NCT06594315
- Testing
- Deuterated Glucose, Magnetic Resonance Imaging (MRI), Blood Sample
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Melanoma
War on Melanoma™ Public Health & Education Campaign
This trial studies how well a health educational campaign works in increasing early detection of melanoma in Oregon. The health educational campaign may provide information to help people learn about the early signs of melanoma.
- Trial name
- NCT04611568
- Testing
- Educational Intervention, Health Education, Media Campaign
- Where
- United States
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Glioma
Glioma Patients Registry Based on Radiological, Histopathological and Genetic Analysis
This prospective study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic sequencing data.
- Trial name
- NCT04220424
- Testing
- MR and Histopathology images based prediction of molecular pathology and patient survival
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Healthy Volunteer, Prostate Cancer
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes.
- Conditions
- Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer
- Trial name
- NCT04354064
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Melanoma
Neoadjuvant T-VEC in High Risk Early Melanoma
Despite the recent notable advances in the treatment of advanced melanoma with application of growing immunotherapies, patterns of response and factors resulting in treatment failure are poorly understood.
- Trial name
- NCT04427306
- Testing
- T-Vec
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pigmented Skin Lesion, Melanoma
fPAM for the in Vivo Depth Measurement of Pigmented Lesions and Melanoma Depth
The investigators propose the use of functional photoacoustic microscopy (fPAM) to evaluate both benign and malignant pigmented lesions for tumor depth.
- Trial name
- NCT02613325
- Testing
- Functional photoacoustic microscopy, Standard of care surgical excision, Single cell photoacoustic microscopy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Melanoma
Melanoma Risk-Reduction Among Patients and Family Members
Primary Objectives: To conduct semi-structured interviews with melanoma patients and family members to collect descriptive information on their UVR exposure, UVR exposure-reduction practices, melanoma early detection practices…
- Trial name
- NCT00510302
- Testing
- Questionnaire, Interview
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Diffuse Intrinsic Pontine Glioma
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine gliomas (DIPGs), which diffusely occupy the pons of brainstem, are the deadliest primary brain cancer in children.
- Trial name
- ENACTING (NCT04749641)
- Testing
- Histone H3.3-K27M Neoantigen Vaccine Therapy
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yang Zhang