Clinical trials: Geriatric Disorder
Cataract
Patient Participation in Free Cataract Surgery
Age-related cataracts remain the leading cause of treatable blindness in China. The prevalence of cataract blindness continues to climb due to the expanding elderly subpopulation.
- Trial name
- NCT02633865
- Where
- China
- Volunteers
- 883 people
- Sponsor
- Sun Yat-sen University
Urinary Incontinence
Managing Urinary Incontinence in Elderly Village Women in Rural Bangladesh
An intervention consisting of group and home based exercise will be used over 6 months to assess whether this is helpful in managing urinary incontinence in elderly village women in Bangladesh.
- Trial name
- NCT02453100
- Testing
- Mobility and pelvic floor exercise, Education
- Where
- Canada
- Volunteers
- 579 people
- Sponsor
- University of Alberta
Neurocognitive Disorders, Dementia
The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension.
- Conditions
- Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and Over
- Trial name
- TAHOC (NCT05845736)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Central Hospital, Nancy, France
Aging, Cognitive Decline
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and…
- Conditions
- Aging, Cognitive Decline, Older Adults, Cardiovascular
- Trial name
- FOES (NCT07000734)
- Testing
- Risk managment, Dasatinib, Quercetin (dietary supplement)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Vaccination; Infection, COVID-19
Intradermal Administration of a COVID-19 mRNA Vaccine in Elderly
Respiratory tract infections, e.g. caused by SARS-CoV-2, disproportionately affect elderly. Vaccination has shown to be the most cost-effective approach to prevent infections.
- Trial name
- HVaNa (NCT05977127)
- Testing
- Comirnaty
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cystic Fibrosis
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor
This is a Phase 3, randomized, double blind, placebo controlled, parallel group, multicenter study in people with cystic fibrosis (CF) who are homozygous for the F508del CF transmembrane conductance regulator (CFTR) gene mutation.
- Trial name
- NCT02347657
- Testing
- VX-661 Plus Ivacaftor Combination, Ivacaftor
- Where
- 74 sites in United States, Canada and 10 more
- Volunteers
- 510 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Sleep Insufficiency
A Personalized Mind-Body Intervention (MBI) for Improving Sleep Among Women Working in Healthcare
The goal of this pilot study is to determine if a personalized trial testing a Mind-Body Intervention (MBI) can produce a meaningful increase in the average daily sleep duration among women 40-60 years of age working in…
- Trial name
- NCT05789212
- Testing
- Personalized Trial ABCCBA, Personalized Trial CBAABC
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Health Services, Geriatric
Self Care for Older Persons in Singapore: An Intervention Study
The main aim of the project is to evaluate a self-care intervention program aimed at enhancing the ability of mildly disabled and healthy older persons in Singapore to manage their health.
- Trial name
- SCOPE (NCT01672177)
- Testing
- Chronic disease self-management training
- Where
- 12 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
COVID-19, Hemodiafiltration
Immune Function in Elderly Patients With Mild to Moderate COVID-19 on Hemodialysis
This randomized controlled trial will focus on the effects of early oral nutritional supplementation on immune function in elderly patients with mild to moderate COVID-19 on maintenance hemodialysis.
- Trial name
- NCT05366205
- Testing
- Oral nutritional supplement, Nutrition consultation
- Volunteers
- 112 people
- Sponsor
- Ruijin Hospital
Postoperative Delirium, Hip Fractures
Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery
Postoperative delirium (POD) is a common and serious complication in elderly patients undergoing surgical repair for hip fractures, often triggered by acute pain, surgical stress, neuroinflammation, and opioid consumption.
- Trial name
- NCT07810556
- Testing
- Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline
- Volunteers
- 130 people
- Sponsor
- Assiut University
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Multiple Myeloma
Randomized Phase II Study in Elderly Patients With Newly Diagnosed Multiple Myeloma
To compare the efficacy and safety of bortezomib, lenalidomide and dexamethasone in elderly frail patients with newly diagnosed multiple myeloma.
- Trial name
- KMM1910 (NCT04277845)
- Testing
- Bortezomib, Lenalidomide, Dexamethasone
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Samsung Medical Center
Postoperative Cognitive Dysfunction
Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor
Postoperative cognitive dysfunction(POCD). is a central nervous system complication in cancer patients with a 8.9-46.1% incidence.
- Trial name
- TEAS (NCT05482477)
- Testing
- Transcutaneous acupoint electrical stimulation
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Colorectal Cancer
A Study of Bevacizumab (Avastin) in Combination With Capecitabine (Xeloda) in Elderly Patients With Metastatic Colorectal Cancer
This 2-arm study assessed the efficacy and safety of bevacizumab (Avastin) in combination with capecitabine (Xeloda), compared with capecitabine alone, in elderly patients with metastatic colorectal cancer.
- Trial name
- NCT00484939
- Testing
- Bevacizumab, Capecitabine
- Where
- 55 sites in Austria, Canada and 10 more
- Volunteers
- 280 people
- Sponsor
- Hoffmann-La Roche
Colorectal Neoplasms
Yield and Safety of Colonoscopy in Patients Older Than 80 Years
The aim of the study is to study the risk of colorectal cancer and polyps in people older than 80 years compared to the younger age group.
- Trial name
- NCT00590434
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Midwest Biomedical Research
Coronary Arteriosclerosis, Endothelial Dysfunction
Effect of Aged Garlic Extract (AGE) on Improving Coronary Atherosclerosis in People With Type 2 Diabetes Mellitus
The purpose of this research study is to see the effect of taking Aged Garlic Extract (AGE) on the progression of coronary plaque, a condition called atherosclerosis, in people diagnosed with Diabetes.
- Conditions
- Coronary Arteriosclerosis, Endothelial Dysfunction, Type 2 Diabetes Mellitus
- Trial name
- NCT03931434
- Testing
- Aged Garlic Extract (AGE)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
COVID-19
Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19
The purpose of this pragmatic randomized trial is to evaluate the vaccine effectiveness of the COVID-19 vaccine, mRNA-1273, in adults aged 50-64 years without known risk factors for severe COVID-19 infection.
- Trial name
- DAN-COVID (NCT07279766)
- Testing
- mRNA-1273 (Moderna COVID-19 vaccine)
- Where
- 2 sites in Denmark
- Volunteers
- 41,060 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Dementia
The Effect of a Comprehensive Dementia Education Program on Improving Attitudes Toward People Living With Dementia
This randomized controlled trial focuses on Indonesian nursing students and examines the effectiveness of virtual reality (VR) dementia education programs. The study addresses the following research questions: 1.
- Trial name
- VReducationRCT (NCT07265856)
- Testing
- Comprehensive VR Program, Conventional Lecture Program (Non-VR)
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Infertility
IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial.
Prospective randomised controlled trial: 3 IUI cycles versus 1 IVF/ICSI cycle in women aged 38-42 years.
- Trial name
- NCT01992731
- Testing
- Drug: Follitropine Bèta
- Where
- Belgium
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Influenza
Study of a Pandemic Influenza Vaccine in Elderly Participants
The World Health Organisation has warned that an influenza pandemic is inevitable. The avian influenza H5N1 virus strain is one of the leading candidates to cause the next influenza pandemic.
- Trial name
- NCT00376402
- Testing
- H5N1 Pandemic Influenza Vaccine
- Where
- 2 sites in Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seqirus