Clinical trials: Geriatric Patients
Locally Advanced Esophageal Squamous Cell Carcinoma
Consolidation of Toripalimab After Chemoradiotherapy in Elderly Esophageal Cancer (EC-CRT-007)
Although definitive chemoradiotherapy (CRT) is the standard treatment option for unresectable locally advanced esophageal cancer, elderly patients tolerate intravenous concurrent CRT less well with age and comorbidities.
- Trial name
- EC-CRT-007 (NCT06187597)
- Testing
- S-1, Toripalimab, Intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sun Yat-sen University
Postoperative Pulmonary Complications, Positive End-expiratory Pressure
Individualized PEEP Titration on Postoperative Pulmonary Complications
This study aims to investigate the effectiveness and safety of implementing a personalized positive end-expiratory pressure (PEEP) management strategy guided by esophageal pressure (Pes), as well as its potential to reduce the…
- Conditions
- Postoperative Pulmonary Complications, Positive End-expiratory Pressure, Elderly, Laparoscopic Surgery
- Trial name
- NCT06150079
- Testing
- Pes-Guided PEEP titration
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Zhongshan Hospital
Humeral Fractures
Reverse Or Nothing For Complex Proximal Humeral Fractures
Reverse shoulder prosthesis has recently emerged as an acute treatment for complex proximal humeral fractures. Promising functional results have been reported in observational papers.
- Trial name
- NCT03610113
- Testing
- Reverse shoulder arthroplasty
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Consorci Sanitari de l'Anoia
Obesity, Arthritis
Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement
You are invited to participate in a research study assessing your mental status in the first days after your surgery and how you will be doing in the 2 years following the surgery.
- Trial name
- NCT01270620
- Testing
- propofol, Desflurane
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pedro Paulo Tanaka
Cognitive Impairments
Effectiveness of a Program Based on Observation-action Training (AOT) in Patients With Cognitive Impairment.
The objective of this study is to assess motor and social interaction changes after AOT intervention in patients with mild cognitive impairment and Moderate cognitive impairment.
- Trial name
- NCT05585424
- Testing
- AOT intervention
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad Europea de Madrid
Cardiac Surgery, Dexmedetomidine
Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery
A retrospective study showed that intraoperative dexmedetomidine administration was associated with decreased risk of 1-year mortality after cardiac surgery.
- Conditions
- Cardiac Surgery, Dexmedetomidine, Long-term Outcome, Mortality
- Trial name
- NCT03289325
- Testing
- dexmedetomidine hydrochloride for injection, 0.9% sodium chloride for injection
- Where
- 2 sites in China
- Volunteers
- 285 people
- Sponsor
- Peking University First Hospital
Psoriasis
A 36-Week Extension to Protocol ISA04-03
The purpose of this study is to determine the safety and efficacy of voclosporin in patients with plaque psoriasis.
- Trial name
- SPIRIT (NCT00258713)
- Testing
- voclosporin
- Where
- 29 sites in Canada
- Volunteers
- 309 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Covid19, Immuno-Deficiency
Preemptive Use of Convalescent Plasma for High-risk Patients With COVID-19
Convalescent plasma therapy has been recognized as safe and plasma transfusion is routinely used in clinical practice. A recent study showed that early administration of convalescent plasma can decrease the risk of complications…
- Conditions
- Covid19, Immuno-Deficiency, Old Age; Debility
- Trial name
- NCT04836260
- Testing
- SARS-CoV-2 convalescent plasma
- Where
- 4 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Heart Valve Diseases, Moderate to Severe Valve Disease in the Elderly
China Elderly Valve Disease Study III (China-DVD3 Study)
This study aims to conduct a second round of multicenter, prospective registry research targeting elderly patients with valvular heart disease, to understand the current status of interventions for patients with valvular heart…
- Trial name
- NCT07816146
- Where
- China
- Volunteers
- 6,612 people
- Sponsor
- Yongjian Wu, MD, PhD
Frail Elderly, Physical Activity
Effectiveness of an Intervention in Multicomponent Exercise in Patients Over 70 Years in Primary Care
Objective: To evaluate the effect of a multicomponent physical activity program, compared with the usual medical practice, to reverse prefrailty by Fried in people over 70 years, one year after the end of the intervention.
- Trial name
- MEFAP (NCT03568084)
- Testing
- MEFAP, control usual practice
- Where
- Spain
- Volunteers
- 206 people
- Sponsor
- Gerencia de Atención Primaria, Madrid
Virtual Reality, Depression
Use of Virtual Reality as a Tool for Cognitive Remediation in Elderly Depressed Patients
Depression, the most common mental disorder affecting the elderly, represents a major public health issue. This pathology leads to a loss of activity and autonomy in the elderly.
- Trial name
- REVIVED (NCT07119008)
- Testing
- Virtual reality
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Sarcopenia
Calf Circumference Versus X-ray Absorptiometry in the Diagnosis of Sarcopenia in Elderly Hospitalized Patients
This is a prospective single-center study to evaluate a diagnostic method. The main objective of the study is to evaluate the performance of calf circumference as a diagnostic method for sarcopenia in hospitalized elderly people…
- Trial name
- PAPY-SARCM (NCT05869487)
- Testing
- Dual-energy X-ray absorptiometry
- Where
- France
- Volunteers
- 298 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Fragile X Syndrome
Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)
The aim of this study is to characterize the pharmacokinetics and safety/tolerability of AFQ056 in children with Fragile X Syndrome(FXS)
- Trial name
- NCT01482143
- Testing
- AFQ056
- Where
- 4 sites in United States, Spain
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Sickle Cell Disease, Sickle Cell Anemia
A Low-Interventional Study of an Electronic Sickle Cell Disease Patient Reported Outcomes in Sickle Cell Participants
The purpose of this study is to learn more about painful crisis in people with Sickle Cell Disease. For this reason, Pfizer is conducting a study to understand how people with Sickle Cell Disease feel on a daily basis, treat…
- Trial name
- NCT06503458
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Sanguine Biosciences
Aging, Breast Cancer
The Value of Geriatric Assessments in Older Patients With Breast Cancer
Elderly cancer patients are a special group, often complicated by a variety of chronic diseases, which bring serious obstacles to surgery and adjuvant treatment.
- Conditions
- Aging, Breast Cancer, Chemotherapeutic Toxicity, Survival
- Trial name
- NCT03640117
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Comprehensive Nutritional Geriatric Assessments in Identifying Malnutrition in Older Cancer Participants
This trial studies how well comprehensive nutritional geriatric assessments work in identifying malnutrition in older cancer participants.
- Trial name
- NCT03035604
- Testing
- Comprehensive Geriatric Assessment
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Frail Elderly, Elderly
Geriatric Education and Its Effect on Certain Aspects of Hospital Care of the Nursing Home Patients - 12 Month Retrospective Study
Nursing home patients admitted to the hospital poses significant challenge for health care providers. Geriatric teaching pays particular attention to these admissions and related problems.
- Conditions
- Frail Elderly, Elderly, Hospitalization, Geriatrics
- Trial name
- NCT01213225
- Volunteers
- 20 people
- Sponsor
- Maimonides Medical Center
Elderly Patients
Citrulline, Exercise Training and Muscle Strength in the Elderly
The aim of this study is to assess the effect of citrulline supplementation on muscle strength in elderly institutionalized subjects undergoing a resistance exercise training program.
- Trial name
- CITREX (NCT01599676)
- Testing
- Citrulline, Non essential amino acid
- Where
- France
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus
SGS: a Structured Treatment and Teaching Programme for Elderly Patients With Diabetes Mellitus
It was the aim of the study to develop and evaluate the effectiveness of a new structured teaching and training programme for elderly patients with diabetes mellitus (SGS) and insulin therapy.
- Trial name
- NCT00391040
- Testing
- SGS education
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- German Diabetes Association